KEGG   ENZYME: 2.1.1.118Help
Entry
EC 2.1.1.118                Enzyme                                 

Name
columbamine O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:columbamine O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + palmatine [RN:R03721]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
columbamine [CPD:C01795]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
palmatine [CPD:C05315]
Comment
The product of this reaction is a protoberberine alkaloid that is widely distributed in the plant kingdom. This enzyme is distinct in specificity from EC 2.1.1.88, 8-hydroxyquercetin 8-O-methyltransferase.
History
EC 2.1.1.118 created 1999
Pathway
Isoquinoline alkaloid biosynthesis
Orthology
K13398  
columbamine O-methyltransferase
Reference
1
  Authors
Rueffer, M., Amann, M., Zenk, M.H.
  Title
S-Adenosyl-L-methionine:columbamine O-methyltransferase, a compartmentalized enzyme in protoberberine biosynthesis.
  Journal
Plant Cell Reports 3 (1986) 182-185.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
105843-76-3

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