| Entry |
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| Name |
tRNA (cytosine34-C5)-methyltransferase;
hTrm4 Mtase;
hTrm4 methyltransferase;
hTrm4 (gene name);
tRNA:m5C-methyltransferase (ambiguous)
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:tRNA (cytosine34-C5)-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + cytosine34 in tRNA precursor = S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor [RN: R00595]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
cytosine34 in tRNA precursor
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
5-methylcytosine34 in tRNA precursor
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| Comment |
The human enzyme is specific for C5-methylation of cytosine34 in tRNA precursors. The intron in the human pre-tRNALeu(CAA) is indispensable for the C5-methylation of cytosine in the first position of the anticodon. It is not able to form 5-methylcytosine at positions 48 and 49 of human and yeast tRNA precursors [1].
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| Orthology |
| tRNA (cytosine34-C5)-methyltransferase |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MCF: | | MMU: | | RNO: | | CGE: | | HGL: | | CFA: | | AML: | | FCA: | | BTA: | | BOM: | | PHD: | | CHX: | | SSC: | | ECB: | | MYB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | FAB: | | PHI: | | APLA: | | FPG: | | FCH: | | CLV: | | ASN: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | MZE: | | OLA: | | XMA: | | LCM: | | BFO: | | CIN: | | SPU: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | AAG: | | CQU: | | AME: | | NVI: | | TCA: | | BMOR: | | API: | | PHU: | | ISC: | | CEL: | | CBR: | | LOA: | | TSP: | | SMM: | | NVE: | | HMG: | | TAD: | | AQU: | | SBI: | | CRE: | | OLU: | | OTA: | | MIS: | | MPP: | | CSL: | | CME: | | GSL: | | ECU: | | EIN: | | EHE: | | NCE: | | MBR: | | DDI: | | DPP: | | DFA: | | ACAN: | | PBE: | | TAN: | | BBO: | | BEQ: | | CPV: | | TGO: | | TET: | | PTI: | | TPS: | | PIF: | | EHX: | | GTT: | | TCR: | | LMA: | | LIF: | | LDO: | | LMI: | | LBZ: | | NGR: | | TVA: | | GLA: | |
» show all
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| Reference |
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| Authors |
Brzezicha B, Schmidt M, Makalowska I, Jarmolowski A, Pienkowska J, Szweykowska-Kulinska Z |
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| Title |
Identification of human tRNA:m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the pre-tRNA Leu (CAA). |
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| Journal |
Nucleic. Acids. Res. 34 (2006) 6034-43. |
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| Organism |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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