| Entry |
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| Name |
columbamine O-methyltransferase
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
 |
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| Sysname |
S-adenosyl-L-methionine:columbamine O-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + palmatine [RN: R03721]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
columbamine [CPD: C01795]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
palmatine [CPD: C05315]
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| Comment |
The product of this reaction is a protoberberine alkaloid that is widely distributed in the plant kingdom. This enzyme is distinct in specificity from EC 2.1.1.88, 8-hydroxyquercetin 8-O-methyltransferase.
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| Pathway |
| Isoquinoline alkaloid biosynthesis |
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| Orthology |
| columbamine O-methyltransferase |
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| Reference |
1 |
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| Authors |
Rueffer, M., Amann, M., Zenk, M.H. |
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| Title |
S-Adenosyl-L-methionine:columbamine O-methyltransferase, a compartmentalized enzyme in protoberberine biosynthesis. |
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| Journal |
Plant Cell Reports 3 (1986) 182-185. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 105843-76-3 |
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