| Entry |
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| Name |
3'-demethylstaurosporine O-methyltransferase;
3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase;
staurosporine synthase
|
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
 |
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| Sysname |
S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase
|
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + 3'-demethylstaurosporine = S-adenosyl-L-homocysteine + staurosporine [RN: R05757]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
3'-demethylstaurosporine [CPD: C07349]
|
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
staurosporine [CPD: C02079]
|
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| Comment |
Catalyses the final step in the biosynthesis of staurosporine, an alkaloidal antibiotic that is a potent inhibitor of protein kinases, especially protein kinase C.
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| Reference |
|
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| Authors |
Weidner S, Kittelmann M, Goeke K, Ghisalba O, Zahner H. |
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| Title |
3'-Demethoxy-3'-hydroxystaurosporine-O-methyltransferase from Streptomyces longisporoflavus catalyzing the last step in the biosynthesis of staurosporine. |
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| Journal |
J. Antibiot. (Tokyo). 51 (1998) 679-82. |
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| Organism |
Streptomyces longisporoflavus |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 212906-74-6 |
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