KEGG   ENZYME: 2.1.1.218Help
Entry
EC 2.1.1.218                Enzyme                                 

Name
tRNA (adenine9-N1)-methyltransferase;
Trm10p (ambiguous);
tRNA(m1G9/m1A9)-methyltransferase;
tRNA(m1G9/m1A9)MTase;
TK0422p (gene name);
tRNA m1A9-methyltransferase;
tRNA m1A9 Mtase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:tRNA (adenine9-N1)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + adenine9 in tRNA = S-adenosyl-L-homocysteine + N1-methyladenine9 in tRNA
Substrate
S-adenosyl-L-methionine [CPD:C00019];
adenine9 in tRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N1-methyladenine9 in tRNA
Comment
The enzyme from Sulfolobus acidocaldarius specifically methylates adenine9 in tRNA [1]. The bifunctional enzyme from Thermococcus kodakaraensis also catalyses the methylation of guanine9 in tRNA (cf. EC 2.1.1.221, tRNA (guanine9-N1)-methyltransferase).
History
EC 2.1.1.218 created 2011 (EC 2.1.1.36 created 1972, part transferred 2011 to EC 2.1.1.218)
Orthology
K15566  
tRNA (adenine9-N1/guanine9-N1)-methyltransferase
Genes
TAM: 
DTE: 
MKA: 
AFU: 
AFG: 
APO: 
AVE: 
AST: 
FPL: 
GAC: 
GAH: 
PHO: 
PH0711(PH0711)
PAB: 
PFU: 
PFI: 
PYN: 
PYA: 
PYS: 
TKO: 
TON: 
TGA: 
TSI: 
TBA: 
THE: 
THA: 
THM: 
TLT: 
THS: 
TNU: 
TEU: 
TGY: 
THV: 
PPAC: 
APE: 
ACJ: 
IHO: 
IIS: 
IAG: 
HBU: 
PFM: 
PDL: 
SSO: 
SOL: 
SSOA: 
SSOL: 
SSOF: 
STO: 
SAI: 
SACN: 
SACR: 
SACS: 
SIS: 
SIA: 
SIM: 
SID: 
SIY: 
SIN: 
SII: 
SIH: 
SIR: 
SIC: 
MSE: 
MCN: 
AHO: 
PAI: 
PIS: 
PCL: 
PAS: 
PYR: 
POG: 
TNE: 
PYW: 
CMA: 
TUZ: 
TTN: 
VDI: 
VMO: 
ASC: 
CLG: 
NEQ: 
NAA: 
 » show all
Taxonomy
Reference
1  [PMID:20525789]
  Authors
Kempenaers M, Roovers M, Oudjama Y, Tkaczuk KL, Bujnicki JM, Droogmans L
  Title
New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA.
  Journal
Nucleic. Acids. Res. 38 (2010) 6533-43.
  Sequence
[sai:Saci_1677] [tko:TK0422]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system