KEGG   ENZYME: 2.1.1.250Help
Entry
EC 2.1.1.250                Enzyme                                 

Name
trimethylamine---corrinoid protein Co-methyltransferase;
mttB (gene name);
trimethylamine methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
trimethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase
Reaction(IUBMB)
trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein] = a [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine [RN:R10016]
Reaction(KEGG)
R10016;
(other) R09124
Show
Substrate
trimethylamine [CPD:C00565];
[Co(I) trimethylamine-specific corrinoid protein]
Product
[methyl-Co(III) trimethylamine-specific corrinoid protein];
dimethylamine [CPD:C00543]
Comment
The enzyme, which catalyses the transfer of a methyl group from trimethylamine to a trimethylamine-specific corrinoid protein (MttC), is involved in methanogenesis from trimethylamine. The enzyme contains the unusual amino acid pyrrolysine [2]. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. The methylated corrinoid protein is substrate for EC 2.1.1.247, methylated methylamine-specific corrinoid protein:coenzyme M methyltransferase.
History
EC 2.1.1.250 created 2012
Pathway
Methane metabolism
Microbial metabolism in diverse environments
Orthology
K14083  
trimethylamine---corrinoid protein Co-methyltransferase
Genes
TSN: 
AZA: 
DAK: 
DOL: 
DAL: 
DAT: 
HRM2_00490(mttB1) HRM2_01250(mttB2) HRM2_07480(mttB3) HRM2_09120(mttB4) HRM2_15910(mttB5) HRM2_15930(mttB6) HRM2_44090(mttB7) HRM2_44130(mttB8) HRM2_44190(mttB9) HRM2_44210(mttB10) HRM2_45990(mttB711)
DTO: 
MLO: 
MCI: 
MOP: 
MAM: 
HOE: 
AAK: 
SME: 
SMK: 
SMQ: 
SMX: 
SMI: 
SMEG: 
SMEL: 
SMER: 
SMD: 
RHI: 
SFH: 
SFD: 
EAD: 
ARA: 
RTR: 
NGL: 
NGG: 
SHZ: 
SIL: 
SIT: 
RMB: 
RSP: 
RSH: 
RSQ: 
RSK: 
RCP: 
JAN: 
RDE: 
RLI: 
DSH: 
PGA: 
PGL: 
PGD: 
OAT: 
OAR: 
OTM: 
LMD: 
RED: 
PTP: 
MALG: 
CON: 
RSU: 
HAT: 
LAP: 
DAA: 
PGV: 
APB: 
CACE: 
DSY: 
DHD: 
DDH: 
TJR: 
DOR: 
DMI: 
ELM: 
AWO: 
Awo_c05430(mttB3) Awo_c05440(mttB4) Awo_c05470(mttB5) Awo_c07540(mttB10) Awo_c27930(mttB21) Awo_c27940(mttB22)
TPZ: 
MAS: 
AAR: 
CAP: 
VBL: 
MAC: 
MA_0528(mttB) MA_0932(mttB)
MBY: 
MBW: 
MBAR: 
MMA: 
MM_1688(mttB) MM_1689(mttB) MM_2048(mttB) MM_2049(mttB)
MMAZ: 
MVC: 
MEK: 
MLS: 
METM: 
MEF: 
MEQ: 
MSJ: 
MSZ: 
MSW: 
MTHE: 
MTHR: 
MHOR: 
MBU: 
MMET: 
MMH: 
MEV: 
MZH: 
MPY: 
Mpsy_1687(mttB) Mpsy_1688(mttB2)
MHZ: 
TAR: 
MAX: 
MER: 
MARC: 
TPE: 
THB: 
TCB: 
LOKI: 
 » show all
Taxonomy
Reference
1  [PMID:9006042]
  Authors
Ferguson DJ Jr, Krzycki JA
  Title
Reconstitution of trimethylamine-dependent coenzyme M methylation with the trimethylamine corrinoid protein and the isozymes of methyltransferase II from Methanosarcina barkeri.
  Journal
J. Bacteriol. 179 (1997) 846-52.
  Sequence
Reference
2  [PMID:15450490]
  Authors
Krzycki JA
  Title
Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases.
  Journal
Curr. Opin. Chem. Biol. 8 (2004) 484-91.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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