KEGG   ENZYME: 2.1.1.245Help
Entry
EC 2.1.1.245                Enzyme                                 
Name
5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase;
cdhD (gene name);
cdhE (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein methyltransferase
Reaction(IUBMB)
a [methyl-Co(III) corrinoid Fe-S protein] + tetrahydrosarcinapterin = a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrosarcinapterin
Substrate
[methyl-Co(III) corrinoid Fe-S protein];
tetrahydrosarcinapterin [CPD:C18802]
Product
[Co(I) corrinoid Fe-S protein];
5-methyltetrahydrosarcinapterin
Comment
Catalyses the transfer of a methyl group from the cobamide cofactor of a corrinoid/Fe-S protein to the N5 group of tetrahydrosarcinapterin. Forms, together with EC 1.2.7.4, carbon-monoxide dehydrogenase (ferredoxin) and EC 2.3.1.169, CO-methylating acetyl-CoA synthase, the acetyl-CoA decarbonylase/synthase complex that catalyses the demethylation of acetyl-CoA in a reaction that also forms CO2. This reaction is a key step in methanogenesis from acetate.
Pathway
Microbial metabolism in diverse environments
Orthology
K00194  
acetyl-CoA decarbonylase/synthase complex subunit delta
K00197  
acetyl-CoA decarbonylase/synthase complex subunit gamma
Genes
GUR: 
DAK: 
DSF: 
DOL: 
DAL: 
DAT: 
DTO: 
SAT: 
DAO: 
DTI: 
SFU: 
Sfum_2564 Sfum_2567
DBR: 
Deba_0239 Deba_0243
CLJ: 
CLJU_c37570 CLJU_c37580
CDF: 
CD630_07250 CD630_07260
CDC: 
CD196_0671 CD196_0672
CDL: 
CDR20291_0652 CDR20291_0653
CDG: 
CDBI1_03465 CDBI1_03470
CST: 
CLOST_1168 CLOST_1169
AMT: 
Amet_2025 Amet_2026
DSY: 
DSY1648 DSY1651
DHD: 
Dhaf_2793 Dhaf_2796
DDH: 
Desde_2251 Desde_2254
DDL: 
Desdi_1917 Desdi_1920
DAE: 
Dtox_1272 Dtox_1275
DKU: 
Desku_1488 Desku_1490
PTH: 
PTH_1001(CdhE) PTH_1003(CdhD)
DAU: 
Daud_0112 Daud_0114 Daud_0872 Daud_0875
TJR: 
TherJR_1159 TherJR_1160
DOR: 
Desor_3269 Desor_3272
DAI: 
Desaci_2970 Desaci_2973
DMI: 
Desmer_2531 Desmer_2534
DED: 
DHBDCA_p226(acsC) DHBDCA_p227(acsD)
DEC: 
DCF50_p286(acsC) DCF50_p287(acsD)
ELM: 
ELI_3605 ELI_3606
AWO: 
Awo_c10710(acsD) Awo_c10720(acsC)
RUM: 
CK1_12650 CK1_12660
ROB: 
CK5_28660 CK5_28670
CHY: 
CHY_1223(acsC) CHY_1226(acsD)
TEP: 
TepRe1_0558 TepRe1_0559
TAE: 
TEPIRE1_6220 TEPIRE1_6230
MTA: 
Moth_1198 Moth_1201
ADG: 
Adeg_0337 Adeg_0340
TPZ: 
Tph_c15140(acsD) Tph_c15160(acsC)
TOC: 
Toce_0810 Toce_0811
AAR: 
Acear_1300 Acear_1303
TAZ: 
TREAZ_1645 TREAZ_1647
TPI: 
TREPR_3065 TREPR_3066
DET: 
DET0665(acsC-1) DET0667(acsD-1) DET0699(acsC-2) DET0701(acsD-2)
DEH: 
cbdb_A651(acsC) cbdb_A654(acsD)
DEB: 
DehaBAV1_0634 DehaBAV1_0636
DEV: 
DhcVS_603(cdhE) DhcVS_605(cdhD)
DEG: 
DehalGT_0596 DehalGT_0598
DMC: 
btf_621(acsC) btf_623(acsD)
DMD: 
dcmb_667(acsC) dcmb_669(acsD)
DLY: 
Dehly_0816 Dehly_0818
TYE: 
THEYE_A1471 THEYE_A1472
TID: 
Thein_2182
TOP: 
TOPB45_0393
MJA: 
MJ_0112 MJ_0113
MFE: 
Mefer_0823 Mefer_0824
MVU: 
Metvu_1052 Metvu_1053
MFS: 
MFS40622_0985 MFS40622_0986
MIF: 
Metin_1344 Metin_1345
MIG: 
Metig_1085 Metig_1086
MMP: 
MMP0980(cdh) MMP0981(cdhD)
MMQ: 
MmarC5_0800 MmarC5_0801
MMX: 
MmarC6_1677 MmarC6_1678
MMZ: 
MmarC7_0222 MmarC7_0223
MMD: 
GYY_05725 GYY_05730
MAE: 
Maeo_0210 Maeo_0211
MVN: 
Mevan_0306 Mevan_0307
MOK: 
Metok_0141 Metok_0142
MAC: 
MA1011(cdhE) MA1012(cdhD) MA3864(cdhD) MA3865(cdhE)
MBA: 
Mbar_A0199 Mbar_A0200 Mbar_A0429 Mbar_A0430
MMA: 
MM_0688 MM_0689 MM_2084 MM_2085
MMAZ: 
MmTuc01_2152 MmTuc01_2153
MBU: 
Mbur_0862 Mbur_0863
MMH: 
Mmah_1170 Mmah_1171
MEV: 
Metev_0421 Metev_0422
MZH: 
Mzhil_1132 Mzhil_1133
MPY: 
Mpsy_2890 Mpsy_2891
MHZ: 
Metho_0979 Metho_0980
MTP: 
Mthe_0287 Mthe_0288
MCJ: 
MCON_1325(cdhE) MCON_1326(cdhD)
MHI: 
Mhar_2322 Mhar_2323
MHU: 
Mhun_0686 Mhun_0687
MBG: 
BN140_2373(acsC) BN140_2374(acsD)
MBN: 
Mboo_1195 Mboo_1369 Mboo_1370
MFO: 
Metfor_1454 Metfor_1455 Metfor_1717 Metfor_1718
MPL: 
Mpal_0804 Mpal_0805
RCI: 
LRC461(cdhD) LRC463(cdhE)
MTH: 
MTH1712 MTH1713
MMG: 
MTBMA_c02910(cdhD) MTBMA_c02920(cdhE)
MEL: 
Metbo_0466 Metbo_0467
MEW: 
MSWAN_1929 MSWAN_1930
MFV: 
Mfer_0522 Mfer_0523
MKA: 
MK0722(CdhD) MK0723(CdhE)
AFU: 
AF0376(cdhE) AF0377(cdhD)
AVE: 
Arcve_1125 Arcve_1126
FPL: 
Ferp_0735 Ferp_0736
 » show all
Taxonomy
Reference
1  [PMID:8550451]
  Authors
Maupin-Furlow J, Ferry JG
  Title
Characterization of the cdhD and cdhE genes encoding subunits of the corrinoid/iron-sulfur enzyme of the CO dehydrogenase complex from Methanosarcina  thermophila.
  Journal
J. Bacteriol. 178 (1996) 340-6.
Reference
2  [PMID:8626532]
  Authors
Grahame DA, DeMoll E.
  Title
Partial reactions catalyzed by protein components of the acetyl-CoA decarbonylase synthase enzyme complex from Methanosarcina barkeri.
  Journal
J. Biol. Chem. 271 (1996) 8352-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system