KEGG   ENZYME: 2.1.1.167Help
Entry
EC 2.1.1.167                Enzyme                                 

Name
27S pre-rRNA (guanosine2922-2'-O)-methyltransferase;
Spb1p (gene name);
YCL054W (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:27S pre-rRNA (guanosine2922-2'-O-)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + guanosine2922 in 27S pre-rRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine2922 in 27S pre-rRNA
Substrate
S-adenosyl-L-methionine [CPD:C00019];
guanosine2922 in 27S pre-rRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
2'-O-methylguanosine2922 in 27S pre-rRNA
Comment
Spb1p is a site-specific 2'-O-ribose RNA methyltransferase that catalyses the formation of 2'-O-methylguanosine2922, a universally conserved position of the catalytic center of the ribosome that is essential for translation. 2'-O-Methylguanosine2922 is formed at a later stage of the processing, during the maturation of of the 27S pre-rRNA. In absence of snR52, Spb1p can also catalyse the formation of uridine2921 [1].
History
EC 2.1.1.167 created 2010
Reference
1  [PMID:15546625]
  Authors
Lapeyre B, Purushothaman SK
  Title
Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stage.
  Journal
Mol. Cell. 16 (2004) 663-9.
  Sequence
[sce:YCL054W]
Reference
2  [PMID:14636587]
  Authors
Bonnerot C, Pintard L, Lutfalla G
  Title
Functional redundancy of Spb1p and a snR52-dependent mechanism for the 2'-O-ribose methylation of a conserved rRNA position in yeast.
  Journal
Mol. Cell. 12 (2003) 1309-15.
  Sequence
[sce:YCL054W]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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