KEGG   ENZYME: 2.1.1.116Help
Entry
EC 2.1.1.116                Enzyme                                 

Name
3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline [RN:R03832]
Reaction(KEGG)
R03832;
(other) R05212
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Substrate
S-adenosyl-L-methionine [CPD:C00019];
3'-hydroxy-N-methyl-(S)-coclaurine [CPD:C05202]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(S)-reticuline [CPD:C02105]
Comment
Involved in isoquinoline alkaloid metabolism in plants. The enzyme has also been shown to catalyse the methylation of (RS)-laudanosoline, (S)-3'-hydroxycoclaurine and (RS)-7-O-methylnorlaudanosoline.
History
EC 2.1.1.116 created 1999
Pathway
Isoquinoline alkaloid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K13386  
3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase
Reference
1
  Authors
Frenzel, T., Zenk, M.H.
  Title
S-Adenosyl-L-methionine: 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase, a regio- and stereoselective enzyme of the (S)-reticuline pathway.
  Journal
Phytochemistry 29 (1990) 3505-3511.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
132084-81-2

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