KEGG   ENZYME: 2.1.1.110Help
Entry
EC 2.1.1.110                Enzyme                                 

Name
sterigmatocystin 8-O-methyltransferase;
sterigmatocystin methyltransferase;
O-methyltransferase II;
sterigmatocystin 7-O-methyltransferase (incorrect);
S-adenosyl-L-methionine:sterigmatocystin 7-O-methyltransferase (incorrect);
OmtA
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:sterigmatocystin 8-O-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + sterigmatocystin = S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin [RN:R03111];
(2) S-adenosyl-L-methionine + dihydrosterigmatocystin = S-adenosyl-L-homocysteine + 8-O-methyldihydrosterigmatocystin [RN:R10307]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
sterigmatocystin [CPD:C00961];
dihydrosterigmatocystin [CPD:C20445]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
8-O-methylsterigmatocystin [CPD:C03686];
8-O-methyldihydrosterigmatocystin [CPD:C03944]
Comment
Dihydrosterigmatocystin can also act as acceptor. Involved in the biosynthesis of aflatoxins in fungi.
Pathway
Aflatoxin biosynthesis
Orthology
K17650  
sterigmatocystin 8-O-methyltransferase
Genes
NFI: 
AFM: 
AOR: 
AOR_1_56014(AO090026000026)
AFV: 
ACT: 
Taxonomy
Reference
1  [PMID:3111363]
  Authors
Bhatnagar D, McCormick SP, Lee LS, Hill RA.
  Title
Identification of O-methylsterigmatocystin as an aflatoxin B1 and G1 precursor in Aspergillus parasiticus.
  Journal
Appl. Environ. Microbiol. 53 (1987) 1028-33.
  Organism
Aspergillus parasiticus
Reference
2  [PMID:2802602]
  Authors
Yabe K, Ando Y, Hashimoto J, Hamasaki T.
  Title
Two distinct O-methyltransferases in aflatoxin biosynthesis.
  Journal
Appl. Environ. Microbiol. 55 (1989) 2172-7.
  Organism
Aspergillus parasiticus
Reference
3  [PMID:8285664]
  Authors
Yu J, Cary JW, Bhatnagar D, Cleveland TE, Keller NP, Chu FS.
  Title
Cloning and characterization of a cDNA from Aspergillus parasiticus encoding an O-methyltransferase involved in aflatoxin biosynthesis.
  Journal
Appl. Environ. Microbiol. 59 (1993) 3564-71.
  Organism
Aspergillus parasiticus
  Sequence
[up:Q12120]
Reference
4  [PMID:12406770]
  Authors
Lee LW, Chiou CH, Linz JE
  Title
Function of native OmtA in vivo and expression and distribution of this protein in colonies of Aspergillus parasiticus.
  Journal
Appl. Environ. Microbiol. 68 (2002) 5718-27.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
116958-29-3

DBGET integrated database retrieval system