KEGG   ENZYME: 2.1.1.147Help
Entry
EC 2.1.1.147                Enzyme                                 

Name
corydaline synthase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + palmatine + 2 NADPH + H+ = S-adenosyl-L-homocysteine + corydaline + 2 NADP+ [RN:R07241]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
palmatine [CPD:C05315];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
corydaline [CPD:C15530];
NADP+ [CPD:C00006]
Comment
Also acts on 7,8-dihydropalmatine.
History
EC 2.1.1.147 created 2002
Pathway
Isoquinoline alkaloid biosynthesis
Reference
1
  Authors
Rueffer, M., Bauer, W. and Zenk, M.H.
  Title
The formation of corydaline and related alkaloids in Corydalis cava in vivo and in vitro.
  Journal
Canad. J. Chem. 72 (1994) 170-175.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
155807-67-3

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