KEGG   ENZYME: 2.1.1.161Help
Entry
EC 2.1.1.161                Enzyme                                 

Name
dimethylglycine N-methyltransferase;
BsmB;
DMT
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase (betaine-forming)
Reaction(IUBMB)
S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine [RN:R07244]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
N,N-dimethylglycine [CPD:C01026]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
betaine [CPD:C00719]
Comment
This enzyme, from the marine cyanobacterium Synechococcus sp. WH8102, differs from EC 2.1.1.157, sarcosine/dimethylglycine N-methyltransferase in that it cannot use sarcosine as an alternative substrate [1]. Betaine is a 'compatible solute' that enables cyanobacteria to cope with osmotic stress by maintaining a positive cellular turgor.
History
EC 2.1.1.161 created 2007
Orthology
K13042  
dimethylglycine N-methyltransferase
Genes
TGR: 
SYW: 
SYNW1913(sdmt)
SYX: 
PMT: 
PMT0551(sdmt)
PMF: 
CTS: 
Taxonomy
Reference
1  [PMID:17019606]
  Authors
Lu WD, Chi ZM, Su CD.
  Title
Identification of glycine betaine as compatible solute in Synechococcus sp. WH8102 and characterization of its N-methyltransferase genes involved in betaine synthesis.
  Journal
Arch. Microbiol. 186 (2006) 495-506.
  Sequence
[syw:SYNW1913]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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