KEGG   ENZYME: 2.1.1.142Help
Entry
EC 2.1.1.142                Enzyme                                 

Name
cycloartenol 24-C-methyltransferase;
sterol C-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:cycloartenol 24-C-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + cycloartenol = S-adenosyl-L-homocysteine + (24R)-24-methylcycloart-25-en-3beta-ol [RN:R05760]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
cycloartenol [CPD:C01902]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(24R)-24-methylcycloart-25-en-3beta-ol
Comment
S-Adenosyl-L-methionine methylates the Si face of the 24(25)-double bond with elimination of a hydrogen atom from the pro-Z methyl group at C-25.
History
EC 2.1.1.142 created 2001
Reference
1  [PMID:10882005]
  Authors
Mangla AT, Nes WD.
  Title
Sterol C-methyl transferase from Prototheca wickerhamii mechanism, sterol specificity and inhibition.
  Journal
Bioorg. Med. Chem. 8 (2000) 925-36.
  Organism
Prototheca wickerhamii
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
50936-46-4

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