KEGG   ENZYME: 2.1.1.113Help
Entry
EC 2.1.1.113                Enzyme                                 
Name
site-specific DNA-methyltransferase (cytosine-N4-specific);
modification methylase;
restriction-modification system;
DNA[cytosine-N4]methyltransferase;
m4C-forming MTase;
S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:DNA-cytosine N4-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N4-methylcytosine [RN:R03003]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
DNA cytosine [CPD:C00856]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
DNA N4-methylcytosine [CPD:C03110]
Comment
This is a large group of enzymes, most of which, with enzymes of similar site specificity listed as EC 3.1.21.3 (type 1 site-specific deoxyribonuclease), EC 3.1.21.4 (type II site-specific deoxyribonuclease) or EC 3.1.21.5 (type III site-specific deoxyribonuclease), form so-called 'restriction-modification systems'. A complete listing of all of these enzymes has been produced by R.J. Roberts and is available on-line at http://rebase.neb.com/rebase/rebase.html.
Orthology
K00590  
site-specific DNA-methyltransferase (cytosine-N4-specific)
Genes
XCV: 
ABM: 
BPM: 
BTE: 
AAV: 
HPY: 
HAC: 
GBE: 
SGO: 
FRA: 
LIL: 
LA_1547
ANA: 
all3632(avaIM)
AVA: 
Ava_3014 Ava_3181
CCH: 
Cag_1099
MJA: 
MJ_0985 MJ_1448 MJ_1498
RCI: 
RCIX2329(zim)
HAL: 
VNG1543G(zim)
HMA: 
rrnAC1876(zim)
SAI: 
Saci_1975
 » show all
Taxonomy
Reference
1  [PMID:2172084]
  Authors
Kessler C, Manta V.
  Title
Specificity of restriction endonucleases and DNA modification methyltransferases a review (Edition 3).
  Journal
Gene. 92 (1990) 1-248.
Reference
2  [PMID:2690010]
  Authors
Klimasauskas S, Timinskas A, Menkevicius S, Butkiene D, Butkus V, Janulaitis A.
  Title
Sequence motifs characteristic of DNA[cytosine-N4]methyltransferases: similarity to adenine and cytosine-C5 DNA-methylases.
  Journal
Nucleic. Acids. Res. 17 (1989) 9823-32.
  Organism
Citrobacter freundii, Micrococcus varians
Reference
3  [PMID:2159140]
  Authors
Roberts RJ.
  Title
Restriction enzymes and their isoschizomers.
  Journal
Nucleic. Acids. Res. 18 Suppl (1990) 2331-65.
Reference
4  [PMID:6267988]
  Authors
Yuan R.
  Title
Structure and mechanism of multifunctional restriction endonucleases.
  Journal
Annu. Rev. Biochem. 50 (1981) 285-319.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
169592-50-1
DBGET integrated database retrieval system