KEGG   ENZYME: 1.97.1.11Help
Entry
EC 1.97.1.11                Enzyme                                 

Name
thyroxine 5-deiodinase;
diiodothyronine 5'-deiodinase[ambiguous];
iodothyronine 5-deiodinase;
iodothyronine inner ring monodeiodinase;
type III iodothyronine deiodinase
Class
Oxidoreductases;
Other oxidoreductases;
Sole sub-subclass for oxidoreductases that do not belong in the other subclasses
BRITE hierarchy
Sysname
acceptor:3,3',5'-triiodo-L-thyronine oxidoreductase (iodinating)
Reaction(IUBMB)
3,3',5'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2 [RN:R07230]
Reaction(KEGG)
Substrate
3,3',5'-triiodo-L-thyronine [CPD:C07639];
iodide [CPD:C00708];
A [CPD:C00028];
H+ [CPD:C00080]
Product
L-thyroxine [CPD:C01829];
AH2 [CPD:C00030]
Comment
The enzyme activity has only been demonstrated in the direction of 5-deiodination. This removal of the 5-iodine, i.e. from the inner ring, largely inactivates the hormone thyroxine.
History
EC 1.97.1.11 created 2003
Orthology
K07754  
thyroxine 5-deiodinase
Genes
HSA: 
1735(DIO3)
PTR: 
467559(DIO3)
PPS: 
100992412(DIO3)
GGO: 
101125055(DIO3)
PON: 
100452020(DIO3)
NLE: 
100592037(DIO3)
MCC: 
708027(DIO3)
MCF: 
102126318(DIO3)
CJC: 
100411094(DIO3)
MMU: 
107585(Dio3)
RNO: 
29475(Dio3)
CGE: 
100753739(Dio3)
HGL: 
101697914(Dio3)
TUP: 
102489833(DIO3)
CFA: 
612596(DIO3)
AML: 
UMR: 
103656768(DIO3)
FCA: 
101094186(DIO3)
PTG: 
102968143(DIO3)
BTA: 
494549(DIO3)
PHD: 
102332556(DIO3)
CHX: 
102180706(DIO3)
OAS: 
100142657(DIO3)
SSC: 
414378(DIO3)
CFR: 
102516992(DIO3)
BACU: 
103007374(DIO3)
LVE: 
103088549(DIO3)
ECB: 
100146344(DIO3)
MYB: 
102240362(DIO3)
MYD: 
102764457(DIO3)
PALE: 
102884557(DIO3)
MDO: 
100022264(DIO3)
SHR: 
100930662(DIO3)
GGA: 
395939(DIO3)
APLA: 
101801522(DIO3)
TGU: 
100232538(DIO3)
FAB: 
101819627(DIO3)
PHI: 
102113106(DIO3)
FPG: 
101916216(DIO3)
FCH: 
102055253(DIO3)
CLV: 
102085218(DIO3)
ASN: 
PSS: 
102445065(DIO3)
CMY: 
102944395(DIO3)
ACS: 
103279636(dio3)
XLA: 
397779(dio3)
XTR: 
100038242(dio3)
DRE: 
100538339(dio3a) 798872(dio3b)
TRU: 
100191069(dio3a) 100191070(dio3b)
LCM: 
102353393(DIO3)
CMK: 
103175341(dio3)
BFO: 
LGI: 
 » show all
Taxonomy
Reference
1  [PMID:7053997]
  Authors
Chopra IJ, Chua Teco GN.
  Title
Characteristics of inner ring (3 or 5) monodeiodination of 3,5-diiodothyronine in rat liver: evidence suggesting marked similarities of inner and outer ring deiodinases for iodothyronines.
  Journal
Endocrinology. 110 (1982) 89-97.
Reference
2  [PMID:11898402]
  Authors
Kohrle J.
  Title
Iodothyronine deiodinases.
  Journal
Methods. Enzymol. 347 (2002) 125-67.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
74506-30-2

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