KEGG   ENZYME: 2.1.1.145Help
Entry
EC 2.1.1.145                Enzyme                                 

Name
trans-aconitate 3-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 3'-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-2-(methoxycarbonylmethyl)butenedioate [RN:R05764]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
trans-aconitate [CPD:C02341]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(E)-2-(methoxycarbonylmethyl)butenedioate [CPD:C11515]
Comment
Also catalyses the formation of the methyl monoester of cis-aconitate, isocitrate and citrate, but more slowly. While the enzyme from Saccharomyces cerevisiae forms (E)-2-(methoxycarbonylmethyl)butenedioate as the product, that from Escherichia coli forms (E)-3-(methoxycarbonyl)-pent-2-enedioate and is therefore classified as a separate enzyme (cf. EC 2.1.1.144, trans-aconitate 2-methyltransferase)
History
EC 2.1.1.145 created 2002
Orthology
K22438  
trans-aconitate 3-methyltransferase
Genes
HRO: 
SCE: 
YER175C(TMT1)
AGO: 
KLA: 
KMX: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A03100(NCAS0A03100) NCAS_0B04900(NCAS0B04900)
NDI: 
NDAI_0B02310(NDAI0B02310) NDAI_0I02680(NDAI0I02680)
TPF: 
TPHA_0A01900(TPHA0A01900)
TBL: 
TBLA_0C01350(TBLA0C01350) TBLA_0C01360(TBLA0C01360) TBLA_0F03870(TBLA0F03870)
TDL: 
TDEL_0G00510(TDEL0G00510) TDEL_0G00520(TDEL0G00520)
KAF: 
KAFR_0B02610(KAFR0B02610) KAFR_0B06440(KAFR0B06440) KAFR_0C00170(KAFR0C00170)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CAALFM_C105830WA(CaO19.2468) CAALFM_C110310WA(CaO19.4902)
CTP: 
COT: 
CDU: 
CTEN: 
CLU: 
CLUS: 
CAUR: 
SLB: 
NCR: 
NTE: 
NEUTE1DRAFT128461(NEUTE1DRAFT_128461)
SMP: 
PAN: 
TTT: 
MTM: 
TMN: 
FGR: 
FVR: 
FOX: 
NHE: 
MAW: 
MAJ: 
CMT: 
PLJ: 
VAL: 
VDA: 
CFJ: 
ELA: 
PFY: 
SSL: 
BFU: 
MBE: 
PSCO: 
GLZ: 
AFM: 
NFI: 
PDP: 
ABE: 
TVE: 
AJE: 
PTE: 
BZE: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
CGI: 
TMS: 
TVS: 
DSQ: 
PCO: 
SHS: 
HIR: 
ADL: 
FME: 
GTR: 
LBC: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT115048(AGABI1DRAFT_115048)
ABV: 
AGABI2DRAFT195435(AGABI2DRAFT_195435)
CPUT: 
SLA: 
WSE: 
WIC: 
PFP: 
PGR: 
MLR: 
 » show all
Taxonomy
Reference
1  [PMID:10224113]
  Authors
Cai H, Clarke S.
  Title
A novel methyltransferase catalyzes the methyl esterification of trans-aconitate in Escherichia coli.
  Journal
J. Biol. Chem. 274 (1999) 13470-9.
Reference
2  [PMID:11329290]
  Authors
Cai H, Strouse J, Dumlao D, Jung ME, Clarke S.
  Title
Distinct reactions catalyzed by bacterial and yeast trans-aconitate methyltransferases.
  Journal
Biochemistry. 40 (2001) 2210-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
235107-12-7

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