KEGG   ENZYME: 2.1.1.140Help
Entry
EC 2.1.1.140                Enzyme                                 

Name
(S)-coclaurine-N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:(S)-coclaurine-N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine [RN:R04692]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
(S)-coclaurine [CPD:C06161]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(S)-N-methylcoclaurine [CPD:C05176]
Comment
The enzyme is specific for the (S)-isomer of coclaurine. Norcoclaurine can also act as an acceptor.
History
EC 2.1.1.140 created 2001
Pathway
Isoquinoline alkaloid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K13384  
(S)-coclaurine N-methyltransferase
Reference
1
  Authors
Loeffler, S., Deus-Neumann, B. and Zenk, M.H.
  Title
S-Adenosyl-L-methionine: (S)-coclaurine-N-methyltransferase from Tinospora cordifolia.
  Journal
Phytochemistry 38 (1995) 1387-1395.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
167398-06-3

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