KEGG   ENZYME: 2.1.1.230Help
Entry
EC 2.1.1.230                Enzyme                                 

Name
23S rRNA (adenosine1067-2'-O)-methyltransferase;
23S rRNA A1067 2'-methyltransferase;
thiostrepton-resistance methylase;
nosiheptide-resistance methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:23S rRNA (adenosine1067-2'-O)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + adenosine1067 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methyladenosine1067 in 23S rRNA
Substrate
S-adenosyl-L-methionine [CPD:C00019];
adenosine1067 in 23S rRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
2'-O-methyladenosine1067 in 23S rRNA
Comment
The methylase that is responsible for autoimmunity in the thiostrepton producer Streptomyces azureus, renders ribosomes completely resistant to thiostrepton [2].
History
EC 2.1.1.230 created 2011
Orthology
K05926  
23S rRNA (adenosine1067-2'-O)-methyltransferase
Genes
CGY: 
CMV: 
STRE: 
CFL: 
NAL: 
Taxonomy
Reference
1  [PMID:7925357]
  Authors
Bechthold A, Floss HG
  Title
Overexpression of the thiostrepton-resistance gene from Streptomyces azureus in Escherichia coli and characterization of recognition sites of the 23S rRNA A1067  2'-methyltransferase in the guanosine triphosphatase center of 23S ribosomal RNA.
  Journal
Eur. J. Biochem. 224 (1994) 431-7.
Reference
2  [PMID:6806287]
  Authors
Thompson J, Schmidt F, Cundliffe E
  Title
Site of action of a ribosomal RNA methylase conferring resistance to thiostrepton.
  Journal
J. Biol. Chem. 257 (1982) 7915-7.
Reference
3
  Authors
Thompson, J. and Cundliffe, E.
  Title
Purification and properties of an RNA methylase produced by Streptomyces azureus and involved in resistance to thiostrepton.
  Journal
J. Gen. Microbiol. 124 (1981) 291-297.
Reference
4  [PMID:20550164]
  Authors
Yang H, Wang Z, Shen Y, Wang P, Jia X, Zhao L, Zhou P, Gong R, Li Z, Yang Y, Chen D, Murchie AI, Xu Y
  Title
Crystal structure of the nosiheptide-resistance methyltransferase of Streptomyces actuosus.
  Journal
Biochemistry. 49 (2010) 6440-50.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system