KEGG   ENZYME: 2.1.1.233Help
Entry
EC 2.1.1.233                Enzyme                                 

Name
[phosphatase 2A protein]-leucine-carboxy methyltransferase;
leucine carboxy methyltransferase-1;
LCMT1
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:[phosphatase 2A protein]-leucine O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine = S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[phosphatase 2A protein]-leucine
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[phosphatase 2A protein]-leucine methyl ester
Comment
Methylates the C-terminal leucine of phosphatase 2A. A key regulator of protein phosphatase 2A. The methyl ester is hydrolysed by EC 3.1.1.89 (protein phosphatase methylesterase-1). Occurs mainly in the cytoplasm, Golgi region and late endosomes.
History
EC 2.1.1.233 created 2011
Orthology
K18203  [phosphatase 2A protein]-leucine-carboxy methyltransferase
Genes
HSA: 51451(LCMT1)
PTR: 467930(LCMT1)
PPS: 100987316(LCMT1)
GGO: 101148281(LCMT1)
PON: 100443208(LCMT1)
NLE: 100606762(LCMT1)
MCC: 702050(LCMT1)
MCF: 102124303(LCMT1)
CSAB: 103229986(LCMT1)
RRO: 104661764(LCMT1)
RBB: 108538865(LCMT1)
CJC: 100397919(LCMT1)
SBQ: 101042382(LCMT1)
MMU: 30949(Lcmt1)
RNO: 361643(Lcmt1)
CGE: 100762400(Lcmt1)
NGI: 103746920(Lcmt1)
HGL: 101699863(Lcmt1)
CCAN: 109699800(Lcmt1)
OCU: 100350737(LCMT1)
TUP: 102491269(LCMT1)
CFA: 608360(LCMT1)
AML: 100464868(LCMT1)
UMR: 103657800(LCMT1)
ORO: 101374301 101386951(LCMT1)
FCA: 102900324 102901317(LCMT1)
PTG: 102951671(LCMT1)
AJU: 106966161(LCMT1) 106969140
BTA: 618021(LCMT1)
BOM: 102268025(LCMT1)
BIU: 109578134(LCMT1)
PHD: 102315320(LCMT1)
CHX: 102174529(LCMT1)
OAS: 101107755(LCMT1)
CFR: 102503513(LCMT1) 102516944
CDK: 105094842(LCMT1)
BACU: 103015136(LCMT1)
LVE: 103069896(LCMT1)
OOR: 101279381(LCMT1)
ECB: 100061739(LCMT1)
EPZ: 103564488(LCMT1)
EAI: 106826671(LCMT1)
MYB: 102239060(LCMT1)
MYD: 102773182(LCMT1)
HAI: 109386551(LCMT1)
RSS: 109457358(LCMT1)
PALE: 102879909(LCMT1)
LAV: 100673711(LCMT1)
TMU: 101348585
MDO: 100014639(LCMT1)
SHR: 100923755(LCMT1) 100931912
OAA: 100074396(LCMT1)
GGA: 416565(LCMT1)
MGP: 100538645(LCMT1)
CJO: 107320771(LCMT1)
APLA: 101789500(LCMT1)
ACYG: 106046047(LCMT1)
TGU: 100231820(LCMT1)
GFR: 102041579(LCMT1)
FAB: 101820295(LCMT1)
PHI: 102104644(LCMT1)
PMAJ: 107211153(LCMT1)
CCW: 104684990(LCMT1)
FPG: 101920570(LCMT1)
FCH: 102054412(LCMT1)
CLV: 102090659(LCMT1)
EGZ: 104134540(LCMT1)
AAM: 106486210(LCMT1)
ASN: 102368372(LCMT1)
AMJ: 102572102(LCMT1)
PSS: 102449721(LCMT1)
CMY: 102929388(LCMT1)
CPIC: 101952389(LCMT1)
ACS: 100557653(lcmt1)
PVT: 110085038(LCMT1)
PBI: 103062236(LCMT1)
GJA: 107110581(LCMT1)
XLA: 108703202(lcmt1.S) 734508(lcmt1.L)
XTR: 548787(lcmt1)
NPR: 108791006(LCMT1)
DRE: 447907(lcmt1)
IPU: 100528205(lcmt1)
TRU: 101066473(lcmt1)
LCO: 104918937(lcmt1)
MZE: 101468727(lcmt1)
OLA: 101171444(lcmt1)
XMA: 102230867(lcmt1)
PRET: 103481011(lcmt1)
NFU: 107388130(lcmt1)
CSEM: 103382315(lcmt1)
LCF: 108890779(lcmt1)
HCQ: 109508176(lcmt1)
BPEC: 110159694(lcmt1)
SASA: 100196453(lcmt1)
ELS: 105031147(lcmt1)
SFM: 108939947(lcmt1)
LCM: 102365484(LCMT1)
CMK: 103178665(lcmt1)
CIN: 100186621
SPU: 584645
APLC: 110989479
SKO: 100376437
DSI: Dsimw501_GD24020(Dsim_GD24020)
MDE: 101894021
AAG: 5565351
AME: 409320
BIM: 100740367
BTER: 100651839
SOC: 105200553
AEC: 105149520
ACEP: 105622441
PBAR: 105429881
HST: 105188089
CFO: 105251585
LHU: 105667309
PGC: 109854607
NVI: 100118221
TCA: 103315159
DPA: 109535976
NVL: 108562734
BMOR: 101743540
PMAC: 106710887
PRAP: 110996060
API: 100163289
DNX: 107163947
ZNE: 110832872
FCD: 110852810
TUT: 107366960
CEL: CELE_B0285.4(lcmt-1)
CBR: CBG18087
BMY: Bm1_32700
TSP: Tsp_08223
CRG: 105343554
MYI: 110467257
OBI: 106874329
SHX: MS3_08012
EPA: 110241094
HMG: 100200532
AQU: 100636740
SCE: YDR435C(PPM1)
ERC: Ecym_4082
KMX: KLMA_40597(PPM1)
NCS: NCAS_0F01180(NCAS0F01180)
NDI: NDAI_0H01700(NDAI0H01700)
TPF: TPHA_0K00430(TPHA0K00430)
TBL: TBLA_0D01520(TBLA0D01520)
TDL: TDEL_0A04100(TDEL0A04100)
KAF: KAFR_0E03210(KAFR0E03210)
PIC: PICST_28852(PPM1)
CAL: CAALFM_CR08170CA(CaO19.6377)
CAUR: QG37_00750
SLB: AWJ20_4436(PPM1)
NCR: NCU07993
NTE: NEUTE1DRAFT128865(NEUTE1DRAFT_128865)
MGR: MGG_01758
MAJ: MAA_06485
CMT: CCM_05360
BFU: BCIN_07g06610(Bcppm1)
MBE: MBM_01610
ANI: AN9438.2
ANG: ANI_1_2090074(An08g07080)
PBN: PADG_11158(PADG_00858)
PNO: SNOG_02904(SNOG_02903)
PTE: PTT_16481
CNE: CNB04800
CNB: CNBB0940
ABP: AGABI1DRAFT56526(AGABI1DRAFT_56526)
ABV: AGABI2DRAFT204952(AGABI2DRAFT_204952)
MGL: MGL_0125
SPAR: SPRG_09071
 » show all
Taxonomy
Reference
1  [PMID:10600115]
  Authors
De Baere I, Derua R, Janssens V, Van Hoof C, Waelkens E, Merlevede W, Goris J
  Title
Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue.
  Journal
Biochemistry. 38 (1999) 16539-47.
  Sequence
[hsa:51451]
Reference
2  [PMID:21206058]
  Authors
Tsai ML, Cronin N, Djordjevic S
  Title
The structure of human leucine carboxyl methyltransferase 1 that regulates protein phosphatase PP2A.
  Journal
Acta. Crystallogr. D. Biol. Crystallogr. 67 (2011) 14-24.
  Sequence
[hsa:51451]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.233
IUBMB Enzyme Nomenclature: 2.1.1.233
ExPASy - ENZYME nomenclature database: 2.1.1.233
BRENDA, the Enzyme Database: 2.1.1.233

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