KEGG   ENZYME: 2.1.1.268Help
Entry
EC 2.1.1.268                Enzyme                                 

Name
tRNAThr (cytosine32-N3)-methyltransferase;
ABP140;
Trm140p
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:tRNAThr (cytosine32-N3)-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + cytosine32 in tRNAThr = S-adenosyl-L-homocysteine + N3-methylcytosine32 in tRNAThr;
(2) S-adenosyl-L-methionine + cytosine32 in tRNASer = S-adenosyl-L-homocysteine + N3-methylcytosine32 in tRNASer
Substrate
S-adenosyl-L-methionine [CPD:C00019];
cytosine32 in tRNAThr;
cytosine32 in tRNASer
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N3-methylcytosine32 in tRNAThr;
N3-methylcytosine32 in tRNASer
Comment
The enzyme from Saccharomyces cerevisiae specifically methylates cytosine32 in tRNAThr and in tRNASer.
History
EC 2.1.1.268 created 2013
Orthology
K17053  
tRNAThr (cytosine32-N3)-methyltransferase
Genes
SCE: 
YOR239W(ABP140)
AGO: 
KLA: 
CGR: 
NDI: 
NDAI_0E01210(NDAI0E01210)
TPF: 
TPHA_0D01190(TPHA0D01190)
TBL: 
TBLA_0B03890(TBLA0B03890) TBLA_0C01800(TBLA0C01800)
TDL: 
TDEL_0A06110(TDEL0A06110)
KAF: 
KAFR_0A03810(KAFR0A03810)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CaO19.11160(ABP140) CaO19.3676(ABP140)
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
NTE: 
NEUTE1DRAFT77456(NEUTE1DRAFT_77456)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
VDA: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_1974194(AO090012000934)
ANG: 
ANI_1_1326124(An14g03270)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
PBN: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
DSQ: 
PCO: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT69948(AGABI1DRAFT_69948)
ABV: 
AGABI2DRAFT205628(AGABI2DRAFT_205628)
CPUT: 
SLA: 
WSE: 
WIC: 
UMA: 
PFP: 
MGL: 
PGR: 
MLR: 
 » show all
Taxonomy
Reference
1  [PMID:21518805]
  Authors
Noma A, Yi S, Katoh T, Takai Y, Suzuki T, Suzuki T
  Title
Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae.
  Journal
RNA. 17 (2011) 1111-9.
  Sequence
[sce:YOR239W]
Reference
2  [PMID:21518804]
  Authors
D'Silva S, Haider SJ, Phizicky EM
  Title
A domain of the actin binding protein Abp140 is the yeast methyltransferase responsible for 3-methylcytidine modification in the tRNA anti-codon loop.
  Journal
RNA. 17 (2011) 1100-10.
  Sequence
[sce:YOR239W]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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