KEGG   ENZYME: 2.1.1.208Help
Entry
EC 2.1.1.208                Enzyme                                 

Name
23S rRNA (uridine2479-2'-O)-methyltransferase;
AviRb
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:23S rRNA (uridine2479-2'-O)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + uridine2479 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methyluridine2479 in 23S rRNA
Substrate
S-adenosyl-L-methionine [CPD:C00019];
uridine2479 in 23S rRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
2'-O-methyluridine2479 in 23S rRNA
Comment
Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis. To protect itself from the antibiotic, Streptomyces viridochromogenes utilizes two methyltransferases, 23S rRNA (uridine2479-2'-O)-methyltransferase and EC 2.1.1.209 [23S rRNA (guanine2535-N1)-methyltransferase], whose actions confer avilamycin resistance to the RNA.
History
EC 2.1.1.208 created 2011
Reference
1  [PMID:15581897]
  Authors
Mosbacher TG, Bechthold A, Schulz GE
  Title
Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes.
  Journal
J. Mol. Biol. 345 (2005) 535-45.
  Sequence
Reference
2  [PMID:12828631]
  Authors
Treede I, Jakobsen L, Kirpekar F, Vester B, Weitnauer G, Bechthold A, Douthwaite S
  Title
The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the  guanosine 2535 base and the uridine 2479 ribose.
  Journal
Mol. Microbiol. 49 (2003) 309-18.
  Sequence
Reference
3  [PMID:11181344]
  Authors
Weitnauer G, Gaisser S, Trefzer A, Stockert S, Westrich L, Quiros LM, Mendez C, Salas JA, Bechthold A
  Title
An ATP-binding cassette transporter and two rRNA methyltransferases are involved  in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tu57.
  Journal
Antimicrob. Agents. Chemother. 45 (2001) 690-5.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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