KEGG   ENZYME: 2.1.1.252Help
Entry
EC 2.1.1.252                Enzyme                                 

Name
tetramethylammonium---corrinoid protein Co-methyltransferase;
mtqB (gene name);
tetramethylammonium methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
tetramethylammonium:5-hydroxybenzimidazolylcobamide Co-methyltransferase
Reaction(IUBMB)
tetramethylammonium + a [Co(I) tetramethylammonium-specific corrinoid protein] = a [methyl-Co(III) tetramethylammonium-specific corrinoid protein] + trimethylamine [RN:R10017]
Reaction(KEGG)
Substrate
tetramethylammonium [CPD:C20292];
[Co(I) tetramethylammonium-specific corrinoid protein]
Product
[methyl-Co(III) tetramethylammonium-specific corrinoid protein];
trimethylamine [CPD:C00565]
Comment
The enzyme, which catalyses the transfer of a methyl group from tetramethylammonium to a tetramethylammonium-specific corrinoid protein (MtqC), is involved in methanogenesis from tetramethylammonium. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. The methylated corrinoid protein is substrate for EC 2.1.1.253, methylated tetramethylammonium-specific corrinoid protein:coenzyme M methyltransferase.
History
EC 2.1.1.252 created 2012
Reference
1  [PMID:9732435]
  Authors
Asakawa S, Sauer K, Liesack W, Thauer RK
  Title
Tetramethylammonium:coenzyme M methyltransferase system from methanococcoides sp
  Journal
Arch. Microbiol. 170 (1998) 220-6.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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