KEGG   ENZYME: 2.1.1.246Help
Entry
EC 2.1.1.246                Enzyme                                 

Name
[methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase;
methyltransferase 2 (ambiguous);
mtaA (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
methylated methanol-specific corrinoid protein:coenzyme M methyltransferase
Reaction(IUBMB)
a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M = methyl-CoM + a [Co(I) methanol-specific corrinoid protein] [RN:R10000]
Reaction(KEGG)
R10000;
(other) R09098
Show
Substrate
[methyl-Co(III) methanol-specific corrinoid protein];
coenzyme M [CPD:C03576]
Product
methyl-CoM [CPD:C03920];
[Co(I) methanol-specific corrinoid protein]
Comment
The enzyme, which is involved in methanogenesis from methanol, catalyses the transfer of a methyl group from a corrinoid protein (see EC 2.1.1.90, methanol---corrinoid protein Co-methyltransferase), where it is bound to the cobalt cofactor, to coenzyme M, forming the substrate for EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase, the enzyme that catalyses the final step in methanogenesis. Free methylcob(I)alamin can substitute for the corrinoid protein in vitro [5].
History
EC 2.1.1.246 created 2012
Pathway
Methane metabolism
Microbial metabolism in diverse environments
Orthology
K14080  
[methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase
Genes
GEO: 
DTI: 
CBO: 
CBO1495(mtbA)
CBA: 
CBH: 
CBY: 
CBL: 
CBB: 
CBI: 
CBF: 
CBM: 
CBJ: 
CLJ: 
CCB: 
CAH: 
CSQ: 
CLD: 
CACE: 
CCK: 
CTH: 
CTX: 
CCL: 
CAD: 
CST: 
SWO: 
DSY: 
DHD: 
DKU: 
TJR: 
SGY: 
DOR: 
DMI: 
MTA: 
TOC: 
SRI: 
PUF: 
SHI: 
TAZ: 
TPI: 
TPK: 
MMP: 
MMP0831(mtbA)
MMQ: 
MMX: 
MMZ: 
MMD: 
MMAK: 
MMAO: 
MVO: 
MAC: 
MA_0779(cmtM) MA_0855(mtaA) MA_1615(cmtM) MA_2163(cmtM) MA_3613(cmtM) MA_4379(mtaA) MA_4559(cmtM)
MBA: 
MBY: 
MBW: 
MBAR: 
MMA: 
MM_0176(mtaA) MM_0505 MM_1070(mtaA) MM_1932(mtbA)
MMAZ: 
MVC: 
MEK: 
MLS: 
METM: 
MEF: 
MEQ: 
MSJ: 
MSZ: 
MSW: 
MTHE: 
MTHR: 
MHOR: 
MBU: 
MMET: 
MMH: 
MEV: 
MZH: 
MPY: 
MHZ: 
MST: 
Msp_0112(mtaA2) Msp_0182(mtaA4) Msp_0761(mtaA1) Msp_0774(mtaA3)
MSI: 
MEL: 
MEW: 
FPL: 
TAR: 
MAX: 
MER: 
MEAR: 
MARC: 
 » show all
Taxonomy
Reference
1  [PMID:8702528]
  Authors
LeClerc GM, Grahame DA
  Title
Methylcobamide:coenzyme M methyltransferase isozymes from Methanosarcina barkeri. Physicochemical characterization, cloning, sequence analysis, and heterologous gene expression.
  Journal
J. Biol. Chem. 271 (1996) 18725-31.
Reference
2  [PMID:8654414]
  Authors
Harms U, Thauer RK
  Title
Methylcobalamin: coenzyme M methyltransferase isoenzymes MtaA and MtbA from Methanosarcina barkeri. Cloning, sequencing and differential transcription of the encoding genes, and functional overexpression of the mtaA gene in Escherichia coli.
  Journal
Eur. J. Biochem. 235 (1996) 653-9.
  Sequence
Reference
3  [PMID:9363780]
  Authors
Sauer K, Thauer RK
  Title
Methanol:coenzyme M methyltransferase from Methanosarcina barkeri. Zinc dependence and thermodynamics of the methanol:cob(I)alamin methyltransferase reaction.
  Journal
Eur. J. Biochem. 249 (1997) 280-5.
Reference
4  [PMID:9057830]
  Authors
Sauer K, Harms U, Thauer RK
  Title
Methanol:coenzyme M methyltransferase from Methanosarcina barkeri. Purification,  properties and encoding genes of the corrinoid protein MT1.
  Journal
Eur. J. Biochem. 243 (1997) 670-7.
Reference
5  [PMID:10215883]
  Authors
Sauer K, Thauer RK.
  Title
Methanol:coenzyme M methyltransferase from Methanosarcina barkeri -- substitution of the corrinoid harbouring subunit MtaC by free cob(I)alamin.
  Journal
Eur. J. Biochem. 261 (1999) 674-81.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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