KEGG   ENZYME: 2.1.1.240Help
Entry
EC 2.1.1.240                Enzyme                                 

Name
trans-resveratrol di-O-methyltransferase;
ROMT;
resveratrol O-methyltransferase;
pterostilbene synthase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:trans-resveratrol 3,5-O-dimethyltransferase
Reaction(IUBMB)
2 S-adenosyl-L-methionine + trans-resveratrol = 2 S-adenosyl-L-homocysteine + pterostilbene (overall reaction) [RN:R09872];
(1a) S-adenosyl-L-methionine + trans-resveratrol = S-adenosyl-L-homocysteine + 3-methoxy-4',5-dihydroxy-trans-stilbene [RN:R09870];
(1b) S-adenosyl-L-methionine + 3-methoxy-4',5-dihydroxy-trans-stilbene = S-adenosyl-L-homocysteine + pterostilbene [RN:R09871]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
trans-resveratrol [CPD:C03582];
3-methoxy-4',5-dihydroxy-trans-stilbene [CPD:C20154]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
pterostilbene [CPD:C10287];
3-methoxy-4',5-dihydroxy-trans-stilbene [CPD:C20154]
Comment
The enzyme catalyses the biosynthesis of pterostilbene from resveratrol.
History
EC 2.1.1.240 created 2012
Pathway
Stilbenoid, diarylheptanoid and gingerol biosynthesis
Orthology
K16040  
trans-resveratrol di-O-methyltransferase
Genes
VVI: 
100233030(OMT2.1)
Taxonomy
Reference
1  [PMID:18799660]
  Authors
Schmidlin L, Poutaraud A, Claudel P, Mestre P, Prado E, Santos-Rosa M, Wiedemann-Merdinoglu S, Karst F, Merdinoglu D, Hugueney P
  Title
A stress-inducible resveratrol O-methyltransferase involved in the biosynthesis of pterostilbene in grapevine.
  Journal
Plant. Physiol. 148 (2008) 1630-9.
  Organism
Vitis vinifera
  Sequence
[vvi:100233030]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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