KEGG   ENZYME: 1.97.1.11Help
Entry
EC 1.97.1.11                Enzyme                                 
Name
thyroxine 5-deiodinase;
diiodothyronine 5'-deiodinase[ambiguous];
iodothyronine 5-deiodinase;
iodothyronine inner ring monodeiodinase;
type III iodothyronine deiodinase
Class
Oxidoreductases;
Other oxidoreductases;
Sole sub-subclass for oxidoreductases that do not belong in the other subclasses
BRITE hierarchy
Sysname
acceptor:3,3',5'-triiodo-L-thyronine oxidoreductase (iodinating)
Reaction(IUBMB)
3,3',5'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2 [RN:R07230]
Reaction(KEGG)
Substrate
3,3',5'-triiodo-L-thyronine [CPD:C07639];
iodide [CPD:C00708];
A [CPD:C00028];
H+ [CPD:C00080]
Product
L-thyroxine [CPD:C01829];
AH2 [CPD:C00030]
Comment
The enzyme activity has only been demonstrated in the direction of 5-deiodination. This removal of the 5-iodine, i.e. from the inner ring, largely inactivates the hormone thyroxine.
Orthology
K07754  
thyroxine 5-deiodinase
Genes
HSA: 
1735(DIO3)
PTR: 
467559(DIO3)
PPS: 
100992412(DIO3)
GGO: 
101125055(DIO3)
PON: 
100452020(DIO3)
MCC: 
708027(DIO3)
MMU: 
107585(Dio3)
RNO: 
29475(Dio3)
CFA: 
612596(DIO3)
AML: 
FCA: 
101094186(DIO3)
BTA: 
494549(DIO3)
SSC: 
414378(DIO3)
ECB: 
100146344(DIO3)
SHR: 
100930662(DIO3)
GGA: 
395939(DIO3)
TGU: 
100232538(DIO3)
XLA: 
397779(dio3)
XTR: 
100038242(dio3)
DRE: 
798872(dio3)
TRU: 
100191069(dio3a) 100191070(dio3b)
 » show all
Taxonomy
Reference
1  [PMID:7053997]
  Authors
Chopra IJ, Chua Teco GN.
  Title
Characteristics of inner ring (3 or 5) monodeiodination of 3,5-diiodothyronine in rat liver: evidence suggesting marked similarities of inner and outer ring deiodinases for iodothyronines.
  Journal
Endocrinology. 110 (1982) 89-97.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:11898402]
  Authors
Kohrle J.
  Title
Iodothyronine deiodinases.
  Journal
Methods. Enzymol. 347 (2002) 125-67.
  Organism
Rattus norvegicus [GN:rno], Homo sapiens [GN:hsa], Mus musculus [GN:mmu]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
74506-30-2
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