KEGG   ENZYME: 2.1.1.233Help
Entry
EC 2.1.1.233                Enzyme                                 

Name
[phosphatase 2A protein]-leucine-carboxy methyltransferase;
leucine carboxy methyltransferase-1;
LCMT1
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:[phosphatase 2A protein]-leucine O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine = S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[phosphatase 2A protein]-leucine
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[phosphatase 2A protein]-leucine methyl ester
Comment
Methylates the C-terminal leucine of phosphatase 2A. A key regulator of protein phosphatase 2A. The methyl ester is hydrolysed by EC 3.1.1.89 (protein phosphatase methylesterase-1). Occurs mainly in the cytoplasm, Golgi region and late endosomes.
History
EC 2.1.1.233 created 2011
Orthology
K18203  
[phosphatase 2A protein]-leucine-carboxy methyltransferase
Genes
HSA: 
51451(LCMT1)
PTR: 
467930(LCMT1)
PPS: 
100987316(LCMT1)
GGO: 
PON: 
100443208(LCMT1)
NLE: 
100606762(LCMT1)
MCC: 
702050(LCMT1)
MCF: 
102124303(LCMT1)
RRO: 
104661764(LCMT1)
CJC: 
100397919(LCMT1)
MMU: 
30949(Lcmt1)
RNO: 
361643(Lcmt1)
CGE: 
100762400(Lcmt1)
NGI: 
103746920(Lcmt1)
HGL: 
101699863(Lcmt1)
OCU: 
100350737(LCMT1)
TUP: 
102491269(LCMT1)
CFA: 
608360(LCMT1)
AML: 
100464868(LCMT1)
UMR: 
103657800(LCMT1)
FCA: 
PTG: 
102951671(LCMT1)
BTA: 
618021(LCMT1)
BOM: 
102268025(LCMT1)
PHD: 
102315320(LCMT1)
CHX: 
102174529(LCMT1)
OAS: 
101107755(LCMT1)
SSC: 
CFR: 
BACU: 
103015136(LCMT1)
LVE: 
103069896(LCMT1)
ECB: 
100061739(LCMT1)
MYB: 
102239060(LCMT1)
MYD: 
102773182(LCMT1)
PALE: 
102879909(LCMT1)
MDO: 
100014639(LCMT1)
SHR: 
OAA: 
100074396(LCMT1)
GGA: 
416565(LCMT1)
MGP: 
100538645(LCMT1)
CJO: 
107320771(LCMT1)
APLA: 
101789500(LCMT1)
TGU: 
100231820(LCMT1)
GFR: 
102041579(LCMT1)
FAB: 
101820295(LCMT1)
PHI: 
102104644(LCMT1)
CCW: 
104684990(LCMT1)
FPG: 
101920570(LCMT1)
FCH: 
102054412(LCMT1)
CLV: 
102090659(LCMT1)
AAM: 
106486210(LCMT1)
ASN: 
102368372(LCMT1)
AMJ: 
102572102(LCMT1)
PSS: 
102449721(LCMT1)
CMY: 
102929388(LCMT1)
ACS: 
100557653(lcmt1)
PBI: 
103062236(LCMT1)
GJA: 
107110581(LCMT1)
XLA: 
734508(lcmt1)
XTR: 
548787(lcmt1)
DRE: 
447907(lcmt1)
TRU: 
101066473(lcmt1)
MZE: 
101468727(lcmt1)
OLA: 
101171444(lcmt1)
XMA: 
102230867(lcmt1)
LCM: 
102365484(LCMT1)
CMK: 
103178665(lcmt1)
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD24020(Dsim_GD24020)
DWI: 
DYA: 
Dyak_GE21133(dyak_GLEANR_492)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
409320(GB14413)
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_B0285.4(B0285.4)
CBR: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
NVE: 
TAD: 
AQU: 
SCE: 
YDR435C(PPM1)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0F01180(NCAS0F01180)
NDI: 
NDAI_0H01700(NDAI0H01700)
TPF: 
TPHA_0K00430(TPHA0K00430)
TBL: 
TBLA_0D01520(TBLA0D01520)
TDL: 
TDEL_0A04100(TDEL0A04100)
KAF: 
KAFR_0E03210(KAFR0E03210)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
NTE: 
NEUTE1DRAFT128865(NEUTE1DRAFT_128865)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
NHE: 
TRE: 
MAJ: 
CMT: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
ANG: 
ANI_1_2090074(An08g07080)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
PBN: 
PADG_11158(PADG_00858)
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BSC: 
ZTR: 
PFJ: 
BCOM: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
DSQ: 
PCO: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT56526(AGABI1DRAFT_56526)
ABV: 
AGABI2DRAFT204952(AGABI2DRAFT_204952)
CPUT: 
SLA: 
WSE: 
WIC: 
PFP: 
MGL: 
PGR: 
MLR: 
SRE: 
AAF: 
SPAR: 
LDO: 
LMI: 
 » show all
Taxonomy
Reference
1  [PMID:10600115]
  Authors
De Baere I, Derua R, Janssens V, Van Hoof C, Waelkens E, Merlevede W, Goris J
  Title
Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue.
  Journal
Biochemistry. 38 (1999) 16539-47.
  Sequence
[hsa:51451]
Reference
2  [PMID:21206058]
  Authors
Tsai ML, Cronin N, Djordjevic S
  Title
The structure of human leucine carboxyl methyltransferase 1 that regulates protein phosphatase PP2A.
  Journal
Acta. Crystallogr. D. Biol. Crystallogr. 67 (2011) 14-24.
  Sequence
[hsa:51451]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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