KEGG   ENZYME: 2.1.1.140Help
Entry
EC 2.1.1.140                Enzyme                                 

Name
(S)-coclaurine-N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:(S)-coclaurine-N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine [RN:R04692]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
(S)-coclaurine [CPD:C06161]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(S)-N-methylcoclaurine [CPD:C05176]
Comment
The enzyme is specific for the (S)-isomer of coclaurine. Norcoclaurine can also act as an acceptor.
History
EC 2.1.1.140 created 2001
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13384  (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase
Reference
1
  Authors
Loeffler, S., Deus-Neumann, B. and Zenk, M.H.
  Title
S-Adenosyl-L-methionine: (S)-coclaurine-N-methyltransferase from Tinospora cordifolia.
  Journal
Phytochemistry 38 (1995) 1387-1395.
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.140
IUBMB Enzyme Nomenclature: 2.1.1.140
ExPASy - ENZYME nomenclature database: 2.1.1.140
BRENDA, the Enzyme Database: 2.1.1.140
CAS: 167398-06-3

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