KEGG   ENZYME: 2.1.1.204Help
Entry
EC 2.1.1.204                Enzyme                                 

Name
tRNA (cytosine38-C5)-methyltransferase;
hDNMT2 (gene name);
DNMT2 (gene name);
TRDMT1 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:tRNA (cytosine38-C5)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + cytosine38 in tRNA = S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA [RN:R00595]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
cytosine38 in tRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
5-methylcytosine38 in tRNA
Comment
The eukaryotic enzyme catalyses methylation of cytosine38 in the anti-codon loop of tRNAAsp(GTC), tRNAVal(AAC) and tRNAGly(GCC). Methylation by Dnmt2 protects tRNAs against stress-induced cleavage by ribonuclease [3].
History
EC 2.1.1.204 created 1976 as EC 2.1.1.29, part transferred 2011 to EC 2.1.1.204
Orthology
K15336  tRNA (cytosine38-C5)-methyltransferase
Genes
HSA: 1787(TRDMT1)
PTR: 738954(TRDMT1)
PPS: 100994021(TRDMT1)
GGO: 101139244(TRDMT1)
PON: 100444503(TRDMT1)
NLE: 100605724(TRDMT1)
MCC: 699758(TRDMT1)
MCF: 102122839(TRDMT1)
CSAB: 103237951(TRDMT1)
RRO: 104655337(TRDMT1)
RBB: 108527744(TRDMT1)
CJC: 100407322(TRDMT1)
SBQ: 101045369(TRDMT1)
MMU: 13434(Trdmt1)
RNO: 291324(Trdmt1)
CGE: 100773025(Trdmt1)
NGI: 103734824(Trdmt1)
HGL: 101719891(Trdmt1)
CCAN: 109700440(Trdmt1)
OCU: 100346643(TRDMT1)
TUP: 102491382(TRDMT1)
CFA: 487116(TRDMT1)
AML: 100463906(TRDMT1)
UMR: 103664205(TRDMT1)
ORO: 101381218(TRDMT1)
FCA: 101091708(TRDMT1)
PTG: 102964129(TRDMT1)
AJU: 106979876(TRDMT1)
BTA: 353353(TRDMT1)
BOM: 102282714(TRDMT1)
BIU: 109567981(TRDMT1)
PHD: 102323107
CHX: 102180682(TRDMT1)
OAS: 101110692(TRDMT1)
SSC: 100302362(TRDMT1)
CFR: 102512226(TRDMT1)
CDK: 105099236(TRDMT1)
BACU: 103017247
LVE: 103089631
OOR: 101283176(TRDMT1)
ECB: 100068465(TRDMT1)
EPZ: 103544036(TRDMT1)
EAI: 106834425(TRDMT1)
MYB: 102242384(TRDMT1)
MYD: 102768922(TRDMT1)
HAI: 109393562(TRDMT1)
RSS: 109454902(TRDMT1)
PALE: 102879724(TRDMT1)
LAV: 100674519(TRDMT1)
TMU: 101351605
MDO: 100026881(TRDMT1)
SHR: 100933240(TRDMT1)
OAA: 100091400
GGA: 420520(TRDMT1)
MGP: 100547420(TRDMT1)
CJO: 107309025(TRDMT1)
APLA: 101794189(TRDMT1)
ACYG: 106030352(TRDMT1)
TGU: 100230580(TRDMT1)
GFR: 102032424(TRDMT1)
FAB: 101814992(TRDMT1)
PHI: 102108198(TRDMT1)
PMAJ: 107200477(TRDMT1)
CCW: 104689209(TRDMT1)
FPG: 101918245(TRDMT1)
FCH: 102059325(TRDMT1)
CLV: 102087351(TRDMT1)
EGZ: 104135615(TRDMT1)
AAM: 106483601(TRDMT1)
ASN: 102376738(TRDMT1)
AMJ: 102565207(TRDMT1)
PSS: 102443485(TRDMT1)
CMY: 102942823(TRDMT1)
CPIC: 101948080(TRDMT1)
ACS: 100562684(trdmt1)
PVT: 110085994(TRDMT1)
PBI: 103065020(TRDMT1)
GJA: 107120970(TRDMT1)
XLA: 379360(trdmt1.L)
XTR: 448379(trdmt1)
NPR: 108793079(TRDMT1)
DRE: 449878(trdmt1)
SANH: 107657754(trdmt1) 107677147
IPU: 108271445(trdmt1)
AMEX: 103043215(trdmt1)
LCO: 104939607(trdmt1)
MZE: 101477362(trdmt1)
OLA: 101155097(trdmt1)
XMA: 102227471(trdmt1)
PRET: 103482231(trdmt1)
NFU: 107382625(trdmt1)
CSEM: 103376850(trdmt1)
HCQ: 109519514(trdmt1)
BPEC: 110174636(trdmt1)
SASA: 106578517(trdmt1)
ELS: 105027107(trdmt1)
SFM: 108918892(trdmt1)
LCM: 102356211(TRDMT1)
CMK: 103181574(trdmt1)
CIN: 100183289
SPU: 764431
SKO: 102802258
DME: Dmel_CG10692(Mt2)
DPO: Dpse_GA10499(Dpse_Mt2)
DSI: Dsimw501_GD23816(Dsim_Mt2)
MDE: 101899369
AAG: 5567564
AME: 410512(Dnmt2)
BIM: 100741608
BTER: 100651101
SOC: 105195023
AEC: 105154851
ACEP: 105620783
PBAR: 105429247
HST: 105180694
CFO: 105256853
LHU: 105676696
PGC: 109862018
NVI: 100117910
TCA: 663081(Dnmt2)
DPA: 109538977
NVL: 108566736
BMOR: 692480(Dnmt2)
PMAC: 106718334
PRAP: 111003452
API: 100167127
DNX: 107164163
ZNE: 110837652
FCD: 110844434
DPX: DAPPUDRAFT_187425(DNMT2)
TSP: Tsp_05801
CRG: 105344617
MYI: 110459962
OBI: 106871816
SHX: MS3_03852
EPA: 110254156
HMG: 100206481
AQU: 100638692
ATH: AT5G25480(DNMT2)
ALY: ARALYDRAFT_489406(DNMT2)
CRB: 17883675
BRP: 103874407
BOE: 106303640
THJ: 104799221
CPAP: 110811345
CIT: 102609884
TCC: 18588980
GRA: 105792840
GHI: 107907768
DZI: 111303368
EGR: 104437064
VRA: 106775135
VAR: 108341182
CCAJ: 109803623
CAM: 101491158
AIP: 107623462
LJA: Lj6g3v2204760.1(Lj6g3v2204760.1)
LANG: 109333630
FVE: 101293747
PPER: 18789470
PMUM: 103320079
PAVI: 110769100
ZJU: 107421223
CSV: 101219472
CMO: 103488282
MCHA: 111005184
CMAX: 111491952
CMOS: 111462432
CPEP: 111805612
RCU: 8278568
JCU: 105637669
POP: 7495763
JRE: 109001811
SLY: 101263628
SPEN: 107029004
SOT: 102596409
CANN: 107839049
NSY: 104233117
NTO: 104108135
INI: 109174645
SIND: 105166670
OEU: 111383863
HAN: 110898533
LSV: 111883157
DCR: 108206371
BVG: 104887679
SOE: 110776057
NNU: 104595329
OSA: 9268926
DOSA: Os01t0612000-01(Os01g0612000)
OBR: 102707736
BDI: 100822436
ATS: 109746509(LOC109746509)
SBI: 8054375
ZMA: 542067(met4)
SITA: 101758674
PDA: 103721236
EGU: 105047774
MUS: 103994888
DCT: 110115622
AOF: 109820601
ATR: 18431727
PPP: 112289487
OLU: OSTLU_16070(DMT3502) OSTLU_87597(DMT3501)
APRO: F751_1528
SPO: SPBC19C2.02(pmt1)
ABP: AGABI1DRAFT123710(AGABI1DRAFT_123710)
ABV: AGABI2DRAFT198459(AGABI2DRAFT_198459)
DDI: DDB_G0288047(dnmA)
DFA: DFA_08535(dnmA)
EHI: EHI_069140(32.t00050)
CPV: cgd5_2100
SMIN: v1.2.011495.t1(symbB.v1.2.011495.t1) v1.2.012243.t1(symbB.v1.2.012243.t1) v1.2.025625.t1(symbB.v1.2.025625.t1) v1.2.030523.t1(symbB.v1.2.030523.t1)
PIR: VN12_08925(hpaIIM)
 » show all
Taxonomy
Reference
1  [PMID:16424344]
  Authors
Goll MG, Kirpekar F, Maggert KA, Yoder JA, Hsieh CL, Zhang X, Golic KG, Jacobsen SE, Bestor TH
  Title
Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2.
  Journal
Science. 311 (2006) 395-8.
  Sequence
[hsa:1787]
Reference
2  [PMID:18567810]
  Authors
Jurkowski TP, Meusburger M, Phalke S, Helm M, Nellen W, Reuter G, Jeltsch A
  Title
Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism.
  Journal
RNA. 14 (2008) 1663-70.
Reference
3  [PMID:20679393]
  Authors
Schaefer M, Pollex T, Hanna K, Tuorto F, Meusburger M, Helm M, Lyko F
  Title
RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage.
  Journal
Genes. Dev. 24 (2010) 1590-5.
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.204
IUBMB Enzyme Nomenclature: 2.1.1.204
ExPASy - ENZYME nomenclature database: 2.1.1.204
BRENDA, the Enzyme Database: 2.1.1.204

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