| Entry |
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| Name |
trans-aconitate 2-methyltransferase
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 2'-O-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-3-(methoxycarbonyl)pent-2-enedioate [RN: R05763]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
trans-aconitate [CPD: C02341]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
(E)-3-(methoxycarbonyl)pent-2-enedioate [CPD: C11514]
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| Comment |
Also catalyses the formation of the methyl monoester of cis-aconitate, isocitrate and citrate, but more slowly. While the enzyme from Escherichia coli forms (E)-3-(methoxycarbonyl)-pent-2-enedioate as the product, that from Saccharomyces cerevisiae forms (E)-2-(methoxycarbonylmethyl)butenedioate and is therefore classified as a separate enzyme (cf. EC 2.1.1.145, trans-aconitate 3-methyltransferase).
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| Orthology |
| trans-aconitate 2-methyltransferase |
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| Genes |
PAN: | | TTT: | | NHE: | | ANI: | | AFV: | | PCS: | | PNO: | | PTE: | | UMA: | | ECO: | | ECJ: | | ECD: | | EBW: | | ECOK: | | ECE: | | ECS: | | ECF: | | ETW: | | ELX: | | EOI: | | EOH: | | ECG: | | EOK: | | ELR: | | ECC: | | ECP: | | ECI: | | ECV: | | ECX: | | ECW: | | ECM: | | ECY: | | ECR: | | ECK: | | ECT: | | EOC: | | EUM: | | ECZ: | | ELO: | | ELN: | | ELH: | | ESE: | | ESO: | | ESM: | | ESL: | | ECL: | | EBR: | | EBD: | | EKO: | | EKF: | | EAB: | | EDH: | | EDJ: | | EIH: | | ENA: | | ELU: | | EUN: | | ELW: | | ELL: | | ELC: | | ELD: | | ELP: | | EBL: | | EBE: | | ELF: | | ECOA: | | EFE: | | YPE: | | YPK: | | YPA: | | YPN: | | YPM: | | YPP: | | YPG: | | YPZ: | | YPT: | | YPD: | | YPX: | | YPS: | | YPI: | | YPY: | | YPB: | | YEN: | | YEP: | | YEY: | | SFL: | | SFX: | | SFV: | | SFE: | | SBC: | | SDY: | | EBI: | | ENT: | | ENC: | | ENO: | | ESC: | | EEC: | | ENL: | | EAS: | | EAE: | | EAR: | | KPN: | | KPU: | | KPM: | | KPP: | | KPE: | | KPO: | | KVA: | | KOX: | | CRO: | | DDA: | | DDC: | | DDD: | | PAM: | | PLF: | | PAJ: | | PAQ: | | PVA: | | PAO: | | ROR: | | PAE: | | PAU: | | PAP: | | PAF: | | PNC: | | PSG: | | PPU: | | PPF: | | PPG: | | PPW: | | PPT: | | PPB: | | PPI: | | PPX: | | PPUH: | | PPUU: | | PFL: | | PFO: | | PFS: | | PFE: | | PFC: | | PPZ: | | PEN: | | PMY: | | PMK: | | PBA: | | LLO: | | RPI: | | REU: | | REH: | | RME: | | CTI: | | CNC: | | BPD: | | BTE: | | BUR: | | BCN: | | BCH: | | BCM: | | BCJ: | | BAM: | | BAC: | | BXE: | | BPY: | | BGE: | | BGD: | | BYI: | | BAV: | | AXY: | | AAV: | | AJS: | | DIA: | | AAA: | | DAC: | | DEL: | | VAP: | | VPE: | | CTT: | | ADN: | | ADK: | | HSE: | | CFU: | | AZO: | | APP: | | AFW: | | MXA: | | MFU: | | MSD: | | CCX: | | SCL: | | MLO: | | MCI: | | MOP: | | MAM: | | SME: | | SMK: | | SMQ: | | SMX: | | SMI: | | SMEG: | | SMEL: | | SMD: | | RHI: | | SFH: | | ATU: | | ARA: | | AGR: | | RET: | | REC: | | RLE: | | RLT: | | RLG: | | RTR: | | BME: | | BMI: | | BMZ: | | BMG: | | BMW: | | BMF: | | BMC: | | BAA: | | BMS: | | BSI: | | BMT: | | BSV: | | BOV: | | BCS: | | BSK: | | BMR: | | BPP: | | OAN: | | BJA: | | BJU: | | BRA: | | BRS: | | RPA: | | RPB: | | RPC: | | RPD: | | RPE: | | RPT: | | RPX: | | NWI: | | NHA: | | OCA: | | OCG: | | OCO: | | XAU: | | AZC: | | SNO: | | MRD: | | MET: | | MNO: | | RVA: | | MSC: | | CAK: | | RSQ: | | RCE: | | RPM: | | MAG: | | ALI: | | ABS: | | TMO: | | CPAS: | | CSS: | | CSD: | | DED: | | DEC: | | AWO: | | EHA: | | MTU: | | MTV: | | MTC: | | MRA: | | MTF: | | MTB: | | MTK: | | MTZ: | | MTI: | | MTE: | | MTL: | | MTO: | | MTD: | | MTN: | | MTJ: | | MTUB: | | MBO: | | MBB: | | MBT: | | MBM: | | MBK: | | MAF: | | MCE: | | MCQ: | | MCV: | | MCX: | | MCZ: | | MPA: | | MAV: | | MIT: | | MIR: | | MIA: | | MID: | | MSM: | | MSG: | | MSA: | | MUL: | | MVA: | | MGI: | | MSP: | | MAB: | | MMV: | | MMC: | | MKM: | | MJL: | | MMI: | | MRH: | | MMM: | | MCB: | | MLI: | | NBR: | | RHA: | | RER: | | ROP: | | GBR: | | GPO: | | GOR: | | TPR: | | SRT: | | SCO: | | SMA: | | SGR: | | SCB: | | SSX: | | SVL: | | SCT: | | SCY: | | SFA: | | SBH: | | SHY: | | SHO: | | SVE: | | SDV: | | SALB: | | STRP: | | SFI: | | KSK: | | ART: | | AAU: | | ACH: | | AAI: | | APN: | | ARR: | | RSA: | | MLU: | | BCV: | | BFA: | | IVA: | | ICA: | | PBO: | | MPH: | | NCA: | | KFL: | | TCU: | | SRO: | | FAL: | | GOB: | | BSD: | | MMAR: | | SEN: | | SVI: | | TBI: | | AMD: | | AMN: | | AMM: | | PDX: | | AMI: | | SESP: | | STP: | | SAQ: | | MAU: | | MIL: | | VMA: | | AMS: | | ASE: | | CAI: | | BLO: | | BLJ: | | BLF: | | BLB: | | BLM: | | BLK: | | BLG: | | BBI: | | RXY: | | SUS: | | CPI: | | PHE: | | SHG: | | DFE: | | FJO: | | SACI: | | ANA: | | NPU: | | AVA: | | DRA: | | DDR: | | DMR: | | DGO: | | DPD: | | MSV: | | MEW: | |
» show all
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| Reference |
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| Authors |
Cai H, Clarke S. |
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| Title |
A novel methyltransferase catalyzes the methyl esterification of trans-aconitate in Escherichia coli. |
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| Journal |
J. Biol. Chem. 274 (1999) 13470-9. |
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| Organism |
Escherichia coli [GN: eco] |
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| Reference |
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| Authors |
Cai H, Strouse J, Dumlao D, Jung ME, Clarke S. |
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| Title |
Distinct reactions catalyzed by bacterial and yeast trans-aconitate methyltransferases. |
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| Journal |
Biochemistry. 40 (2001) 2210-9. |
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| Organism |
Escherichia coli [GN: eco] |
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| Reference |
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| Authors |
Cai H, Dumlao D, Katz JE, Clarke S. |
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| Title |
Identification of the gene and characterization of the activity of the trans-aconitate methyltransferase from Saccharomyces cerevisiae. |
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| Journal |
Biochemistry. 40 (2001) 13699-709. |
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| Organism |
Escherichia coli [GN: eco] |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 235107-12-7 |
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