KEGG   ENZYME: 2.1.1.106Help
Entry
EC 2.1.1.106                Enzyme                                 

Name
tryptophan 2-C-methyltransferase;
tryptophan 2-methyltransferase;
S-adenosylmethionine:tryptophan 2-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:L-tryptophan 2-C-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan [RN:R08547]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
L-tryptophan [CPD:C00078]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
L-2-methyltryptophan [CPD:C16831]
Comment
D-Tryptophan and (indol-3-yl)pyruvate can also act as acceptors, but more slowly.
History
EC 2.1.1.106 created 1992
Reference
1  [PMID:2321967]
  Authors
Frenzel T, Zhou P, Floss HG.
  Title
Formation of 2-methyltryptophan in the biosynthesis of thiostrepton: isolation of S-adenosylmethionine:tryptophan 2-methyltransferase.
  Journal
Arch. Biochem. Biophys. 278 (1990) 35-40.
  Organism
Streptomyces laurentii
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
126626-83-3

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