KEGG   ENZYME: 2.1.1.102Help
Entry
EC 2.1.1.102                Enzyme                                 

Name
demethylmacrocin O-methyltransferase;
demethylmacrocin methyltransferase;
DMOMT
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:demethylmacrocin 2'''-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + demethylmacrocin = S-adenosyl-L-homocysteine + macrocin [RN:R02859]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
demethylmacrocin [CPD:C02400]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
macrocin [CPD:C00744]
Comment
Requires Mg2+. The enzyme, isolated from the bacterium Streptomyces fradiae, is involved in the biosynthesis of the macrolide antibiotic tylosin. The 2-hydroxy group of a 6-deoxy-D-allose moiety in demethylmacrocin acts as the methyl acceptor. Also acts on demethyllactenocin, giving lactenocin. Not identical with EC 2.1.1.101 macrocin O-methyltransferase.
History
EC 2.1.1.102 created 1992
Pathway
Biosynthesis of 12-, 14- and 16-membered macrolides
Biosynthesis of secondary metabolites
Orthology
K15995  
demethylmacrocin O-methyltransferase
Reference
1  [PMID:3170602]
  Authors
Kreuzman AJ, Turner JR, Yeh WK.
  Title
Two distinctive O-methyltransferases catalyzing penultimate and terminal reactions of macrolide antibiotic (tylosin) biosynthesis. Substrate specificity, enzyme inhibition, and kinetic mechanism.
  Journal
J. Biol. Chem. 263 (1988) 15626-33.
  Organism
Streptomyces fradiae
  Sequence
[up:Q9ZHQ4]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
120313-64-6

DBGET integrated database retrieval system