KEGG   ENZYME: 2.1.1.164Help
Entry
EC 2.1.1.164                Enzyme                                 

Name
demethylrebeccamycin-D-glucose O-methyltransferase;
RebM
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:demethylrebeccamycin-D-glucose O-methyltransferase
Reaction(IUBMB)
4'-demethylrebeccamycin + S-adenosyl-L-methionine = rebeccamycin + S-adenosyl-L-homocysteine [RN:R09569]
Reaction(KEGG)
Substrate
4'-demethylrebeccamycin;
S-adenosyl-L-methionine [CPD:C00019]
Product
rebeccamycin [CPD:C19701];
S-adenosyl-L-homocysteine [CPD:C00021]
Comment
Catalyses the last step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is able to use a wide variety substrates, tolerating variation on the imide heterocycle, deoxygenation of the sugar moiety, and even indolocarbazole glycoside anomers [1]. The enzyme is a member of the general acid/base-dependent O-methyltransferase family [2].
History
EC 2.1.1.164 created 2010
Reference
1  [PMID:16575939]
  Authors
Zhang C, Albermann C, Fu X, Peters NR, Chisholm JD, Zhang G, Gilbert EJ, Wang PG, Van Vranken DL, Thorson JS
  Title
RebG- and RebM-catalyzed indolocarbazole diversification.
  Journal
Chembiochem. 7 (2006) 795-804.
  Sequence
[up:Q8KZ94]
Reference
2  [PMID:18502766]
  Authors
Singh S, McCoy JG, Zhang C, Bingman CA, Phillips GN Jr, Thorson JS
  Title
Structure and mechanism of the rebeccamycin sugar 4'-O-methyltransferase RebM.
  Journal
J. Biol. Chem. 283 (2008) 22628-36.
  Sequence
[up:Q8KZ94]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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