| Entry |
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| Name |
tryptophan 2-C-methyltransferase;
tryptophan 2-methyltransferase;
S-adenosylmethionine:tryptophan 2-methyltransferase
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
 |
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| Sysname |
S-adenosyl-L-methionine:L-tryptophan 2-C-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan [RN: R08547]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
L-tryptophan [CPD: C00078]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
L-2-methyltryptophan [CPD: C16831]
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| Comment |
D-Tryptophan and (indol-3-yl)pyruvate can also act as acceptors, but more slowly.
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| Reference |
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| Authors |
Frenzel T, Zhou P, Floss HG. |
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| Title |
Formation of 2-methyltryptophan in the biosynthesis of thiostrepton: isolation of S-adenosylmethionine:tryptophan 2-methyltransferase. |
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| Journal |
Arch. Biochem. Biophys. 278 (1990) 35-40. |
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| Organism |
Streptomyces laurentii |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 126626-83-3 |
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