KEGG   ENZYME: 2.1.1.248Help
Entry
EC 2.1.1.248                Enzyme                                 

Name
methylamine---corrinoid protein Co-methyltransferase;
mtmB (gene name);
monomethylamine methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
monomethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase
Reaction(IUBMB)
methylamine + a [Co(I) methylamine-specific corrinoid protein] = a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia [RN:R10014]
Reaction(KEGG)
R10014;
(other) R09998
Show
Substrate
methylamine [CPD:C00218];
[Co(I) methylamine-specific corrinoid protein]
Product
[methyl-Co(III) methylamine-specific corrinoid protein];
ammonia [CPD:C00014]
Comment
The enzyme, which catalyses the transfer of a methyl group from methylamine to a methylamine-specific corrinoid protein (MtmC), is involved in methanogenesis from methylamine. The enzyme contains the unusual amino acid pyrrolysine [3]. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. The methylated corrinoid protein is substrate for EC 2.1.1.247, methylated methylamine-specific corrinoid protein:coenzyme M methyltransferase.
History
EC 2.1.1.248 created 2012
Pathway
Methane metabolism
Microbial metabolism in diverse environments
Orthology
K16176  
methylamine---corrinoid protein Co-methyltransferase
Genes
DAE: 
AAR: 
SRI: 
MAC: 
MA0144(mtmB1) MA2972(mtmB2)
MBA: 
MMA: 
MM_1436(mtmB) MM_1437(mtmB) MM_3335(mtmB)
MMAZ: 
MMH: 
MEV: 
MZH: 
MPY: 
MHZ: 
MAX: 
TAR: 
TPE: 
THB: 
 » show all
Taxonomy
Reference
1  [PMID:9195968]
  Authors
Burke SA, Krzycki JA
  Title
Reconstitution of Monomethylamine:Coenzyme M methyl transfer with a corrinoid protein and two methyltransferases purified from Methanosarcina barkeri.
  Journal
J. Biol. Chem. 272 (1997) 16570-7.
  Sequence
Reference
2  [PMID:9642198]
  Authors
Burke SA, Lo SL, Krzycki JA
  Title
Clustered genes encoding the methyltransferases of methanogenesis from monomethylamine.
  Journal
J. Bacteriol. 180 (1998) 3432-40.
  Sequence
Reference
3  [PMID:15450490]
  Authors
Krzycki JA
  Title
Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases.
  Journal
Curr. Opin. Chem. Biol. 8 (2004) 484-91.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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