KEGG   ENZYME: 2.1.1.221Help
Entry
EC 2.1.1.221                Enzyme                                 

Name
tRNA (guanine9-N1)-methyltransferase;
Trm10p (ambiguous);
tRNA(m1G9/m1A9)-methyltransferase;
tRNA(m1G9/m1A9)MTase;
tRNA (guanine-N(1)-)-methyltransferase;
tRNA m1G9-methyltransferase;
tRNA m1G9 MTase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:tRNA (guanine9-N1)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + guanine9 in tRNA = S-adenosyl-L-homocysteine + N1-methylguanine9 in tRNA
Substrate
S-adenosyl-L-methionine [CPD:C00019];
guanine9 in tRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N1-methylguanine9 in tRNA
Comment
The enzyme from Saccharomyces cerevisiae specifically methylates guanine9 [1,2]. The bifunctional enzyme from Thermococcus kodakaraensis also catalyses the methylation of adenine9 in tRNA (cf. EC 2.1.1.218, tRNA (adenine9-N1)-methyltransferase) [1].
History
EC 2.1.1.221 created 2011 (EC 2.1.1.31 created 1971, part transferred 2011 to EC 2.1.1.221)
Orthology
K15445  tRNA (guanine9-N1)-methyltransferase
K15566  tRNA (adenine9-N1/guanine9-N1)-methyltransferase
Genes
HSA: 158234(TRMT10B) 93587(TRMT10A)
PTR: 473128(TRMT10B) 744323(TRMT10A)
PPS: 100972684(TRMT10A) 100982454(TRMT10B)
GGO: 101134503(TRMT10B) 101138560(TRMT10A) 109028343
PON: 100453588(TRMT10B) 100455246(TRMT10A)
NLE: 100580258(TRMT10B) 100588899(TRMT10A)
MCC: 708751(TRMT10A) 716301(TRMT10B)
MCF: 102126911(TRMT10A) 102137541(TRMT10B)
CSAB: 103219172(TRMT10B) 103236029(TRMT10A)
RRO: 104667523(TRMT10B) 104668843(TRMT10A)
RBB: 108515434(TRMT10A) 108516206(TRMT10B)
CJC: 100392858(TRMT10B) 100410417(TRMT10A)
SBQ: 101037386(TRMT10A) 101050174(TRMT10B)
MMU: 108943(Trmt10a) 69934(Trmt10b)
RNO: 295496(Trmt10a) 298081(Trmt10b)
CGE: 100752147(Trmt10b) 100758993(Trmt10a)
NGI: 103728046(Trmt10a) 103745713(Trmt10b)
HGL: 101703119(Trmt10a) 101705943(Trmt10b) 106008803
CCAN: 109682757(Trmt10b) 109697419(Trmt10a)
OCU: 100342674(TRMT10B) 100349170(TRMT10A) 100352086
TUP: 102474033(TRMT10B) 102480415(TRMT10A)
CFA: 481615(TRMT10B) 487872(TRMT10A)
AML: 100474179(TRMT10B) 100479277(TRMT10A)
UMR: 103677926(TRMT10A) 103678487(TRMT10B)
ORO: 101367872(TRMT10A) 101372224(TRMT10B)
FCA: 101080835(TRMT10B) 101099879(TRMT10A)
PTG: 102956580(TRMT10B) 102968663(TRMT10A)
AJU: 106972166(TRMT10A) 106981288(TRMT10B)
BTA: 516258(TRMT10B) 616544(TRMT10A)
BOM: 102267670(TRMT10A) 102285288(TRMT10B)
BIU: 109560314(TRMT10A) 109562520(TRMT10B)
PHD: 102320151(TRMT10A) 102332160(TRMT10B)
CHX: 102179927(TRMT10A) 102189951(TRMT10B)
OAS: 101106656(TRMT10B) 101111193(TRMT10A)
SSC: 100153604(TRMT10B) 100512243(TRMT10A)
CFR: 102514565(TRMT10B) 102524128(TRMT10A)
CDK: 105089546(TRMT10A) 105102257(TRMT10B)
BACU: 103014743(TRMT10B) 103016393(TRMT10A)
LVE: 103072947(TRMT10B) 103087940(TRMT10A)
OOR: 101276300(TRMT10A) 101281659(TRMT10B)
ECB: 100066293(TRMT10B) 100066636(TRMT10A)
EPZ: 103541696(TRMT10B) 103562975(TRMT10A)
EAI: 106834447(TRMT10A) 106843908(TRMT10B)
MYB: 102242600(TRMT10A) 102252973(TRMT10B)
MYD: 102751398(TRMT10B) 102774901(TRMT10A)
HAI: 109386410(TRMT10B) 109392943(TRMT10A)
RSS: 109442561 109446078(TRMT10B) 109461433(TRMT10A)
PALE: 102886904(TRMT10B) 102898955(TRMT10A)
LAV: 100659629(TRMT10A) 100676025(TRMT10B)
MDO: 100015691(TRMT10A) 100018930(TRMT10B)
SHR: 100920234(TRMT10A) 100929718(TRMT10B)
OAA: 100076668(TRMT10A) 100080398(TRMT10B)
GGA: 422708(TRMT10A) 768672(TRMT10B)
MGP: 100546245(TRMT10A) 104915376(TRMT10B)
CJO: 107306733(TRMT10B) 107313676(TRMT10A)
APLA: 101795418(TRMT10B) 101805228(TRMT10A)
ACYG: 106048123(TRMT10A) 106049677(TRMT10B)
TGU: 100231180(TRMT10A) 101233613
GFR: 102031481(TRMT10B) 102038882(TRMT10A)
FAB: 101816287(TRMT10B) 101820930(TRMT10A)
PHI: 102102153(TRMT10B) 102104860(TRMT10A)
PMAJ: 107198420(TRMT10B) 107202993(TRMT10A)
CCW: 104695846(TRMT10B) 104697084(TRMT10A)
FPG: 101911574(TRMT10B)
FCH: 102049437(TRMT10B) 102053593(TRMT10A)
CLV: 102095029(TRMT10B) 102097793(TRMT10A)
EGZ: 104122613(TRMT10A) 104129508(TRMT10B)
AAM: 106487474(TRMT10B) 106491888(TRMT10A)
ASN: 102369982(TRMT10B) 102382962(TRMT10A)
AMJ: 102560334(TRMT10B) 102560464(TRMT10A)
PSS: 102451503(TRMT10B) 102461504(TRMT10A)
CMY: 102937074(TRMT10B) 102947240(TRMT10A)
CPIC: 101936047(TRMT10B) 101953154(TRMT10A)
ACS: 100552544(trmt10a) 100556719(trmt10b)
PVT: 110077853(TRMT10B) 110091499(TRMT10A)
PBI: 103057476(TRMT10B) 103067955(TRMT10A)
GJA: 107107238(TRMT10B) 107114464(TRMT10A)
XLA: 100127324(trmt10a.L) 108706928 108717469
XTR: 100493764(trmt10b) 493374(trmt10a)
NPR: 108793358(TRMT10A) 108799805(TRMT10B)
DRE: 560222(trmt10a) 768135(trmt10b)
SANH: 107679242 107683564 107697470(trmt10b)
CCAR: 109053782 109065196(trmt10a)
IPU: 100528392(trmt10b) 108268295(trmt10a)
AMEX: 103028907(trmt10a) 103041922(trmt10b)
TRU: 101067246(trmt10a) 101072737(trmt10b)
LCO: 104932810(trmt10a) 104938001(trmt10b)
MZE: 101472646 101487910(trmt10b)
OLA: 101156045(trmt10b) 101158639(trmt10a)
XMA: 102218890(trmt10b) 102220141(trmt10a)
PRET: 103475940(trmt10b) 103480094(trmt10a)
NFU: 107377052(trmt10b) 107384750(trmt10a)
CSEM: 103385201(trmt10a) 103388573(trmt10b)
LCF: 108895198(trmt10a) 108903088(trmt10b)
HCQ: 109508380(trmt10b) 109520291(trmt10a)
BPEC: 110170721(trmt10a) 110170741 110170813
ELS: 105022119(trmt10a) 105026753(trmt10b)
SFM: 108920929(trmt10b) 108938807(trmt10a)
LCM: 102352373(TRMT10B) 102359207(TRMT10A)
CMK: 103188744
CIN: 100180545
APLC: 110974158
DME: Dmel_CG14618(CG14618)
DSI: Dsimw501_GD17543(Dsim_GD17543)
MDE: 101889123
AAG: 5571323
AME: 552626
BIM: 100742815
BTER: 100647513
SOC: 105202256
AEC: 105150729
ACEP: 105621778
PBAR: 105426008
HST: 105182772
CFO: 105249108
LHU: 105672394
PGC: 109862662
NVI: 100123238
TCA: 661441
DPA: 109545419
NVL: 108560179
BMOR: 101735637
PMAC: 106710759
PRAP: 110992706
DNX: 107162982
ZNE: 110833855
TUT: 107361851
CEL: CELE_F25H8.1(F25H8.1)
CBR: CBG03455
BMY: Bm1_08270
MYI: 110447466
SHX: MS3_02555
HMG: 100212147
ATH: AT5G47680(TRM10)
CRB: 17876578
THJ: 104806738
CPAP: 110817976
CIT: 102610017
TCC: 18597303
GRA: 105769160
EGR: 104445589
VRA: 106775078
VAR: 108341817
CCAJ: 109803895
CAM: 101492246
ADU: 107483054
AIP: 107638754
LJA: Lj6g3v1719540.1(Lj6g3v1719540.1)
LANG: 109330373
FVE: 101296806
PPER: 109948582
PMUM: 103324402
PAVI: 110768606
PXB: 103963724
ZJU: 107407391
CSV: 101213428
CMO: 103502202
CMAX: 111471663
CMOS: 111434383
CPEP: 111784115
RCU: 8261745
JCU: 105636208
HBR: 110671617
JRE: 109003615
SLY: 101266686
SPEN: 107004433
SOT: 102584959
CANN: 107850351
NSY: 104231553
NTO: 104104950
INI: 109174639
SIND: 105175230
OEU: 111407181
HAN: 110918597
LSV: 111886228
BVG: 104901439
SOE: 110779742
NNU: 104594260
OSA: 4330585
DOSA: Os02t0725600-01(Os02g0725600)
OBR: 102715548
BDI: 100829706
ATS: 109761195(LOC109761195)
SBI: 8077712
SITA: 101776127
PDA: 103718440
EGU: 105049959
MUS: 103977859
AOF: 109840232
ATR: 18447634
APRO: F751_3280
SCE: YOL093W(TRM10)
ERC: Ecym_2793
KMX: KLMA_10168(TRM10)
NCS: NCAS_0A08700(NCAS0A08700)
NDI: NDAI_0G05140(NDAI0G05140)
TPF: TPHA_0A00720(TPHA0A00720)
TBL: TBLA_0B02360(TBLA0B02360)
TDL: TDEL_0D05200(TDEL0D05200)
KAF: KAFR_0C01370(KAFR0C01370)
CAL: CAALFM_C206480WA(CaO19.25)
CAUR: QG37_07782
SLB: AWJ20_1227(TRM10)
NCR: NCU02231
NTE: NEUTE1DRAFT131414(NEUTE1DRAFT_131414)
MGR: MGG_00880
MAW: MAC_04668
MAJ: MAA_04553
CMT: CCM_01338
MBE: MBM_06831
ANI: AN3010.2
ANG: ANI_1_1538144(An16g02140)
PBL: PAAG_12544(PAAG_08353)
ABE: ARB_04688
TVE: TRV_03130
PTE: PTT_09079
SPO: SPAC6B12.09(trm10)
CNE: CNC05170
CNB: CNBC2000
MGL: MGL_1292
DFA: DFA_04330
EHI: EHI_106680(217.t00006) EHI_168400(191.t00001)
PYO: PY17X_0931000(PY04675)
PCB: PCHAS_091530(PC000854.02.0)
TAN: TA07045
TPV: TP04_0062
BBO: BBOV_III002590(17.m07247)
SMIN: v1.2.026982.t2(symbB.v1.2.026982.t2)
MKA: MK1026
AFU: AF_0031
FPL: Ferp_2241
GAC: GACE_1058
GAH: GAH_01558
PHO: PH0711(PH0711)
PAB: PAB0880
PFU: PF0678
PFI: PFC_02550
PYN: PNA2_1359
PYS: Py04_0749
TKO: TK0422
TON: TON_0675
TGA: TGAM_0680
TSI: TSIB_0970
THE: GQS_01580
THA: TAM4_954
THM: CL1_2027
TLT: OCC_05461
THS: TES1_0839
TNU: BD01_0565
TEU: TEU_09285
PPAC: PAP_07635
APE: APE_0498
ACJ: ACAM_0386
IHO: Igni_0721
IIS: EYM_07625
IAG: Igag_1267
HBU: Hbut_0079
SSO: SSO1087
SOL: Ssol_2061
SSOA: SULA_2093
SSOL: SULB_2094
SSOF: SULC_2092
STO: STK_08530
SAI: Saci_1677
SID: M164_1128
SII: LD85_1255
SIH: SiH_1099
SIR: SiRe_1012
SIC: SiL_1021
MSE: Msed_1469
MCN: Mcup_0756
AHO: Ahos_0922
PAI: PAE0001
PIS: Pisl_0031
PCL: Pcal_0647
PAS: Pars_1096
PYR: P186_0834
POG: Pogu_1177
TNE: Tneu_0946
CMA: Cmaq_1633
TUZ: TUZN_0832
TTN: TTX_0355
VDI: Vdis_0727
VMO: VMUT_1574
ASC: ASAC_0477
NEQ: NEQ005
NAA: Nps_02650
 » show all
Taxonomy
Reference
1  [PMID:20525789]
  Authors
Kempenaers M, Roovers M, Oudjama Y, Tkaczuk KL, Bujnicki JM, Droogmans L
  Title
New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA.
  Journal
Nucleic. Acids. Res. 38 (2010) 6533-43.
  Sequence
[tko:TK0422]
Reference
2  [PMID:12702816]
  Authors
Jackman JE, Montange RK, Malik HS, Phizicky EM
  Title
Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9.
  Journal
RNA. 9 (2003) 574-85.
  Sequence
[sce:YOL093W]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.221
IUBMB Enzyme Nomenclature: 2.1.1.221
ExPASy - ENZYME nomenclature database: 2.1.1.221
BRENDA, the Enzyme Database: 2.1.1.221

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