KEGG   ENZYME: 2.1.1.115Help
Entry
EC 2.1.1.115                Enzyme                                 

Name
(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase;
norreticuline N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline = S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline [RN:R04713]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline [CPD:C05201]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline [CPD:C05314]
Comment
Broad substrate specificity for (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinolines; including coclaurine, norcoclaurine, isococlaurine, norarmepavine, norreticuline and tetrahydropapaverine. Both R- and S-enantiomers are methylated. The enzyme participates in the pathway leading to benzylisoquinoline alkaloid synthesis in plants. The physiological substrate is likely to be coclaurine. The enzyme was earlier termed norreticuline N-methyltransferase. However, norreticuline has not been found to occur in nature and that name does not reflect the broad specificity of the enzyme for (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinolines.
History
EC 2.1.1.115 created 1999
Pathway
Isoquinoline alkaloid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K13388  
(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase
Reference
1
  Authors
Frenzel, T., Zenk, M.H.
  Title
Purification and characterization of three isoforms of S-adenosyl-L-methionine: (R,S)-tetrahydrobenzyl-isoquinoline N-methyltransferase from Berberis koetineana cell cultures.
  Journal
Phytochemistry 29 (1990) 3491-3497.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
132084-82-3

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