KEGG   ENZYME: 2.1.1.204Help
Entry
EC 2.1.1.204                Enzyme                                 

Name
tRNA (cytosine38-C5)-methyltransferase;
hDNMT2 (gene name);
DNMT2 (gene name);
TRDMT1 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:tRNA (cytosine38-C5)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + cytosine38 in tRNA = S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA [RN:R00595]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
cytosine38 in tRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
5-methylcytosine38 in tRNA
Comment
The eukaryotic enzyme catalyses methylation of cytosine38 in the anti-codon loop of tRNAAsp(GTC), tRNAVal(AAC) and tRNAGly(GCC). Methylation by Dnmt2 protects tRNAs against stress-induced cleavage by ribonuclease [3].
History
EC 2.1.1.204 created 1976 as EC 2.1.1.29, part transferred 2011 to EC 2.1.1.204
Orthology
K15336  
tRNA (cytosine38-C5)-methyltransferase
Genes
HSA: 
1787(TRDMT1)
PTR: 
738954(TRDMT1)
PPS: 
100994021(TRDMT1)
GGO: 
101139244(TRDMT1)
PON: 
NLE: 
100605724(TRDMT1)
MCF: 
102122839(TRDMT1)
CJC: 
100407322(TRDMT1)
MMU: 
13434(Trdmt1)
RNO: 
291324(Trdmt1)
CGE: 
100773025(Trdmt1)
NGI: 
103734824(Trdmt1)
HGL: 
101719891(Trdmt1)
OCU: 
100346643(TRDMT1)
TUP: 
102491382(TRDMT1)
CFA: 
487116(TRDMT1)
AML: 
100463906(TRDMT1)
UMR: 
103664205(TRDMT1)
FCA: 
101091708(TRDMT1)
PTG: 
102964129(TRDMT1)
BTA: 
353353(TRDMT1)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
100302362(TRDMT1)
CFR: 
BACU: 
LVE: 
ECB: 
100068465(TRDMT1)
MYB: 
102242384(TRDMT1)
MYD: 
102768922(TRDMT1)
PALE: 
102879724(TRDMT1)
MDO: 
100026881(TRDMT1)
SHR: 
OAA: 
GGA: 
420520(TRDMT1)
MGP: 
APLA: 
101794189(TRDMT1)
TGU: 
100230580(TRDMT1)
FAB: 
101814992(TRDMT1)
PHI: 
102108198(TRDMT1)
FPG: 
101918245(TRDMT1)
FCH: 
102059325(TRDMT1)
CLV: 
102087351(TRDMT1)
ASN: 
102376738(TRDMT1)
AMJ: 
102565207(TRDMT1)
PSS: 
102443485(TRDMT1)
CMY: 
102942823(TRDMT1)
ACS: 
100562684(trdmt1)
PBI: 
103065020(TRDMT1)
XLA: 
379360(trdmt1)
XTR: 
448379(trdmt1)
DRE: 
449878(trdmt1)
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103181574(trdmt1)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
Dpse_GA10499(Dpse_Mt2)
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
410512(Dnmt2)
NVI: 
TCA: 
663081(Dnmt2)
BMOR: 
692480(Dnmt2)
API: 
PHU: 
ISC: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
AT5G25480(DNMT2)
ALY: 
CRB: 
EUS: 
BRP: 
CIT: 
CIC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
POP: 
POPTR_0006s26700g(POPTRDRAFT_416746)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os01t0612000-01(Os01g0612000)
OBR: 
BDI: 
SBI: 
SORBI_03g027700(SORBIDRAFT_03g027700)
ZMA: 
542067(met4)
SITA: 
PDA: 
MUS: 
ATR: 
s00042p00136580(AMTR_s00042p00136580)
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OSTLU_16070(DMT3502) OSTLU_87597(DMT3501)
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
SPO: 
DSQ: 
PCO: 
SHS: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT123710(AGABI1DRAFT_123710)
ABV: 
AGABI2DRAFT198459(AGABI2DRAFT_198459)
CPUT: 
SLA: 
MBR: 
DDI: 
DPP: 
DFA: 
DFA_08535(dnmA)
EHI: 
EHI_069140(32.t00050)
EDI: 
ACAN: 
CPV: 
TGO: 
PTI: 
TPS: 
EHX: 
GTT: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:16424344]
  Authors
Goll MG, Kirpekar F, Maggert KA, Yoder JA, Hsieh CL, Zhang X, Golic KG, Jacobsen SE, Bestor TH
  Title
Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2.
  Journal
Science. 311 (2006) 395-8.
  Sequence
[hsa:1787]
Reference
2  [PMID:18567810]
  Authors
Jurkowski TP, Meusburger M, Phalke S, Helm M, Nellen W, Reuter G, Jeltsch A
  Title
Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism.
  Journal
RNA. 14 (2008) 1663-70.
Reference
3  [PMID:20679393]
  Authors
Schaefer M, Pollex T, Hanna K, Tuorto F, Meusburger M, Helm M, Lyko F
  Title
RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage.
  Journal
Genes. Dev. 24 (2010) 1590-5.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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