KEGG   ENZYME: 1.8.98.1Help
Entry
EC 1.8.98.1                 Enzyme                                 

Name
CoB---CoM heterodisulfide reductase;
heterodisulfide reductase;
soluble heterodisulfide reductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
coenzyme B:coenzyme M:methanophenazine oxidoreductase
Reaction(IUBMB)
coenzyme B + coenzyme M + methanophenazine = N-{7-[(2-sulfoethyl)dithio]heptanoyl}-O3-phospho-L-threonine + dihydromethanophenazine [RN:R04540]
Reaction(KEGG)
R04540;
(other) R09092
Show
Substrate
coenzyme B [CPD:C04628];
coenzyme M [CPD:C03576];
methanophenazine [CPD:C11903]
Product
N-{7-[(2-sulfoethyl)dithio]heptanoyl}-O3-phospho-L-threonine;
dihydromethanophenazine [CPD:C11904]
Comment
This enzyme is found in methanogenic archaea, particularly Methanosarcina species, and regenerates coenzyme M and coenzyme B after the action of EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase. Contains (per heterodimeric unit) two distinct b-type hemes and two [4Fe-4S] clusters [3]. Highly specific for both coenzyme M and coenzyme B. Reacts with various phenazine derivatives, including 2-hydroxyphenazine and 2-bromophenazine.
History
EC 1.8.98.1 created 2003
Pathway
Methane metabolism
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K03388  
heterodisulfide reductase subunit A
K03389  
heterodisulfide reductase subunit B
K03390  
heterodisulfide reductase subunit C
K08264  
heterodisulfide reductase subunit D
K08265  
heterodisulfide reductase subunit E
Genes
TIG: 
TVI: 
TMB: 
HHC: 
TGR: 
TKM: 
TNI: 
TVNIR_3244(hdrB_[H]) TVNIR_3245(hdlC_[H]) TVNIR_3247(hdrA_[H]) TVNIR_3248(hdlB_[H]) TVNIR_3249
TVR: 
EBS: 
APRS: 
TBN: 
SEDS: 
ENM: 
EBS_2145(hdrB)
CBX: 
SHD: 
TBD: 
SDR: 
GSU: 
GSU0090(hdrA) GSU0091(hdrB) GSU0092(hdrC)
GSK: 
KN400_0065(hdrA) KN400_0066(hdrB) KN400_0067(hdrC)
GME: 
Gmet_2084(bamE) Gmet_3424(hdrC) Gmet_3425(hdrB) Gmet_3426(hdrA)
GUR: 
GLO: 
GBM: 
Gbem_0030(hdrA) Gbem_0031(hdrB) Gbem_0032(hdrC) Gbem_1447(bamE)
GEO: 
Geob_0215(bamE-1) Geob_0231(bamE-2) Geob_3723(hdrA) Geob_3724(hdrB) Geob_3725(hdrC)
GEM: 
GEB: 
GPI: 
GAO: 
DVU: 
DVU2402(hdrA) DVU2403(hdrB) DVU2404(hdrC)
DVL: 
DVM: 
DVG: 
DDE: 
DDS: 
DDN: 
DMA: 
DSA: 
DAS: 
DAF: 
DHY: 
DPI: 
DGG: 
DGI_1048(hdrC) DGI_1049(hdrB) DGI_1050(hdrA)
DFI: 
DEJ: 
DBA: 
DOA: 
DRT: 
DPS: 
DAK: 
DPR: 
DSF: 
DOL: 
DAL: 
DAT: 
HRM2_11710(hdrA1) HRM2_11850(hdrA2) HRM2_22720(hdrL2) HRM2_22750(hdrA4) HRM2_22760(hdrD2) HRM2_22770(hdrD2')
DTO: 
ADE: 
ACP: 
AFW: 
ANK: 
SAT: 
DAO: 
DTI: 
SFU: 
DBR: 
HDN: 
AEP: 
AFE: 
AFR: 
ACU: 
ACZ: 
AFI: 
BTS: 
RCH: 
RUM: 
BYL: 
SWO: 
SLP: 
DMT: 
DRM: 
DAE: 
DCA: 
DKU: 
DRU: 
DGI: 
PTH: 
PTH_1410(HdrA) PTH_1412(HdrB) PTH_1413(GlpC)
DAU: 
TJR: 
SGY: 
DOR: 
DAI: 
DMI: 
HMO: 
SAY: 
SAP: 
CHY: 
MTA: 
ADG: 
TPZ: 
TNR: 
MAS: 
NTH: 
AFO: 
SHI: 
CAN: 
CYC: 
OAC: 
NOP: 
DLY: 
DEW: 
TRO: 
OTE: 
TSU: 
TBE: 
IPO: 
BOA: 
BCEL: 
BACC: 
OSP: 
APS: 
AFD: 
ASH: 
CTE: 
CT1245 CT1246(hdrA-2)
CPC: 
CLZ: 
CCH: 
CPH: 
CLI: 
PVI: 
PLT: 
PPH: 
CTS: 
AAE: 
aq_391 aq_395(hdrA) aq_398(hdrC) aq_400(hdrB)
HYA: 
HHO: 
HYS: 
HTH: 
HTH_1878(hdrB1) HTH_1879(hdrC1) HTH_1881(hdrA) HTH_1882(hdrB2) HTH_1883(hdrC2)
HTE: 
TAL: 
TRD: 
TTK: 
DTE: 
TYE: 
TID: 
TCM: 
CTHI: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMP0825(hdrA) MMP1053(hdrB2) MMP1054(hdrC2) MMP1154(hdrC1) MMP1155(hdrB1) MMP1697(hdrA)
MMQ: 
MMX: 
MMZ: 
MMD: 
MMAK: 
MMAO: 
MAE: 
MVN: 
MVO: 
MOK: 
MAC: 
MA_0687(hdrE) MA_0688(hdrD) MA_2868(hdrA) MA_3126(hdrB) MA_3127(hdrC) MA_3128(hdrA) MA_4236(hdrC) MA_4237(hdrB)
MBA: 
MBY: 
MBW: 
MBAR: 
MBAK: 
MMA: 
MMAZ: 
MMJ: 
MVC: 
MEK: 
MLS: 
METM: 
MEF: 
MEQ: 
MSJ: 
MSZ: 
MSW: 
MTHE: 
MTHR: 
MHOR: 
MBU: 
MMET: 
MMH: 
MEV: 
MZH: 
MPY: 
MHZ: 
MTP: 
MCJ: 
MCON_3279(hdrA) MCON_3282(hdrC) MCON_3283(hdrB) MCON_3441(hdrE) MCON_3442(hdrD)
MHI: 
MHU: 
MLA: 
MEM: 
MBG: 
BN140_0752(hdrA1) BN140_1726(hdrC) BN140_1727(hdrB) BN140_1728(hdrA3)
MEMA: 
MMAB1_0971(hdrA) MMAB1_2221(hdrC) MMAB1_2222(hdrB) MMAB1_2223(hdrA)
MPI: 
MBN: 
MFO: 
MPL: 
MPD: 
MCP_1576(hdrA-1) MCP_1577(hdrB-1) MCP_1578(hdrC-1) MCP_1989(hdrA_mvhD) MCP_1990(hdrB-2) MCP_1991(hdrC-2) MCP_2768(hdrA-2) MCP_2769(hdrB-3) MCP_2770(hdrC-3)
MEZ: 
Mtc_1469(hdrC-1) Mtc_1470(hdrB-1) Mtc_1471(hdrA1) Mtc_2473(hdrA-2) Mtc_2474(hdrB-2) Mtc_2475(hdrC-2)
RCI: 
LRC437(hdrA-1) LRC438(hdrB-1) LRC439(hdrC-1) RCIX594(hdrC-2) RCIX595(hdrB-2) RCIX596(hdrA-2) RRC256(hdrC-3) RRC257(hdrB-3) RRC258(hdrA-3)
MTH: 
MMG: 
METC: 
MST: 
Msp_0125(hdrC2) Msp_0126(hdrB2) Msp_0127(hdrA2) Msp_1013(hdrB1) Msp_1014(hdrC1) Msp_1476(hdrA1)
MSI: 
MRU: 
mru_0117(hdrA) mru_0816(hdrC) mru_0817(hdrB1)
MEB: 
Abm4_0693(hdrC1) Abm4_0694(hdrB1) Abm4_0695(hdrA1) Abm4_1308(hdrB2) Abm4_1309(hdrC2) Abm4_1691(hdrA2)
MMIL: 
sm9_0982(hdrC1) sm9_0983(hdrB1) sm9_0984(hdrA1) sm9_1716(hdrB3) sm9_1717(hdrC2) sm9_2251(hdrA2)
MEYE: 
MOL: 
MEL: 
MEW: 
METH: 
MFC: 
BRM9_0490(hdrB1) BRM9_0491(hdrC1) BRM9_1362(hdrC2) BRM9_1363(hdrB3) BRM9_1364(hdrA1) BRM9_2298(hdrA2)
MFI: 
MCUB: 
MCBB_1055(hdrC1) MCBB_1056(hdrB1) MCBB_1057(hdrA1) MCBB_1489(hdrB3) MCBB_1490(hdrC3) MCBB_2243(hdrA3)
MFV: 
MKA: 
MK0249(hdrA_1) MK0265(hdrA_2) MK0572(hdrB) MK0573(hdrC)
AFU: 
AFG: 
APO: 
AVE: 
AST: 
FPL: 
GAC: 
GAH: 
NGE: 
TAR: 
MAX: 
MER: 
MEAR: 
Mpt1_c02960(hdrC1) Mpt1_c02970(hdrB1) Mpt1_c08830(hdrB2) Mpt1_c08840(hdrC2) Mpt1_c10580(hdrA)
MARC: 
ABI: 
ACF: 
PFM: 
SSO: 
SSO1127(hdrC-1) SSO1129(hdrB-1) SSO1131(hdrA) SSO1134(hdrC-2) SSO1135(hdrB-2)
SOL: 
SSOA: 
SSOL: 
SSOF: 
STO: 
SAI: 
SACN: 
SACR: 
SACS: 
SIS: 
SIA: 
SIM: 
SID: 
SIY: 
SIN: 
SII: 
SIH: 
SIR: 
SIC: 
SULA: 
MSE: 
MCN: 
AHO: 
VDI: 
VMO: 
KCR: 
LOKI: 
BARC: 
AOA65_0029(hdrB_1) AOA65_0030(hdrC_1) AOA65_1112(hdrA_1) AOA65_1193(hdrA_2) AOA65_1400(hdrC_2) AOA65_1401(hdrB_2) AOA65_1402(hdrA_3) AOA65_1719(hdlA_2) AOA65_1887(hdrB_3) AOA65_1888(hdrC_3) AOA65_1993(hdrB_4) AOA65_1994(hdrC_4) AOA65_1995(hdrA_4)
BARB: 
AOA66_0155(hdrA_1) AOA66_1507(hdrB_1) AOA66_1508(hdrC_1) AOA66_1510(hdrA_2) AOA66_1512(hdlA_2) AOA66_1513(hdrA_3) AOA66_1526(hdrA_4) AOA66_1731(hdrB_2) AOA66_1732(hdrC_2)
 » show all
Taxonomy
Reference
1  [PMID:2121478]
  Authors
Hedderich R, Berkessel A, Thauer RK.
  Title
Purification and properties of heterodisulfide reductase from Methanobacterium thermoautotrophicum (strain Marburg).
  Journal
Eur. J. Biochem. 193 (1990) 255-61.
  Sequence
Reference
2  [PMID:9555882]
  Authors
Abken HJ, Tietze M, Brodersen J, Baumer S, Beifuss U, Deppenmeier U.
  Title
Isolation and characterization of methanophenazine and function of phenazines in membrane-bound electron transport of Methanosarcina mazei Go1.
  Journal
J. Bacteriol. 180 (1998) 2027-32.
Reference
3  [PMID:9665708]
  Authors
Simianu M, Murakami E, Brewer JM, Ragsdale SW.
  Title
Purification and properties of the heme- and iron-sulfur-containing heterodisulfide reductase from Methanosarcina thermophila.
  Journal
Biochemistry. 37 (1998) 10027-39.
Reference
4  [PMID:11034998]
  Authors
Murakami E, Deppenmeier U, Ragsdale SW.
  Title
Characterization of the intramolecular electron transfer pathway from 2-hydroxyphenazine to the heterodisulfide reductase from Methanosarcina thermophila.
  Journal
J. Biol. Chem. 276 (2001) 2432-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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