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Entry
EC 2.1.1.256                Enzyme                                 

Name
tRNA (guanine6-N2)-methyltransferase;
methyltransferase Trm14;
m2G6 methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:tRNA (guanine6-N2)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + guanine6 in tRNA = S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNA
Substrate
S-adenosyl-L-methionine [CPD:C00019];
guanine6 in tRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N2-methylguanine6 in tRNA
Comment
The enzyme specifically methylates guanine6 at N2 in tRNA.
History
EC 2.1.1.256 created 2012
Orthology
K16318  
tRNA (guanine6-N2)-methyltransferase
Genes
HAO: 
STA: 
FLI: 
TTK: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MFV: 
MKA: 
AFU: 
AFG: 
APO: 
FPL: 
GAH: 
NPH: 
NP_0864A(trm14)
NMO: 
Nmlp_3856(trm14)
PHO: 
PH0644(PH0644)
PAB: 
PFU: 
PFI: 
PYN: 
PYA: 
PYS: 
TKO: 
TON: 
TGA: 
TSI: 
TBA: 
THE: 
THA: 
THM: 
TLT: 
THS: 
TNU: 
TEU: 
TGY: 
THV: 
PPAC: 
ABI: 
ACF: 
APE: 
ACJ: 
SMR: 
SHC: 
IHO: 
IIS: 
IAG: 
HBU: 
PFM: 
PDL: 
PAI: 
PIS: 
PCL: 
PAS: 
PYR: 
POG: 
TNE: 
PYW: 
TUZ: 
TTN: 
VDI: 
VMO: 
THB: 
TCB: 
CSU: 
NEQ: 
KCR: 
BARC: 
 » show all
Taxonomy
Reference
1  [PMID:21693558]
  Authors
Menezes S, Gaston KW, Krivos KL, Apolinario EE, Reich NO, Sowers KR, Limbach PA, Perona JJ
  Title
Formation of m2G6 in Methanocaldococcus jannaschii tRNA catalyzed by the novel methyltransferase Trm14.
  Journal
Nucleic. Acids. Res. 39 (2011) 7641-55.
  Sequence
[mja:MJ_0438]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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