| Entry |
|
|---|
| Name |
demethylmacrocin O-methyltransferase;
demethylmacrocin methyltransferase
|
|---|
| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
 |
|---|
| Sysname |
S-adenosyl-L-methionine:demethylmacrocin 2'''-O-methyltransferase
|
|---|
| Reaction(IUBMB) |
S-adenosyl-L-methionine + demethylmacrocin = S-adenosyl-L-homocysteine + macrocin [RN: R02859]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
demethylmacrocin [CPD: C02400]
|
|---|
| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
macrocin [CPD: C00744]
|
|---|
| Comment |
The 2-hydroxy group of a 6-deoxy-D-allose residue in demethylmacrocin acts as a methyl acceptor. Not identical with EC 2.1.1.101 macrocin O-methyltransferase.
|
|---|
| Pathway |
| Biosynthesis of 12-, 14- and 16-membered macrolides | | Biosynthesis of secondary metabolites |
|
|---|
| Orthology |
| demethylmacrocin O-methyltransferase |
|
|---|
| Reference |
|
|---|
| Authors |
Kreuzman AJ, Turner JR, Yeh WK. |
|---|
| Title |
Two distinctive O-methyltransferases catalyzing penultimate and terminal reactions of macrolide antibiotic (tylosin) biosynthesis. Substrate specificity, enzyme inhibition, and kinetic mechanism. |
|---|
| Journal |
J. Biol. Chem. 263 (1988) 15626-33. |
|---|
| Organism |
Streptomyces fradiae |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 120313-64-6 |
|---|
