| Entry |
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| Name |
cobalt-precorrin-5B (C1)-methyltransferase;
cobalt-precorrin-6A synthase;
CbiD
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:cobalt-precorrin-5B (C1)-methyltransferase
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| Reaction(IUBMB) |
cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine [RN: R07773]
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| Reaction(KEGG) |
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| Substrate |
cobalt-precorrin-5B;
S-adenosyl-L-methionine [CPD: C00019]
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| Product |
cobalt-precorrin-6A;
S-adenosyl-L-homocysteine [CPD: C00021]
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| Comment |
This enzyme catalyses the C-1 methylation of cobalt-precorrin-5B in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis.
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| History |
EC 2.1.1.195 created 2010
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| Pathway |
| Porphyrin and chlorophyll metabolism | | Metabolic pathways |
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| Orthology |
| cobalt-precorrin-5B (C1)-methyltransferase |
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| Genes |
STY: | | STT: | | SEX: | | SENT: | | STM: | | SEO: | | SEV: | | SEY: | | SEM: | | SEJ: | | SEB: | | SEF: | | SETU: | | SETC: | | SENR: | | SEND: | | SENI: | | SEEN: | | SPT: | | SEK: | | SPQ: | | SEI: | | SEC: | | SEH: | | SHB: | | SENH: | | SEEH: | | SEE: | | SENN: | | SEW: | | SEA: | | SENS: | | SED: | | SEL: | | SEGA: | | SET: | | SENA: | | SENO: | | SENV: | | SENQ: | | SENL: | | SENJ: | | SEEC: | | SEEB: | | SEEP: | | SENB: | | SENE: | | SENC: | | SES: | | ESC: | | KLE: | | ENR: | | ENF: | | KPN: | | KPU: | | KPM: | | KPP: | | KPH: | | KPZ: | | KPV: | | KPW: | | KPY: | | KPG: | | KPC: | | KPQ: | | KPT: | | KPE: | | KPO: | | KPR: | | KPI: | | KPA: | | KPS: | | KPX: | | KPB: | | KPNE: | | KPNU: | | KVA: | | KVD: | | KVQ: | | KOX: | | KOE: | | KOY: | | KOK: | | KOC: | | KOM: | | KQU: | | CKO: | | CRO: | | CFD: | | CBRA: | | CAMA: | | CAF: | | CIF: | | EBT: | | PGE: | | KSA: | | KOR: | | KRD: | | KIN: | | EBF: | | YEN: | | YEP: | | YEY: | | YEL: | | YEW: | | YET: | | YEF: | | YEE: | | YAL: | | YFR: | | YIN: | | YKR: | | YRO: | | YAK: | | PLU: | | PAY: | | PTT: | | XBO: | | XBV: | | XNE: | | XNM: | | MMK: | | EIC: | | ETR: | | ETD: | | ETE: | | ETC: | | EDW: | | EDL: | | EHO: | | HAV: | | OPO: | | FAU: | | VSP: | | VNI: | | PAE: | | PAEV: | | PAEI: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PAEB: | | PDK: | | PSG: | | PRP: | | PAEP: | | PAER: | | PAEM: | | PAEL: | | PAES: | | PAEU: | | PAEG: | | PAEC: | | PAEO: | | PRE: | | PPU: | | PPF: | | PPG: | | PPW: | | PPT: | | PPB: | | PPI: | | PPX: | | PPUH: | | PPUT: | | PPUN: | | PPUD: | | PMON: | | PMOT: | | PMOS: | | PPJ: | | POR: | | PST: | | PSB: | | PSYR: | | PSP: | | PCI: | | PFL: | | PPRC: | | PPRO: | | PFO: | | PFE: | | PMAN: | | PCG: | | PEN: | | PBA: | | PBC: | | PPUU: | | PDR: | | PSV: | | PCH: | | PCZ: | | PCP: | | PFZ: | | PALK: | | PRH: | | PSW: | | PPV: | | PSES: | | PSEM: | | PSEC: | | PPSY: | | PSOS: | | PKR: | | PFK: | | SSE: | | MVS: | | SPOI: | | ZAL: | | MCA: | | MDN: | | MAH: | | HHA: | | HHC: | | TKM: | | TVR: | | EBS: | | HCH: | | EME: | | KUS: | | KMA: | | MMW: | | MME: | | MPC: | | OAI: | | GSN: | | TAU: | | CVI: | | CVC: | | PSE: | | RSO: | | RSL: | | RSN: | | RSM: | | RSE: | | BMA: | | BMV: | | BMAL: | | BMAE: | | BMAQ: | | BMAI: | | BMAF: | | BMAZ: | | BMAB: | | BPS: | | BPM: | | BPL: | | BPD: | | BPR: | | BPSE: | | BPSM: | | BPSU: | | BPSD: | | BPZ: | | BPQ: | | BPK: | | BPSH: | | BPSA: | | BPSO: | | BUT: | | BTE: | | BTJ: | | BTZ: | | BTD: | | BTV: | | BTHE: | | BTHM: | | BTHA: | | BTHL: | | BOK: | | BOC: | | BVI: | | BVE: | | BUR: | | BCN: | | BCH: | | BCM: | | BCJ: | | BCEN: | | BCEW: | | BCEO: | | BAM: | | BAC: | | BMU: | | BMJ: | | BMK: | | BMUL: | | BCT: | | BCED: | | BCEP: | | BDL: | | BPYR: | | BCON: | | BUB: | | BDF: | | BLAT: | | BTEI: | | BUG: | | BGE: | | BGF: | | BYI: | | BUK: | | BUO: | | BUE: | | BUL: | | BUQ: | | BUD: | | BXE: | | BXB: | | BPH: | | BPX: | | BPY: | | BCAI: | | PSPW: | | POL: | | PNA: | | AAV: | | AAA: | | VAP: | | OTO: | | MPT: | | HSE: | | HSZ: | | HHT: | | HRB: | | MNR: | | RDP: | | PBH: | | DSU: | | RBU: | | DAR: | | AZO: | | AZA: | | AZI: | | TMZ: | | THU: | | TCL: | | APP: | | ANT: | | SBA: | | SMUL: | | SHAL: | | GSU: | | GSK: | | GME: | | GUR: | | GLO: | | GBM: | | GEO: | | GEM: | | GEB: | | GPI: | | GAO: | | GSB: | | PCA: | | PPD: | | PEF: | | DES: | | DEU: | | DVU: | | DVL: | | DVM: | | DVG: | | DDE: | | DDS: | | DDN: | | DMA: | | DSA: | | DAS: | | DAF: | | DHY: | | DPI: | | DGG: | | DFI: | | DEJ: | | DPG: | | DBA: | | DOA: | | DPS: | | DAK: | | DPR: | | DSF: | | DML: | | DAL: | | DAT: | | DTO: | | SCL: | | SCU: | | DAO: | | DTI: | | SFU: | | DBR: | | HMR: | | HOE: | | AAK: | | ATU: | | ATF: | | ATA: | | AVI: | | AGR: | | AGC: | | RIR: | | RHT: | | NGL: | | NGG: | | BME: | | BMEL: | | BMI: | | BMZ: | | BMG: | | BMW: | | BMEE: | | BMF: | | BMB: | | BMC: | | BAA: | | BABO: | | BABR: | | BABT: | | BABB: | | BABU: | | BABS: | | BABC: | | BMS: | | BSI: | | BSF: | | BSUI: | | BSUP: | | BSUV: | | BSUC: | | BSZ: | | BSV: | | BSW: | | BSG: | | BOV: | | BCS: | | BSK: | | BOL: | | BCAR: | | BCAS: | | BMR: | | BPP: | | BPV: | | BCET: | | BCEE: | | BVL: | | OAN: | | OAH: | | OPS: | | BRA: | | BBT: | | AOL: | | BOP: | | XAU: | | AZC: | | MCH: | | MET: | | MNO: | | MAQU: | | BID: | | HMC: | | DEQ: | | MSC: | | MBRY: | | AUA: | | MCG: | | RBM: | | DSH: | | PSF: | | OAT: | | OAR: | | OTM: | | PTP: | | CMAR: | | HAT: | | LAP: | | LAGG: | | DON: | | RMM: | | GOH: | | GBE: | | GBH: | | GBC: | | GBS: | | GXY: | | GXL: | | KNA: | | APT: | | APW: | | APF: | | APU: | | APG: | | APQ: | | APX: | | APZ: | | APK: | | ASV: | | APER: | | ABG: | | RGI: | | RRU: | | RRF: | | MAG: | | MGY: | | MAGX: | | MAGN: | | AZL: | | ALI: | | ABS: | | ABQ: | | ABF: | | ATI: | | TMO: | | TXI: | | MAGQ: | | MGM: | | PGV: | | APB: | | BMQ: | | BMD: | | BMEG: | | BACI: | | BACO: | | BSJ: | | BON: | | BWH: | | GKA: | | GTE: | | GTK: | | GTN: | | GWC: | | GYC: | | GYA: | | GCT: | | GMC: | | GGH: | | GJF: | | GEA: | | GEL: | | GSE: | | GSR: | | GTH: | | PTL: | | AFL: | | AGN: | | ANM: | | AAMY: | | ANL: | | LSP: | | LGY: | | LFU: | | LMO: | | LMF: | | LMH: | | LMC: | | LMN: | | LMY: | | LMT: | | LMG: | | LMS: | | LMJ: | | LMQ: | | LML: | | LMP: | | LMW: | | LMX: | | LMZ: | | LMON: | | LMOC: | | LMOS: | | LMOO: | | LMOY: | | LMOT: | | LMOA: | | LMOL: | | LMOG: | | LMOE: | | LMOB: | | LMOJ: | | LMOZ: | | LMOD: | | LMOW: | | LMOX: | | LMOQ: | | LMR: | | LMOK: | | LMV: | | LMOM: | | LIN: | | LWE: | | LSG: | | LIV: | | LII: | | LIW: | | LIA: | | LIO: | | BBE: | | BLR: | | PPY: | | PPM: | | PPO: | | PPOL: | | PPQ: | | PPOY: | | PMS: | | PMQ: | | PMW: | | PTA: | | PLV: | | PSAB: | | PDU: | | PBD: | | PGM: | | PAEN: | | PAEQ: | | PAEA: | | PAEE: | | PAEH: | | PBJ: | | PRI: | | PPEO: | | PNP: | | ANX: | | BTS: | | SSIL: | | KUR: | | SPOR: | | SPOP: | | SSA: | | SIP: | | LRE: | | LRF: | | LRU: | | LGN: | | LPD: | | PCE: | | AUR: | | AUN: | | CAC: | | CAE: | | CAY: | | CPE: | | CPF: | | CPR: | | CTC: | | CTET: | | CNO: | | CBO: | | CBA: | | CBH: | | CBY: | | CBL: | | CBK: | | CBB: | | CBI: | | CBN: | | CBT: | | CBF: | | CBM: | | CBJ: | | CBE: | | CBZ: | | CBEI: | | CKL: | | CKR: | | CLJ: | | CCB: | | CLS: | | CLB: | | CSR: | | CPAS: | | CPAT: | | CPAE: | | CSB: | | CAH: | | CLT: | | CBV: | | CSQ: | | CLD: | | CACE: | | CCK: | | CBUT: | | CTYK: | | CEU: | | AMT: | | AOE: | | GFE: | | CCE: | | CCL: | | RUM: | | FPR: | | FPA: | | BPB: | | BFI: | | BHU: | | RHO: | | RIX: | | RIM: | | CCT: | | ROB: | | BYL: | | RTO: | | CPY: | | LACY: | | CSH: | | ERE: | | ERT: | | ERA: | | CDF: | | PDC: | | CDC: | | CDL: | | PDF: | | EAC: | | CST: | | SLP: | | DSY: | | DHD: | | DDH: | | DDL: | | DMT: | | DRM: | | DAE: | | DCA: | | DKU: | | DRU: | | DGI: | | DFG: | | PTH: | | DAU: | | TJR: | | SGY: | | DOR: | | DAI: | | DMI: | | DED: | | DEC: | | DRS: | | HMO: | | EEL: | | ELM: | | AWO: | | SAY: | | SAP: | | CAD: | | IBU: | | FPLA: | | EUU: | | BPRS: | | TEX: | | THX: | | TIT: | | TMT: | | TKI: | | TEP: | | TAE: | | MTA: | | TPZ: | | TOC: | | TTM: | | TSH: | | NTH: | | HAS: | | HPK: | | AAR: | | VPR: | | VAT: | | MED: | | SSG: | | SRI: | | SELE: | | SELO: | | SELT: | | MHG: | | PUF: | | PFT: | | SGR: | | SGB: | | SCB: | | SSX: | | SVL: | | SCT: | | SCY: | | SFA: | | SBH: | | SVE: | | SALS: | | STRP: | | SFI: | | SRC: | | SALU: | | SALL: | | SVT: | | STRE: | | SCW: | | SLD: | | STRC: | | SPRI: | | SCZ: | | STRF: | | SLE: | | SRN: | | SPAV: | | SLC: | | SCLF: | | SNR: | | KSK: | | ARS: | | PFR: | | PFRE: | | PPC: | | TFA: | | TEZ: | | TCU: | | SRO: | | FRE: | | FSY: | | GOB: | | BSD: | | MMAR: | | SEN: | | AMQ: | | KAL: | | ALL: | | STP: | | SAQ: | | RXY: | | RRD: | | AFO: | | SYN: | | SYZ: | | SYY: | | SYT: | | SYS: | | SYQ: | | SYJ: | | SYW: | | SYC: | | SYF: | | SYD: | | SYE: | | SYG: | | SYR: | | SYX: | | CYA: | | CYB: | | SYNE: | | SYNP: | | SYNK: | | SYNR: | | SYND: | | SYU: | | SYH: | | TEL: | | THN: | | CGC: | | DSL: | | CMP: | | LEN: | | LET: | | LBO: | | PSEU: | | PMA: | | PMM: | | PMT: | | PMN: | | PMI: | | PMB: | | PMC: | | PMF: | | PMG: | | PMH: | | PMJ: | | PME: | | PRC: | | PRM: | | AMR: | | MAR: | | MPK: | | CAN: | | CSN: | | HAO: | | CYU: | | GLP: | | GEN: | | GEE: | | CYT: | | CYP: | | CYC: | | CYN: | | CYH: | | CYJ: | | TER: | | MIC: | | ARP: | | GEI: | | OAC: | | ONI: | | MPRO: | | CEP: | | GVI: | | ANA: | | NPU: | | NOS: | | NOP: | | NON: | | AVA: | | ANB: | | ACY: | | AWA: | | NAZ: | | CSG: | | CALO: | | CALT: | | CALH: | | RIV: | | FIS: | | CTHE: | | PLP: | | SCS: | | DFO: | | RRS: | | RCA: | | CAU: | | CAG: | | CHL: | | ABAO: | | CAP: | | DGE: | | DDR: | | DMR: | | DGO: | | DPD: | | TTH: | | TTJ: | | TTS: | | TTL: | | TOS: | | TAQ: | | TPAR: | | AGL: | | SACI: | | TDE: | | TPI: | | TPED: | | TPK: | | SSM: | | LIL: | | LIE: | | LIC: | | LIS: | | LBJ: | | LBL: | | LST: | | LAJ: | | FNU: | | FNC: | | FNT: | | FUS: | | FNE: | | FHW: | | IPO: | | LBA: | | LEO: | | LOT: | | STR: | | TAI: | | CPOR: | | BFR: | | BFS: | | BFG: | | BFB: | | BVU: | | BHL: | | BDO: | | BDH: | | BCEL: | | PGI: | | PGN: | | PGT: | | PAH: | | PPN: | | PDI: | | TFO: | | TOH: | | PSAC: | | OSP: | | PRU: | | DORI: | | CPI: | | FCO: | | TDI: | | CTE: | | CPC: | | CLZ: | | PAA: | | PROC: | | PRS: | | CTS: | | TTK: | | TME: | | TAF: | | DIN: | | DDF: | | DAP: | | CNI: | | NDE: | | NMV: | | LFC: | | LFI: | | LFP: | | LEG: | | TID: | | MJA: | | MFE: | | MVU: | | MFS: | | MIF: | | MJH: | | MIG: | | MMP: | | MMQ: | | MMX: | | MMZ: | | MMD: | | MMAK: | | MMAO: | | MAE: | | MVN: | | MVO: | | MOK: | | MAC: | | MBA: | | MBY: | | MBW: | | MBAR: | | MBAK: | | MMA: | | MMAZ: | | MMJ: | | MMAC: | | MVC: | | MEK: | | MLS: | | METM: | | MEF: | | MEQ: | | MSJ: | | MSZ: | | MSW: | | MTHE: | | MTHR: | | MHOR: | | MBU: | | MMET: | | MMH: | | MHAZ: | | MEV: | | MZH: | | MPY: | | MHZ: | | MTP: | | MCJ: | | MHI: | | MHU: | | MLA: | | MEM: | | MBG: | | MEMA: | | MPI: | | MBN: | | MFO: | | MPL: | | MEZ: | | MTH: | | MMG: | | METC: | | MWO: | | MST: | | MSI: | | MRU: | | MEB: | | MMIL: | | MEYE: | | MOL: | | MEL: | | MEW: | | METH: | | MFC: | | MFI: | | MCUB: | | MFV: | | MKA: | | AFU: | | AFG: | | AVE: | | AST: | | FPL: | | GAC: | | GAH: | | TAC: | | TVO: | | PTO: | | FAC: | | FAI: | | TAR: | | MAX: | | MER: | | MEAR: | | MARC: | | SSO: | | SOL: | | SSOA: | | SSOL: | | SSOF: | | STO: | | SAI: | | SACN: | | SACR: | | SACS: | | SIS: | | SIA: | | SIM: | | SID: | | SIY: | | SIN: | | SII: | | SIH: | | SIR: | | SIC: | | SULA: | | MSE: | | MCN: | | AHO: | | AMAN: | | PAI: | | PCL: | | POG: | | TNE: | | PYW: | | TTN: | | VDI: | | NMR: | | NIR: | | NID: | | NIN: | | NKR: | | NCT: | | CSY: | | NGA: | | NVN: | | NEV: | | TAA: | | NBV: | | TAH: | |
» show all
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| Reference |
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| Authors |
Roper JM, Raux E, Brindley AA, Schubert HL, Gharbia SE, Shah HN, Warren MJ |
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| Title |
The enigma of cobalamin (Vitamin B12) biosynthesis in Porphyromonas gingivalis. Identification and characterization of a functional corrin pathway. |
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| Journal |
J. Biol. Chem. 275 (2000) 40316-23. |
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| Reference |
|
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| Authors |
Roessner CA, Williams HJ, Scott AI |
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| Title |
Genetically engineered production of 1-desmethylcobyrinic acid, 1-desmethylcobyrinic acid a,c-diamide, and cobyrinic acid a,c-diamide in Escherichia coli implies a role for CbiD in C-1 methylation in the anaerobic pathway to cobalamin. |
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| Journal |
J. Biol. Chem. 280 (2005) 16748-53. |
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| Reference |
|
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| Authors |
Moore SJ, Lawrence AD, Biedendieck R, Deery E, Frank S, Howard MJ, Rigby SE, Warren MJ |
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| Title |
Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12). |
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| Journal |
Proc. Natl. Acad. Sci. U. S. A. 110 (2013) 14906-11. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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