KEGG   ENZYME: 1.8.7.2Help
Entry
EC 1.8.7.2                  Enzyme                                 

Name
ferredoxin:thioredoxin reductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
ferredoxin:thioredoxin disulfide oxidoreductase
Reaction(IUBMB)
2 reduced ferredoxin + thioredoxin disulfide = 2 oxidized ferredoxin + thioredoxin + 2 H+ [RN:R09502]
Reaction(KEGG)
Substrate
reduced ferredoxin [CPD:C00138];
thioredoxin disulfide [CPD:C00343]
Product
oxidized ferredoxin [CPD:C00139];
thioredoxin [CPD:C00342];
H+ [CPD:C00080]
Comment
The enzyme contains a [4Fe-4S] cluster and internal disulfide. It forms a mixed disulfide with thioredoxin on one side, and docks ferredoxin on the other side, enabling two one-electron transfers. The reduced thioredoxins generated by the enzyme activate the Calvin cycle enzymes EC 3.1.3.11 (fructose-bisphosphatase), EC 3.1.3.37
(sedoheptulose-bisphosphatase) and EC 2.7.1.19 (phosphoribulokinase) as well as other chloroplast enzymes by disulfide reduction.
History
EC 1.8.7.2 created 2010
Orthology
K17892  
ferredoxin-thioredoxin reductase catalytic chain
Genes
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
POPTR_0001s34690g(POPTRDRAFT_1068756)
VVI: 
SLY: 
SPEN: 
SOT: 
102579143(ftrbpot)
SIND: 
BVG: 
NNU: 
OSA: 
4346508(FTR-B)
DOSA: 
Os09t0249900-01(Os09g0249900)
OBR: 
BDI: 
SBI: 
SORBI_10g006650(SORBIDRAFT_10g006650)
ZMA: 
542532(ftr1)
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
APRO: 
CCP: 
CHC_1145(ftrB)
DHY: 
SYN: 
sll0554(ftrC)
SYZ: 
SYY: 
SYT: 
SYS: 
SYQ: 
SYJ: 
SYW: 
SYNW0318(ftrC)
SYC: 
syc2357_c(ftrC)
SYF: 
SYD: 
SYE: 
SYG: 
SYR: 
SYX: 
SYP: 
CYA: 
CYB: 
SYNE: 
SYNP: 
SYNK: 
SYNR: 
SYND: 
SYU: 
SYH: 
TEL: 
tll0113(ftrC)
THN: 
MAR: 
MAE_51290(ftrC)
MPK: 
CYT: 
cce_3398(ftrC)
CYP: 
CYC: 
CYN: 
CYH: 
CYJ: 
AMR: 
CGC: 
CAN: 
CSN: 
DSL: 
HAO: 
GLP: 
CMP: 
CYU: 
GEN: 
GEE: 
TER: 
LEP: 
LEN: 
LET: 
GEI: 
OAC: 
ONI: 
PSEU: 
CEP: 
MIC: 
ARP: 
ANA: 
alr4065(ftrC)
NPU: 
NOS: 
NOP: 
NON: 
AVA: 
ANB: 
ACY: 
AWA: 
NAZ: 
CSG: 
CALO: 
CALT: 
CALH: 
RIV: 
CTHE: 
PLP: 
SCS: 
FIS: 
CEO: 
ETSB_1018(ftrC)
NMV: 
NIO: 
 » show all
Taxonomy
Reference
1  [PMID:1910303]
  Authors
Buchanan BB
  Title
Regulation of CO2 assimilation in oxygenic photosynthesis: the ferredoxin/thioredoxin system. Perspective on its discovery, present status, and  future development.
  Journal
Arch. Biochem. Biophys. 288 (1991) 1-9.
Reference
2  [PMID:7628465]
  Authors
Chow LP, Iwadate H, Yano K, Kamo M, Tsugita A, Gardet-Salvi L, Stritt-Etter AL, Schurmann P
  Title
Amino acid sequence of spinach ferredoxin:thioredoxin reductase catalytic subunit and identification of thiol groups constituting a redox-active disulfide and a [4Fe-4S] cluster.
  Journal
Eur. J. Biochem. 231 (1995) 149-56.
  Sequence
Reference
3  [PMID:8784198]
  Authors
Staples CR, Ameyibor E, Fu W, Gardet-Salvi L, Stritt-Etter AL, Schurmann P, Knaff DB, Johnson MK
  Title
The function and properties of the iron-sulfur center in spinach ferredoxin: thioredoxin reductase: a new biological role for iron-sulfur clusters.
  Journal
Biochemistry. 35 (1996) 11425-34.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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