| Entry |
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| Name |
cobalt-precorrin-5B (C1)-methyltransferase;
cobalt-precorrin-6A synthase;
CbiD
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:cobalt-precorrin-5B (C1)-methyltransferase
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| Reaction(IUBMB) |
cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine [RN: R07773]
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| Reaction(KEGG) |
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| Substrate |
cobalt-precorrin-5B;
S-adenosyl-L-methionine [CPD: C00019]
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| Product |
cobalt-precorrin-6A;
S-adenosyl-L-homocysteine [CPD: C00021]
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| Comment |
This enzyme catalyses the C-1 methylation of cobalt-precorrin-5B in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis.
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| History |
EC 2.1.1.195 created 2010
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| Pathway |
| Porphyrin and chlorophyll metabolism | | Metabolic pathways |
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| Orthology |
| cobalt-precorrin-5B (C1)-methyltransferase |
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| Genes |
STY: | | STT: | | SEX: | | SENT: | | STM: | | SEO: | | SEV: | | SEY: | | SEM: | | SEJ: | | SEB: | | SEF: | | SETU: | | SETC: | | SEEN: | | SENR: | | SEND: | | SPT: | | SEK: | | SPQ: | | SEI: | | SEC: | | SEH: | | SHB: | | SENH: | | SEEH: | | SEE: | | SENN: | | SEW: | | SEA: | | SENS: | | SED: | | SEL: | | SEGA: | | SET: | | SENJ: | | SEEC: | | SEEB: | | SEEP: | | SENB: | | SENE: | | SES: | | YEN: | | YEP: | | YEY: | | PLU: | | PAY: | | ESC: | | ENR: | | KPN: | | KPU: | | KPM: | | KPP: | | KPE: | | KPO: | | KPR: | | KPI: | | KVA: | | KOX: | | KOE: | | CKO: | | CRO: | | CFD: | | EIC: | | ETR: | | ETD: | | ETC: | | XBO: | | XNE: | | EBT: | | MMK: | | EBF: | | FAU: | | VSP: | | VNI: | | PAE: | | PAEV: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PDK: | | PSG: | | PRP: | | PAEP: | | PAER: | | PAEM: | | PAEL: | | PAES: | | PAEU: | | PAEG: | | PAEC: | | PPU: | | PPF: | | PPG: | | PPW: | | PPT: | | PPB: | | PPI: | | PPX: | | PPUH: | | PPUT: | | PPUN: | | PPUU: | | PST: | | PSB: | | PSYR: | | PSP: | | PCI: | | PFL: | | PPRC: | | PFO: | | PFE: | | PEN: | | PBA: | | PDR: | | PRE: | | PSV: | | PMON: | | PMOT: | | SSE: | | MCA: | | MAH: | | HHA: | | HHC: | | TKM: | | HCH: | | MMW: | | MME: | | MPC: | | TAU: | | CVI: | | PSE: | | RSO: | | RSL: | | RSN: | | RSM: | | RSE: | | BMA: | | BMV: | | BML: | | BPS: | | BPM: | | BPL: | | BPD: | | BPR: | | BPSE: | | BPSU: | | BPZ: | | BPQ: | | BPK: | | BTE: | | BTJ: | | BTZ: | | BTD: | | BVI: | | BUR: | | BCN: | | BCH: | | BCM: | | BCJ: | | BAM: | | BAC: | | BMU: | | BMJ: | | BCT: | | BXE: | | BPH: | | BPY: | | BUG: | | BGE: | | BGF: | | BYI: | | BUK: | | BPX: | | BUO: | | POL: | | PNA: | | AAV: | | AAA: | | VAP: | | MPT: | | HSE: | | AZO: | | AZA: | | DAR: | | TMZ: | | DSU: | | APP: | | ANT: | | SBA: | | SMUL: | | GSU: | | GSK: | | GME: | | GUR: | | GLO: | | GBM: | | GEO: | | GEM: | | GEB: | | PCA: | | PPD: | | DVU: | | DVL: | | DVM: | | DVG: | | DDE: | | DDS: | | DDN: | | DMA: | | DSA: | | DAS: | | DAF: | | DHY: | | DPI: | | DGG: | | DBA: | | DPS: | | DAK: | | DPR: | | DSF: | | DAL: | | DAT: | | DTO: | | SCL: | | SCU: | | DAO: | | DTI: | | SFU: | | DBR: | | HMR: | | ATU: | | AVI: | | AGR: | | RIR: | | BME: | | BMI: | | BMZ: | | BMG: | | BMW: | | BMF: | | BMB: | | BMC: | | BAA: | | BMS: | | BSI: | | BSV: | | BOV: | | BCS: | | BSK: | | BOL: | | BMR: | | BPP: | | BCET: | | BCEE: | | OAN: | | BRA: | | BBT: | | AOL: | | XAU: | | AZC: | | MCH: | | MET: | | MNO: | | BID: | | HMC: | | MSC: | | DSH: | | PSF: | | OAT: | | OAR: | | GOH: | | GBE: | | GBH: | | GXY: | | GXL: | | APT: | | APW: | | APF: | | APU: | | APG: | | APQ: | | APX: | | APZ: | | APK: | | RRU: | | RRF: | | MAG: | | MGY: | | AZL: | | ALI: | | ABS: | | TMO: | | MGM: | | PGV: | | APB: | | BSUB: | | BMQ: | | BMD: | | BACI: | | GKA: | | GTN: | | GTH: | | GTE: | | GWC: | | GYC: | | GYA: | | GCT: | | GMC: | | GGH: | | GJF: | | AFL: | | LSP: | | LGY: | | LMO: | | LMF: | | LMH: | | LMC: | | LMN: | | LMY: | | LMT: | | LMG: | | LMS: | | LMJ: | | LMQ: | | LML: | | LMP: | | LMW: | | LMX: | | LMZ: | | LMON: | | LMOC: | | LMOS: | | LMOO: | | LMOY: | | LMOT: | | LMOA: | | LMOL: | | LMOG: | | LMOE: | | LMOB: | | LMOJ: | | LMOZ: | | LMOD: | | LMOW: | | LIN: | | LWE: | | LSG: | | LIV: | | LIW: | | BBE: | | PPY: | | PPM: | | PPO: | | PPOL: | | PMS: | | PMQ: | | PMW: | | PTA: | | PLV: | | PSAB: | | BTS: | | SSA: | | SIP: | | LRE: | | LRF: | | LRU: | | PCE: | | AUR: | | CAC: | | CAE: | | CAY: | | CPE: | | CPF: | | CPR: | | CTC: | | CTET: | | CNO: | | CBO: | | CBA: | | CBH: | | CBY: | | CBL: | | CBK: | | CBB: | | CBI: | | CBN: | | CBT: | | CBF: | | CBM: | | CBJ: | | CBE: | | CKL: | | CKR: | | CCE: | | CLJ: | | CCB: | | CLS: | | CLB: | | CSR: | | CPAS: | | CSB: | | CAH: | | AMT: | | AOE: | | CCL: | | RUM: | | FPR: | | FPA: | | BPB: | | BFI: | | RHO: | | RIX: | | RIM: | | CCT: | | ROB: | | RTO: | | CPY: | | CSH: | | CAD: | | CDF: | | CDC: | | CDL: | | CDG: | | CST: | | SLP: | | DSY: | | DHD: | | DDH: | | DDL: | | DRM: | | DAE: | | DCA: | | DKU: | | DRU: | | DGI: | | PTH: | | DAU: | | TJR: | | SGY: | | DOR: | | DAI: | | DMI: | | DED: | | DEC: | | DRS: | | HMO: | | EEL: | | ERE: | | ERT: | | ERA: | | ELM: | | EAC: | | AWO: | | SAY: | | SAP: | | BPRS: | | TEX: | | THX: | | TIT: | | TMT: | | TEP: | | TAE: | | MTA: | | TPZ: | | TOC: | | TTM: | | TSH: | | NTH: | | HAS: | | HPK: | | AAR: | | VPR: | | SSG: | | SRI: | | MED: | | MHG: | | SGR: | | SCB: | | SSX: | | SVL: | | SCT: | | SCY: | | SFA: | | SBH: | | SVE: | | STRP: | | SFI: | | SRC: | | SALU: | | KSK: | | PFR: | | PPC: | | TCU: | | SRO: | | FRE: | | FSY: | | GOB: | | BSD: | | MMAR: | | SEN: | | KAL: | | STP: | | SAQ: | | RXY: | | RRD: | | AFO: | | TDE: | | TPI: | | TPED: | | SSM: | | LIL: | | LIE: | | LIC: | | LBJ: | | LBL: | | FNU: | | FNC: | | FUS: | | IPO: | | LBA: | | STR: | | TAI: | | SACI: | | SYN: | | SYZ: | | SYY: | | SYT: | | SYS: | | SYQ: | | SYW: | | SYC: | | SYF: | | SYD: | | SYE: | | SYG: | | SYR: | | SYX: | | CYA: | | CYB: | | SYNE: | | SYNP: | | TEL: | | THN: | | MAR: | | CYT: | | CYP: | | CYC: | | CYN: | | CYH: | | CYJ: | | AMR: | | CGC: | | CAN: | | CSN: | | DSL: | | HAO: | | GLP: | | CMP: | | CYU: | | TER: | | GEI: | | OAC: | | ONI: | | PSEU: | | CEP: | | MIC: | | ARP: | | GVI: | | ANA: | | NPU: | | NOS: | | NOP: | | AVA: | | ANB: | | ACY: | | NAZ: | | CSG: | | CALO: | | CALT: | | RIV: | | PMA: | | PMM: | | PMT: | | PMN: | | PMI: | | PMB: | | PMC: | | PMF: | | PMG: | | PMH: | | PMJ: | | PME: | | CTHE: | | PLP: | | SCS: | | BFR: | | BFS: | | BFG: | | BVU: | | BHL: | | PGI: | | PGN: | | PGT: | | PAH: | | PDI: | | PPN: | | OSP: | | TFO: | | PRU: | | DOI: | | CPI: | | FCO: | | CTE: | | CPC: | | PAA: | | CTS: | | RRS: | | RCA: | | CAU: | | CAG: | | CHL: | | CAP: | | DGE: | | DDR: | | DMR: | | DGO: | | DPD: | | TTH: | | TTJ: | | TTS: | | TTL: | | TOS: | | TME: | | TAF: | | DIN: | | DDF: | | DAP: | | CNI: | | NDE: | | LFC: | | LFI: | | TID: | | MJA: | | MFE: | | MVU: | | MFS: | | MIF: | | MIG: | | MMP: | | MMQ: | | MMX: | | MMZ: | | MMD: | | MAE: | | MVN: | | MVO: | | MOK: | | MAC: | | MBA: | | MMA: | | MMAZ: | | MBU: | | MMH: | | MEV: | | MZH: | | MPY: | | MHZ: | | MTP: | | MCJ: | | MHI: | | MHU: | | MLA: | | MEM: | | MBG: | | MPI: | | MBN: | | MFO: | | MPL: | | MEZ: | | MER: | | MTH: | | MMG: | | MST: | | MSI: | | MRU: | | MEB: | | MEL: | | MEW: | | METH: | | MFV: | | MKA: | | MAX: | | AFU: | | AVE: | | AST: | | FPL: | | TAC: | | TVO: | | PTO: | | FAC: | | TAR: | | SSO: | | SOL: | | STO: | | SAI: | | SACN: | | SACR: | | SACS: | | SIS: | | SIA: | | SIM: | | SID: | | SIY: | | SIN: | | SII: | | SIH: | | SIR: | | SIC: | | MSE: | | MCN: | | AHO: | | PAI: | | PCL: | | POG: | | TNE: | | TTN: | | VDI: | | NMR: | | NIR: | | NKR: | | CSY: | | NGA: | |
» show all
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| Reference |
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| Authors |
Roper JM, Raux E, Brindley AA, Schubert HL, Gharbia SE, Shah HN, Warren MJ |
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| Title |
The enigma of cobalamin (Vitamin B12) biosynthesis in Porphyromonas gingivalis. Identification and characterization of a functional corrin pathway. |
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| Journal |
J. Biol. Chem. 275 (2000) 40316-23. |
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| Organism |
Porphyromonas gingivalis |
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| Reference |
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| Authors |
Roessner CA, Williams HJ, Scott AI |
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| Title |
Genetically engineered production of 1-desmethylcobyrinic acid, 1-desmethylcobyrinic acid a,c-diamide, and cobyrinic acid a,c-diamide in Escherichia coli implies a role for CbiD in C-1 methylation in the anaerobic pathway to cobalamin. |
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| Journal |
J. Biol. Chem. 280 (2005) 16748-53. |
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| Organism |
Salmonella enterica |
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| Reference |
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| Authors |
Moore SJ, Lawrence AD, Biedendieck R, Deery E, Frank S, Howard MJ, Rigby SE, Warren MJ |
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| Title |
Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12). |
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| Journal |
Proc. Natl. Acad. Sci. U. S. A. 110 (2013) 14906-11. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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