KEGG   ENZYME: 2.1.1.245Help
Entry
EC 2.1.1.245                Enzyme                                 

Name
5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase;
cdhD (gene name);
cdhE (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein methyltransferase
Reaction(IUBMB)
a [methyl-Co(III) corrinoid Fe-S protein] + tetrahydrosarcinapterin = a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrosarcinapterin [RN:R10385]
Reaction(KEGG)
Substrate
[methyl-Co(III) corrinoid Fe-S protein];
tetrahydrosarcinapterin [CPD:C18802]
Product
[Co(I) corrinoid Fe-S protein];
5-methyltetrahydrosarcinapterin [CPD:C18799]
Comment
Catalyses the transfer of a methyl group from the cobamide cofactor of a corrinoid/Fe-S protein to the N5 group of tetrahydrosarcinapterin. Forms, together with EC 1.2.7.4, carbon-monoxide dehydrogenase (ferredoxin) and EC 2.3.1.169, CO-methylating acetyl-CoA synthase, the acetyl-CoA decarbonylase/synthase complex that catalyses the demethylation of acetyl-CoA in a reaction that also forms CO2. This reaction is a key step in methanogenesis from acetate.
History
EC 2.1.1.245 created 2012
Pathway
Microbial metabolism in diverse environments
Orthology
K00194  
acetyl-CoA decarbonylase/synthase complex subunit delta
K00197  
acetyl-CoA decarbonylase/synthase complex subunit gamma
Genes
GUR: 
DAK: 
DSF: 
DOL: 
DAL: 
DAT: 
DTO: 
SAT: 
DAO: 
DTI: 
SFU: 
DBR: 
CLJ: 
CAH: 
AMT: 
RUM: 
ROB: 
CDF: 
CDC: 
CDL: 
CDG: 
CST: 
DSY: 
DHD: 
DDH: 
DDL: 
DAE: 
DKU: 
DGI: 
PTH: 
PTH_1001(CdhE) PTH_1003(CdhD)
DAU: 
TJR: 
DOR: 
DAI: 
DMI: 
DED: 
DEC: 
DRS: 
ELM: 
AWO: 
TKI: 
CHY: 
CHY_1223(acsC) CHY_1226(acsD)
TEP: 
TAE: 
MTA: 
ADG: 
TPZ: 
TOC: 
AAR: 
TAZ: 
TPI: 
DET: 
DET0665(acsC-1) DET0667(acsD-1) DET0699(acsC-2) DET0701(acsD-2)
DEH: 
cbdb_A651(acsC) cbdb_A654(acsD)
DEB: 
DEV: 
DhcVS_603(cdhE) DhcVS_605(cdhD)
DEG: 
DMC: 
btf_621(acsC) btf_623(acsD)
DMD: 
dcmb_667(acsC) dcmb_669(acsD)
DMG: 
GY50_0590(cdhE) GY50_0592(cdhD)
DLY: 
TYE: 
TID: 
TOP: 
TCM: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMP0980(cdh) MMP0981(cdhD)
MMQ: 
MMX: 
MMZ: 
MMD: 
MAE: 
MVN: 
MOK: 
MAC: 
MA1011(cdhE) MA1012(cdhD) MA3864(cdhD) MA3865(cdhE)
MBA: 
MMA: 
MMAZ: 
MBU: 
MMH: 
MEV: 
MZH: 
MPY: 
MHZ: 
MTP: 
MCJ: 
MCON_1325(cdhE) MCON_1326(cdhD)
MHI: 
MHU: 
MBG: 
MBN: 
MFO: 
MPL: 
RCI: 
LRC461(cdhD) LRC463(cdhE)
MER: 
MTH: 
MMG: 
MEL: 
MEW: 
METH: 
MFC: 
BRM9_0796(cdhE) BRM9_0797(cdhD)
MFV: 
MKA: 
MK0722(CdhD) MK0723(CdhE)
AFU: 
AF0376(cdhE) AF0377(cdhD)
AFG: 
AVE: 
AST: 
FPL: 
 » show all
Taxonomy
Reference
1  [PMID:8550451]
  Authors
Maupin-Furlow J, Ferry JG
  Title
Characterization of the cdhD and cdhE genes encoding subunits of the corrinoid/iron-sulfur enzyme of the CO dehydrogenase complex from Methanosarcina  thermophila.
  Journal
J. Bacteriol. 178 (1996) 340-6.
  Sequence
[up:Q50539]
Reference
2  [PMID:8626532]
  Authors
Grahame DA, DeMoll E.
  Title
Partial reactions catalyzed by protein components of the acetyl-CoA decarbonylase synthase enzyme complex from Methanosarcina barkeri.
  Journal
J. Biol. Chem. 271 (1996) 8352-8.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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