KEGG   ENZYME: 2.1.1.155Help
Entry
EC 2.1.1.155                Enzyme                                 

Name
kaempferol 4'-O-methyltransferase;
S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase;
F 4'-OMT
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:kaempferol 4'-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + kaempferol = S-adenosyl-L-homocysteine + kaempferide [RN:R06807]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
kaempferol [CPD:C05903]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
kaempferide [CPD:C10098]
Comment
The enzyme acts on the hydroxy group in the 4'-position of some flavones, flavanones and isoflavones. Kaempferol, apigenin and kaempferol triglucoside are substrates, as is genistein, which reacts more slowly. Compounds with an hydroxy group in the 3' and 4' positions, such as quercetin and eriodictyol, do not act as substrates. Similar to EC 2.1.1.75, apigenin 4'-O-methyltransferase and EC 2.1.1.83, 3,7-dimethylquercetin 4'-O-methyltransferase.
History
EC 2.1.1.155 created 2004
Pathway
Flavone and flavonol biosynthesis
Reference
1  [PMID:12899699]
  Authors
Curir P, Lanzotti V, Dolci M, Dolci P, Pasini C, Tollin G.
  Title
Purification and properties of a new S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase from carnation (Dianthus caryophyllus L.).
  Journal
Eur. J. Biochem. 270 (2003) 3422-31.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
80747-20-2

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