KEGG   ENZYME: 2.1.1.255Help
Entry
EC 2.1.1.255                Enzyme                                 

Name
geranyl diphosphate 2-C-methyltransferase;
SCO7701;
GPP methyltransferase;
GPPMT;
2-methyl-GPP synthase;
MGPPS;
geranyl pyrophosphate methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:geranyl-diphosphate 2-C-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + geranyl diphosphate = S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate [RN:R09940]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
geranyl diphosphate [CPD:C00341]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(E)-2-methylgeranyl diphosphate [CPD:C20235]
Comment
This enzyme, along with EC 4.2.3.118, 2-methylisoborneol synthase, produces 2-methylisoborneol, an odiferous compound produced by soil microorganisms with a strong earthy/musty odour.
History
EC 2.1.1.255 created 2012
Orthology
K16217  
geranyl diphosphate 2-C-methyltransferase
Genes
MMI: 
MLI: 
NBR: 
SCO: 
SCO7701(SCBAC12C8.02)
SMA: 
SGR: 
SCB: 
SVL: 
SFA: 
SBH: 
SVE: 
SDV: 
SCI: 
SRC: 
KSK: 
NDA: 
NAL: 
B005_4058(gdpmt)
SEN: 
AMD: 
AMN: 
AMM: 
AMZ: 
AOI: 
SESP: 
ASE: 
CAI: 
SNA: 
 » show all
Taxonomy
Reference
1  [PMID:18563898]
  Authors
Wang CM, Cane DE
  Title
Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor.
  Journal
J. Am. Chem. Soc. 130 (2008) 8908-9.
  Organism
Streptomyces coelicolor
  Sequence
[sco:SCO7701]
Reference
2  [PMID:21393856]
  Authors
Ariyawutthiphan O, Ose T, Tsuda M, Gao Y, Yao M, Minami A, Oikawa H, Tanaka I
  Title
Crystallization and preliminary X-ray crystallographic study of a methyltransferase involved in 2-methylisoborneol biosynthesis in Streptomyces lasaliensis.
  Journal
Acta. Crystallogr. Sect. F. Struct. Biol. Cryst. Commun. 67 (2011) 417-20.
Reference
3  [PMID:18492804]
  Authors
Komatsu M, Tsuda M, Omura S, Oikawa H, Ikeda H
  Title
Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 7422-7.
  Organism
Saccharopolyspora erythraea, Streptomyces ambofaciens, Streptomyces lasaliensis
  Sequence
Reference
4  [PMID:21174459]
  Authors
Giglio S, Chou WK, Ikeda H, Cane DE, Monis PT
  Title
Biosynthesis of 2-methylisoborneol in cyanobacteria.
  Journal
Environ. Sci. Technol. 45 (2011) 992-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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