KEGG   ENZYME: 2.1.1.268Help
Entry
EC 2.1.1.268                Enzyme                                 

Name
tRNAThr (cytosine32-N3)-methyltransferase;
ABP140;
Trm140p
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:tRNAThr (cytosine32-N3)-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + cytosine32 in tRNAThr = S-adenosyl-L-homocysteine + N3-methylcytosine32 in tRNAThr;
(2) S-adenosyl-L-methionine + cytosine32 in tRNASer = S-adenosyl-L-homocysteine + N3-methylcytosine32 in tRNASer
Substrate
S-adenosyl-L-methionine [CPD:C00019];
cytosine32 in tRNAThr;
cytosine32 in tRNASer
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N3-methylcytosine32 in tRNAThr;
N3-methylcytosine32 in tRNASer
Comment
The enzyme from Saccharomyces cerevisiae specifically methylates cytosine32 in tRNAThr and in tRNASer.
History
EC 2.1.1.268 created 2013
Orthology
K17053  tRNAThr (cytosine32-N3)-methyltransferase
Genes
SCE: YOR239W(ABP140)
AGO: AGOS_ACR130W
KLA: KLLA0F11385g
KMX: KLMA_20196(ABP140)
CGR: CAGL0J03780g
NDI: NDAI_0E01210(NDAI0E01210)
TPF: TPHA_0D01190(TPHA0D01190)
TBL: TBLA_0B03890(TBLA0B03890) TBLA_0C01800(TBLA0C01800)
TDL: TDEL_0A06110(TDEL0A06110)
KAF: KAFR_0A03810(KAFR0A03810)
CAL: CAALFM_C102190WA(ABP140)
CAUR: QG37_02930
SLB: AWJ20_210(ABP140)
NCR: NCU04647
NTE: NEUTE1DRAFT77456(NEUTE1DRAFT_77456)
MGR: MGG_13398
MAW: MAC_02427
MAJ: MAA_06813
CMT: CCM_03905
MBE: MBM_07827
ANI: AN2190.2
ANG: ANI_1_1326124(An14g03270)
ABE: ARB_01396
TVE: TRV_02216
PTE: PTT_08189
CNE: CNJ02050
CNB: CNBJ1410
ABP: AGABI1DRAFT69948(AGABI1DRAFT_69948)
ABV: AGABI2DRAFT205628(AGABI2DRAFT_205628)
MGL: MGL_3396
 » show all
Taxonomy
Reference
1  [PMID:21518805]
  Authors
Noma A, Yi S, Katoh T, Takai Y, Suzuki T, Suzuki T
  Title
Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae.
  Journal
RNA. 17 (2011) 1111-9.
  Sequence
[sce:YOR239W]
Reference
2  [PMID:21518804]
  Authors
D'Silva S, Haider SJ, Phizicky EM
  Title
A domain of the actin binding protein Abp140 is the yeast methyltransferase responsible for 3-methylcytidine modification in the tRNA anti-codon loop.
  Journal
RNA. 17 (2011) 1100-10.
  Sequence
[sce:YOR239W]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.268
IUBMB Enzyme Nomenclature: 2.1.1.268
ExPASy - ENZYME nomenclature database: 2.1.1.268
BRENDA, the Enzyme Database: 2.1.1.268

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