KEGG   ENZYME: 2.1.1.145Help
Entry
EC 2.1.1.145                Enzyme                                 

Name
trans-aconitate 3-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 3'-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-2-(methoxycarbonylmethyl)butenedioate [RN:R05764]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
trans-aconitate [CPD:C02341]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(E)-2-(methoxycarbonylmethyl)butenedioate [CPD:C11515]
Comment
Also catalyses the formation of the methyl monoester of cis-aconitate, isocitrate and citrate, but more slowly. While the enzyme from Saccharomyces cerevisiae forms (E)-2-(methoxycarbonylmethyl)butenedioate as the product, that from Escherichia coli forms (E)-3-(methoxycarbonyl)-pent-2-enedioate and is therefore classified as a separate enzyme (cf. EC 2.1.1.144, trans-aconitate 2-methyltransferase)
History
EC 2.1.1.145 created 2002
Reference
1  [PMID:10224113]
  Authors
Cai H, Clarke S.
  Title
A novel methyltransferase catalyzes the methyl esterification of trans-aconitate in Escherichia coli.
  Journal
J. Biol. Chem. 274 (1999) 13470-9.
Reference
2  [PMID:11329290]
  Authors
Cai H, Strouse J, Dumlao D, Jung ME, Clarke S.
  Title
Distinct reactions catalyzed by bacterial and yeast trans-aconitate methyltransferases.
  Journal
Biochemistry. 40 (2001) 2210-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
235107-12-7

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