KEGG   ENZYME: 2.1.1.247Help
Entry
EC 2.1.1.247                Enzyme                                 
Name
[methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase;
methyltransferase 2 (ambiguous);
MT2 (ambiguous);
MT2-A;
mtbA (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
methylated monomethylamine-specific corrinoid protein:coenzyme M methyltransferase
Reaction(IUBMB)
a [methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M = methyl-CoM + a [Co(I) methylamine-specific corrinoid protein] [RN:R10000]
Reaction(KEGG)
Substrate
[methyl-Co(III) methylamine-specific corrinoid protein];
coenzyme M [CPD:C19637]
Product
methyl CoM [CPD:C03920];
[Co(I) methylamine-specific corrinoid protein]
Comment
Contains zinc [2]. The enzyme, which is involved in methanogenesis from mono-, di-, and trimethylamine, catalyses the transfer of a methyl group bound to the cobalt cofactor of several corrinoid proteins (mono-, di-, and trimethylamine-specific corrinoid proteins, cf. EC 2.1.1.248, methylamine---corrinoid protein Co-methyltransferase, EC 2.1.1.249, dimethylamine---corrinoid protein Co-methyltransferase, and EC 2.1.1.250, trimethylamine---corrinoid protein Co-methyltransferase) to coenzyme M, forming the substrate for EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase, the enzyme that catalyses the final step in methanogenesis.
Pathway
Methane metabolism
Microbial metabolism in diverse environments
Orthology
K14082  
[methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase
Genes
GEO: 
DTI: 
CTH: 
CTX: 
CBO: 
CBO1495(mtbA)
CBA: 
CBH: 
CBY: 
CBL: 
CBB: 
CBI: 
CLJ_B1598
CBF: 
CLI_1578
CBM: 
CBF_1558
CLJ: 
CLJU_c21060
CCB: 
Clocel_1249
CCL: 
Clocl_2729
CST: 
CLOST_0080
SWO: 
Swol_0419
DSY: 
DSY0986
DHD: 
Dhaf_2069
DKU: 
Desku_0050
TJR: 
TherJR_0979
SGY: 
Sgly_2537
DOR: 
Desor_1559
MTA: 
Moth_2346
TOC: 
Toce_0707
SRI: 
SELR_27640 SELR_27690(mtbA)
SHI: 
Shel_26140
TAZ: 
TREAZ_1477
TPI: 
TREPR_0753
MMP: 
MMP0831(mtbA)
MMQ: 
MmarC5_0838
MMX: 
MmarC6_1825
MMZ: 
MmarC7_0077
MMD: 
GYY_04820
MVO: 
Mvol_1577
MAC: 
MA0146(mtbA) MA0847(mtbA)
MBA: 
Mbar_A0841
MMA: 
MM_1439(mtbA) MM_1932(mtbA)
MBU: 
Mbur_0957 Mbur_2082
MMH: 
Mmah_0279
MEV: 
Metev_0310
MZH: 
Mzhil_1020
MST: 
Msp_0182(mtaA4)
FPL: 
Ferp_1761
 » show all
Taxonomy
Reference
1  [PMID:7635826]
  Authors
Burke SA, Krzycki JA
  Title
Involvement of the "A" isozyme of methyltransferase II and the 29-kilodalton corrinoid protein in methanogenesis from monomethylamine.
  Journal
J. Bacteriol. 177 (1995) 4410-6.
Reference
2  [PMID:8702528]
  Authors
LeClerc GM, Grahame DA
  Title
Methylcobamide:coenzyme M methyltransferase isozymes from Methanosarcina barkeri. Physicochemical characterization, cloning, sequence analysis, and heterologous gene expression.
  Journal
J. Biol. Chem. 271 (1996) 18725-31.
Reference
3  [PMID:9006042]
  Authors
Ferguson DJ Jr, Krzycki JA
  Title
Reconstitution of trimethylamine-dependent coenzyme M methylation with the trimethylamine corrinoid protein and the isozymes of methyltransferase II from Methanosarcina barkeri.
  Journal
J. Bacteriol. 179 (1997) 846-52.
Reference
4  [PMID:9642198]
  Authors
Burke SA, Lo SL, Krzycki JA
  Title
Clustered genes encoding the methyltransferases of methanogenesis from monomethylamine.
  Journal
J. Bacteriol. 180 (1998) 3432-40.
Reference
5  [PMID:10852929]
  Authors
Ferguson DJ Jr, Gorlatova N, Grahame DA, Krzycki JA
  Title
Reconstitution of dimethylamine:coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri.
  Journal
J. Biol. Chem. 275 (2000) 29053-60.
Other DBs
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IUBMB Enzyme Nomenclature: 
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BRENDA, the Enzyme Database: 
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