KEGG   ENZYME: 1.8.4.7Help
Entry
EC 1.8.4.7                  Enzyme                                 

Name
enzyme-thiol transhydrogenase (glutathione-disulfide);
[xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase;
enzyme-thiol transhydrogenase (oxidized-glutathione);
glutathione-dependent thiol:disulfide oxidoreductase;
thiol:disulphide oxidoreductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a disulfide as acceptor
BRITE hierarchy
Sysname
[xanthine-dehydrogenase]:glutathione-disulfide S-oxidoreductase
Reaction(IUBMB)
[xanthine dehydrogenase] + glutathione disulfide = [xanthine oxidase] + 2 glutathione [RN:R04039]
Reaction(KEGG)
Substrate
[xanthine dehydrogenase] [CPD:C03544];
glutathione disulfide [CPD:C00127]
Product
[xanthine oxidase] [CPD:C02756];
glutathione [CPD:C00051]
Comment
Converts EC 1.17.1.4 xanthine dehydrogenase into EC 1.17.3.2 xanthine oxidase in the presence of glutathione disulfide; also reduces the disulfide bond of ricin. Not inhibited by Cu2+ or thiol reagents.
History
EC 1.8.4.7 created 1989, modified 2002
Pathway
Glutathione metabolism
Reference
1  [PMID:6960894]
  Authors
Battelli MG, Lorenzoni E.
  Title
Purification and properties of a new glutathione-dependent thiol:disulphide oxidoreductase from rat liver.
  Journal
Biochem. J. 207 (1982) 133-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
85030-79-1

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