KEGG   ENZYME: 2.1.1.129Help
Entry
EC 2.1.1.129                Enzyme                                 

Name
inositol 4-methyltransferase;
myo-inositol 4-O-methyltransferase;
S-adenosyl-L-methionine:myo-inositol 4-O-methyltransferase;
myo-inositol 6-O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:1D-myo-inositol 4-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + myo-inositol = S-adenosyl-L-homocysteine + 1D-4-O-methyl-myo-inositol [RN:R01190]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
myo-inositol [CPD:C00137]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
1D-4-O-methyl-myo-inositol [CPD:C06352]
Comment
The enzyme from the rice bean Vigna umbellata (Fabaceae) is highly specific for S-adenosyl-L-methionine. The enzyme also methylates 1L-1,2,4/3,5-cyclohexanepentol, 2,4,6/3,5-pentahydroxycyclohexanone, D,L-2,3,4,6/5-pentacyclohexanone and 2,2'-anhydro-2-C-hydroxymethyl-myo-inositol, but at lower rates than that of myo-inositol.
History
EC 2.1.1.129 created 1999 (EC 2.1.1.134 created 1999, incorporated 2002), modified 2002
Reference
1  [PMID:1600940]
  Authors
Vernon DM, Bohnert HJ.
  Title
A novel methyl transferase induced by osmotic stress in the facultative halophyte Mesembryanthemum crystallinum.
  Journal
EMBO. J. 11 (1992) 2077-85.
  Sequence
[up:P45986]
Reference
2
  Authors
Wanek, W. and Richter, A.
  Title
Purification and characterization of myo-inositol 6-O-methyltransferase from Vigna umbellata Ohwi et Ohashi.
  Journal
Planta 197 (1995) 427-434.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
169277-48-9

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