KEGG   ENZYME: 2.1.1.140Help
Entry
EC 2.1.1.140                Enzyme                                 

Name
(S)-coclaurine-N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:(S)-coclaurine-N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine [RN:R04692]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
(S)-coclaurine [CPD:C06161]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(S)-N-methylcoclaurine [CPD:C05176]
Comment
The enzyme is specific for the (S)-isomer of coclaurine. Norcoclaurine can also act as an acceptor.
History
EC 2.1.1.140 created 2001
Pathway
Isoquinoline alkaloid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K13384  
(S)-coclaurine N-methyltransferase
Genes
BFO: 
SKO: 
LGI: 
ADF: 
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj1g3v1787600.1(Lj1g3v1787600.1) Lj1g3v1787620.1(Lj1g3v1787620.1) Lj3g3v0419520.1(Lj3g3v0419520.1) Lj3g3v0420540.1(Lj3g3v0420540.1)
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
VVI: 
SLY: 
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
OSA: 
DOSA: 
Os06t0574100-00(Os06g0574100)
OBR: 
BDI: 
ATS: 
SBI: 
SORBI_10g022680(SORBIDRAFT_10g022680)
ZMA: 
100272247(cl52_1b) 103626299(GRMZM2G026258) 103640019(GRMZM2G469839) 103645355(GRMZM2G428673)
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CRE: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
GSL: 
CCP: 
PCO: 
SHS: 
PSQ: 
GTR: 
MRR: 
ABP: 
AGABI1DRAFT70994(AGABI1DRAFT_70994)
ABV: 
AGABI2DRAFT178164(AGABI2DRAFT_178164)
SLA: 
PFP: 
PGR: 
MLR: 
 » show all
Taxonomy
Reference
1
  Authors
Loeffler, S., Deus-Neumann, B. and Zenk, M.H.
  Title
S-Adenosyl-L-methionine: (S)-coclaurine-N-methyltransferase from Tinospora cordifolia.
  Journal
Phytochemistry 38 (1995) 1387-1395.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
167398-06-3

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