KEGG ENZYME: 2.1.1.214

ENZYME: 2.1.1.214

Entry

EC 2.1.1.214 Enzyme

Name

tRNA (guanine10-N2)-methyltransferase;
(m2G10) methyltransferase;
Trm11-Trm112 complex

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:tRNA (guanine10-N2)-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + guanine10 in tRNA = S-adenosyl-L-homocysteine + N2-methylguanine10 in tRNA

Substrate

S-adenosyl-L-methionine [CPD:C00019];
guanine10 in tRNA

Product

S-adenosyl-L-homocysteine [CPD:C00021];
N2-methylguanine10 in tRNA

Comment

In contrast to the archaeal enzyme tRNA (guanine10-N2)-dimethyltransferase (EC 2.1.1.213), tRNA (guanine10-N2)-methyltransferase from yeast does not catalyse the methylation from N2-methylguanine10 to N2-dimethylguanine10 in tRNA.

Orthology

K15430

tRNA (guanine10-N2)-methyltransferase

Genes

HSA:	60487(TRMT11)
PTR:	745151(TRMT11)
PPS:	100987629(TRMT11)
GGO:	101128114(TRMT11)
PON:	100174524(TRMT11)
MCC:	712712(TRMT11)
MMU:	73681(Trmt11)
RNO:	378794(Trmt11)
CFA:	476285(TRMT11)
AML:	100468309
FCA:	101084627(TRMT11)
BTA:	514867(TRMT11)
SSC:	100152782(TRMT11)
ECB:	100073022(TRMT11)
MDO:	100030752
SHR:	100921700(TRMT11)
OAA:	100075188
GGA:	378793(TRMT11)
MGP:	100547621
TGU:	100221498(TRMT11)
ACS:	100566530
XLA:	432012(trmt11)
XTR:	100497209
DRE:	393185(trmt11)
TRU:	445946
OLA:	101166247
BFO:	BRAFLDRAFT_204971
CIN:	100177819
SPU:	576775
DME:	Dmel_CG1074
DPO:	Dpse_GA10534
DAN:	Dana_GF18217
DER:	Dere_GG12428
DPE:	Dper_GL21470
DSE:	Dsec_GM10758
DSI:	Dsim_GD19733
DWI:	Dwil_GK13537
DYA:	Dyak_GE25419
DGR:	Dgri_GH11743
DMO:	Dmoj_GI10687
DVI:	Dvir_GJ10432
AGA:	AgaP_AGAP002384
AAG:	AaeL_AAEL003922
CQU:	CpipJ_CPIJ005930
AME:	724798
NVI:	100115843(NV15795)
TCA:	663262
API:	100164143
PHU:	Phum_PHUM529310
ISC:	IscW_ISCW007305
CEL:	CELE_Y71F9AL.1(Y71F9AL.1)
CBR:	CBG04220
SMM:	Smp_077670
NVE:	NEMVE_v1g161519
TAD:	TRIADDRAFT_27498
AQU:	100634188
ATH:	AT3G26410
ALY:	ARALYDRAFT_484403
GMX:	100790476 100814705
CSV:	101207825 101209327 101226784
RCU:	RCOM_0380820
POP:	POPTR_829545
VVI:	100255656
OSA:	4329664
DOSA:	Os02t0556400-01(Os02g0556400)
BDI:	100840754
SBI:	SORBI_04g022710(SORBIDRAFT_04g022710)
ZMA:	100280406
SMO:	SELMODRAFT_108775 SELMODRAFT_93468
PPP:	PHYPADRAFT_107226
CRE:	CHLREDRAFT_108207
VCN:	VOLCADRAFT_62647
OLU:	OSTLU_37849
OTA:	Ot17g01660
CME:	CMO333C
SCE:	YOL124C(TRM11)
AGO:	AGOS_ADL161C
ERC:	Ecym_2049
KLA:	KLLA0C12903g
LTH:	KLTH0F18788g
PPA:	PAS_chr1-4_0354
VPO:	Kpol_1076p1
ZRO:	ZYRO0C02596g
CGR:	CAGL0E01925g
NCS:	NCAS_0C04590(NCAS0C04590)
NDI:	NDAI_0G03960(NDAI0G03960)
TPF:	TPHA_0P01320(TPHA0P01320)
TBL:	TBLA_0B08600(TBLA0B08600)
TDL:	TDEL_0E00590(TDEL0E00590)
KAF:	KAFR_0C01690(KAFR0C01690)
DHA:	DEHA2F16676g
PIC:	PICST_50882
PGU:	PGUG_04212
LEL:	LELG_02872
CAL:	CaO19.13408 CaO19.5987
CTP:	CTRG_02524
CDU:	CD36_85110
COT:	CORT_0C04780
YLI:	YALI0C13882g
CLU:	CLUG_04545
NCR:	NCU04407
SMP:	SMAC_07340
PAN:	PODANSg7452
TTT:	THITE_2114858
MTM:	MYCTH_2298473
MGR:	MGG_06857
NHE:	NECHADRAFT_94203
VAL:	VDBG_01417
SSL:	SS1G_06746
BFU:	BC1G_03294
ANI:	AN3647.2
NFI:	NFIA_104120
AFM:	AFUA_4G12140
AOR:	AOR_1_1774154(AO090003000995)
ANG:	ANI_1_2722014(An01g07400)
AFV:	AFLA_028210
ACT:	ACLA_051140
PCS:	Pc22g05270
CIM:	CIMG_01643
CPW:	CPC735_048330
PBL:	PAAG_02786
URE:	UREG_05369
ABE:	ARB_00432
TVE:	TRV_02688
AJE:	HCAG_01480
PNO:	SNOG_06921
PTE:	PTT_15965
TML:	GSTUM_00003275001
SPO:	SPBC16D10.02(trm11)
CNE:	CNK00740
CNB:	CNBK2760
CGI:	CGB_K3560C
LBC:	LACBIDRAFT_189099
CCI:	CC1G_04487
SCM:	SCHCODRAFT_57351
UMA:	UM02155.1
MGL:	MGL_2029
PGR:	PGTG_01428
MBR:	MONBRDRAFT_38107
NGR:	NAEGRDRAFT_30617
DDI:	DDB_G0283969(trmt11)
DPP:	DICPUDRAFT_51090
EHI:	EHI_023130(25.t00002)
EDI:	EDI_247510
PFA:	PF13_0236
PFD:	PFDG_04278
PFH:	PFHG_02131
PYO:	PY05490
PCB:	PC000313.00.0
PBE:	PB000339.00.0
PKN:	PKH_121130
PVX:	PVX_083055
PCY:	PCYB_122050
TAN:	TA03045
TPV:	TP01_0635
BBO:	BBOV_IV002880(21.m02958)
CPV:	cgd5_4420
CHO:	Chro.50400
TGO:	TGME49_077860
TET:	TTHERM_00051970
PTM:	GSPATT00037889001
TCR:	509885.60
LMA:	LMJF_05_1010
LIF:	LINJ_05_1010
LDO:	LDBPK_051010
LMI:	LMXM_05_1010
LBZ:	LBRM_05_1010
GLA:	GL50803_13525
TVA:	TVAG_299110
PTI:	PHATRDRAFT_45681
TPS:	THAPSDRAFT_22467
PIF:	PITG_16940

» show all

Reference

1 [PMID:15899842]

Authors

Purushothaman SK, Bujnicki JM, Grosjean H, Lapeyre B

Title

Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA.

Journal

Mol. Cell. Biol. 25 (2005) 4359-70.

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.214

IUBMB Enzyme Nomenclature:

2.1.1.214

ExPASy - ENZYME nomenclature database:

2.1.1.214

BRENDA, the Enzyme Database:

2.1.1.214

All links

Ontology (2)   
   KEGG BRITE (2)   
Chemical substance (2)   
   KEGG COMPOUND (2)   
Chemical reaction (2)   
   KEGG ENZYME (2)   
Gene (373)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (177)   
   KEGG DGENES (18)   
   KEGG EGENES (119)   
   KEGG MGENES (58)   
Protein sequence (3)   
   UniProt (3)   
Protein domain (1)   
   PROSITE(DOC) (1)   
Literature (1)   
   PubMed (1)   
Enzyme (4)   
   BRENDA (1)   
   EXPASY-ENZYME (1)   
   EXPLORENZ (1)   
   IUBMB (1)   
All databases (388)   

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