| Entry |
|
|---|
| Name |
tRNA (adenine57-N1/adenine58-N1)-methyltransferase;
TrmI;
PabTrmI;
AqTrmI;
MtTrmI
|
|---|
| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
 |
|---|
| Sysname |
S-adenosyl-L-methionine:tRNA (adenine57/adenine58-N1)-methyltransferase
|
|---|
| Reaction(IUBMB) |
2 S-adenosyl-L-methionine + adenine57/adenine58 in tRNA = 2 S-adenosyl-L-homocysteine + N1-methyladenine57/N1-methyladenine58 in tRNA
|
|---|
| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
adenine57/adenine58 in tRNA
|
|---|
| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
N1-methyladenine57/N1-methyladenine58 in tRNA
|
|---|
| Comment |
The enzyme catalyses the formation of N1-methyladenine at two adjacent positions (57 and 58) in the T-loop of certain tRNAs (e.g. tRNAAsp). Methyladenosine at position 57 is an obligatory intermediate for the synthesis of methylinosine, which is commonly found at position 57 of archaeal tRNAs.
|
|---|
| Orthology |
| tRNA (adenine57-N1/adenine58-N1)-methyltransferase |
|
|---|
| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | AAG: | | CQU: | | AME: | | NVI: | | TCA: | | API: | | PHU: | | ISC: | | CEL: | | CBR: | | BMY: | | TSP: | | SMM: | | NVE: | | HMG: | | TAD: | | AQU: | | ATH: | | ALY: | | GMX: | | MTR: | | CSV: | | RCU: | | POP: | | VVI: | | OSA: | | DOSA: | | BDI: | | SBI: | | ZMA: | | SMO: | | PPP: | | CRE: | | VCN: | | OLU: | | OTA: | | CME: | | SCE: | | AGO: | | ERC: | | KLA: | | LTH: | | PPA: | | VPO: | | ZRO: | | CGR: | | NCS: | | NDI: | | TPF: | | TBL: | | TDL: | | KAF: | | DHA: | | PIC: | | PGU: | | LEL: | | CAL: | | CTP: | | CDU: | | COT: | | YLI: | | CLU: | | NCR: | | SMP: | | PAN: | | TTT: | | MTM: | | MGR: | | FGR: | | NHE: | | VAL: | | SSL: | | BFU: | | ANI: | | NFI: | | AFM: | | AOR: | | ANG: | | AFV: | | ACT: | | PCS: | | CIM: | | CPW: | | PBL: | | URE: | | ABE: | | TVE: | | AJE: | | PNO: | | PTE: | | ZTR: | | TML: | | SPO: | | CNE: | | CNB: | | CGI: | | PPL: | | CCI: | | UMA: | | MGL: | | PGR: | | NGR: | | DDI: | | DPP: | | EHI: | | EDI: | | PFA: | | PFD: | | PFH: | | PYO: | | PCB: | | PBE: | | PKN: | | PVX: | | PCY: | | TAN: | | TPV: | | BBO: | | CPV: | | CHO: | | TGO: | | TET: | | PTM: | | TBR: | | TCR: | | LIF: | | LDO: | | LMI: | | LBZ: | | GLA: | | PTI: | | TPS: | | PIF: | | DVU: | | DVL: | | DVM: | | DVG: | | DDE: | | DDS: | | DDN: | | DMA: | | DSA: | | DAS: | | DAF: | | DHY: | | DPI: | | LIP: | | LIR: | | DBA: | | DRT: | | SFU: | | DBR: | | HMR: | | DKU: | | DAU: | | TMR: | | TTE: | | TEX: | | THX: | | TPD: | | TIT: | | TMT: | | TBO: | | TWI: | | ADG: | | CSC: | | ATE: | | COB: | | CHD: | | COW: | | CKI: | | CKN: | | CLC: | | TOC: | | TNR: | | NTH: | | HOR: | | MTU: | | MTV: | | MTC: | | MRA: | | MTF: | | MTB: | | MTK: | | MTZ: | | MTG: | | MTI: | | MTE: | | MTL: | | MTO: | | MTD: | | MTN: | | MTJ: | | MTUB: | | MBO: | | MBB: | | MBT: | | MBM: | | MBK: | | MAF: | | MCE: | | MCQ: | | MCV: | | MCX: | | MCZ: | | MLE: | | MLB: | | MPA: | | MAV: | | MIT: | | MIR: | | MIA: | | MID: | | MSM: | | MSG: | | MSA: | | MUL: | | MVA: | | MGI: | | MSP: | | MAB: | | MMV: | | MMC: | | MKM: | | MJL: | | MJD: | | MMI: | | MRH: | | MMM: | | MCB: | | MLI: | | ASD: | | CGL: | | CGB: | | CGU: | | CGT: | | CEF: | | CDI: | | CDP: | | CDH: | | CDT: | | CDE: | | CDR: | | CDA: | | CDZ: | | CDB: | | CDS: | | CDD: | | CDW: | | CDV: | | CJK: | | CUR: | | CUA: | | CAR: | | CKP: | | CPU: | | CPL: | | CPG: | | CPP: | | CPK: | | CPQ: | | CPX: | | CPZ: | | COR: | | COP: | | COD: | | COS: | | COI: | | COE: | | COU: | | CRD: | | CUL: | | CUC: | | CUE: | | CVA: | | CHN: | | CCN: | | NFA: | | NCY: | | NBR: | | RHA: | | RER: | | ROP: | | REQ: | | GBR: | | GPO: | | GOR: | | TPR: | | SRT: | | SCO: | | SMA: | | SGR: | | SCB: | | SSX: | | SVL: | | SCT: | | SCY: | | SFA: | | SBH: | | SHY: | | SHO: | | SVE: | | SDV: | | SALB: | | STRP: | | SFI: | | KSK: | | TWH: | | TWS: | | LXX: | | CMI: | | CMS: | | CMC: | | MTS: | | ART: | | AAU: | | ACH: | | AAI: | | APN: | | ARR: | | RSA: | | KRH: | | MLU: | | RMU: | | RDN: | | BCV: | | BFA: | | JDE: | | KSE: | | XCE: | | IVA: | | SKE: | | CFL: | | CFI: | | CGA: | | ICA: | | PAC: | | PAK: | | PAV: | | PAX: | | PAZ: | | PAW: | | PAD: | | PCN: | | PACC: | | PACH: | | PFR: | | PPC: | | PBO: | | PRA: | | MPH: | | NCA: | | KFL: | | TFU: | | NDA: | | NAL: | | TCU: | | SRO: | | FRA: | | FRE: | | FRI: | | FAL: | | FSY: | | ACE: | | GOB: | | BSD: | | MMAR: | | KRA: | | SEN: | | SVI: | | TBI: | | AMD: | | AMN: | | AMM: | | PDX: | | AMI: | | SESP: | | STP: | | SAQ: | | MAU: | | MIL: | | VMA: | | AMS: | | ASE: | | CAI: | | SNA: | | AHE: | | MCU: | | BLO: | | BLJ: | | BLN: | | BLON: | | BLF: | | BLL: | | BLB: | | BLM: | | BLK: | | BLG: | | BAD: | | BLA: | | BLC: | | BLT: | | BBB: | | BBC: | | BNM: | | BLV: | | BLW: | | BLS: | | BNI: | | BDE: | | BBI: | | BBP: | | BBF: | | BBV: | | BBRU: | | BAST: | | BTP: | | GVA: | | GVG: | | GVH: | | AFO: | | AYM: | | TAI: | | TLI: | | AMO: | | ATM: | | CAP: | | TTH: | | TTJ: | | TTS: | | TTL: | | TSC: | | THC: | | TOS: | | MRB: | | MRE: | | MSV: | | OPR: | | MHD: | | AAE: | | HYA: | | HHO: | | HYS: | | HTH: | | HTE: | | TAL: | | SUL: | | SAF: | | PMX: | | TAM: | | DTE: | | TMA: | | TPT: | | TLE: | | TRQ: | | TNA: | | TNP: | | TTA: | | TME: | | TAF: | | FNO: | | FPE: | | KOL: | | MPG: | | DTU: | | TYE: | | NDE: | | LFC: | | LFI: | | DDF: | | DAP: | | CNI: | | FSI: | | TID: | | TOP: | | CEX: | | MJA: | | MFE: | | MVU: | | MFS: | | MIF: | | MIG: | | MMP: | | MMQ: | | MMX: | | MMZ: | | MMD: | | MAE: | | MVN: | | MVO: | | MOK: | | MBU: | | MMH: | | MEV: | | MZH: | | MPY: | | MHZ: | | MHU: | | MLA: | | MEM: | | MBG: | | MPI: | | MBN: | | MFO: | | MPL: | | MPD: | | MEZ: | | RCI: | | MTH: | | MMG: | | MST: | | MSI: | | MRU: | | MEL: | | MEW: | | MFV: | | MKA: | | AFU: | | APO: | | AVE: | | AST: | | FPL: | | HAL: | | HSL: | | HMA: | | HHI: | | HWA: | | HWC: | | NPH: | | NMO: | | HLA: | | HUT: | | HMU: | | HTU: | | NMG: | | HVO: | | HME: | | HJE: | | HBO: | | HXA: | | NAT: | | NPE: | | NGE: | | HRU: | | NOU: | | TAC: | | TVO: | | PTO: | | TAR: | | PHO: | | PAB: | | PFU: | | PFI: | | PYN: | | PYA: | | PYS: | | TKO: | | TON: | | TGA: | | TSI: | | TBA: | | THE: | | THA: | | THM: | | ABI: | | ACF: | | MAX: | | APE: | | SMR: | | SHC: | | IHO: | | DKA: | | DMU: | | DFD: | | TAG: | | IAG: | | THG: | | HBU: | | PFM: | | SSO: | | SOL: | | STO: | | SAI: | | SACN: | | SACR: | | SIS: | | SIA: | | SIM: | | SID: | | SIY: | | SIN: | | SII: | | SIH: | | SIR: | | SIC: | | MSE: | | MCN: | | AHO: | | PAI: | | PIS: | | PCL: | | PAS: | | PYR: | | POG: | | TNE: | | CMA: | | TUZ: | | TTN: | | VDI: | | VMO: | | TPE: | | ASC: | | CLG: | | FFO: | | NMR: | | NIR: | | NKR: | | CSY: | | NGA: | | NEQ: | | KCR: | | HAH: | |
» show all
 |
|---|
| Reference |
|
|---|
| Authors |
Roovers M, Wouters J, Bujnicki JM, Tricot C, Stalon V, Grosjean H, Droogmans L |
|---|
| Title |
A primordial RNA modification enzyme: the case of tRNA (m1A) methyltransferase. |
|---|
| Journal |
Nucleic. Acids. Res. 32 (2004) 465-76. |
|---|
| Reference |
|
|---|
| Authors |
Guelorget A, Roovers M, Guerineau V, Barbey C, Li X, Golinelli-Pimpaneau B |
|---|
| Title |
Insights into the hyperthermostability and unusual region-specificity of archaeal Pyrococcus abyssi tRNA m1A57/58 methyltransferase. |
|---|
| Journal |
Nucleic. Acids. Res. 38 (2010) 6206-18. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
|---|
