KEGG   ENZYME: 2.1.1.269Help
Entry
EC 2.1.1.269                Enzyme                                 

Name
dimethylsulfoniopropionate demethylase;
dmdA (gene name);
dimethylsulfoniopropionate-dependent demethylase A
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S,S-dimethyl-beta-propiothetin:tetrahydrofolate S-methyltransferase
Reaction(IUBMB)
S,S-dimethyl-beta-propiothetin + tetrahydrofolate = 3-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate [RN:R10333]
Reaction(KEGG)
Substrate
S,S-dimethyl-beta-propiothetin [CPD:C04022];
tetrahydrofolate [CPD:C00101]
Product
3-(methylsulfanyl)propanoate [CPD:C08276];
5-methyltetrahydrofolate [CPD:C00440]
Comment
The enzyme from the marine bacteria Pelagibacter ubique and Ruegeria pomeroyi are specific towards S,S-dimethyl-beta-propiothetin. They do not demethylate glycine-betaine [1,2].
History
EC 2.1.1.269 created 2013
Pathway
ec00920  Sulfur metabolism
Orthology
K17486  dimethylsulfoniopropionate demethylase
Genes
GAI: IMCC3135_15030(dmdA)
HOE: IMCC20628_01219
SIL: SPO1913(dmdA)
SIT: TM1040_1444
RMB: K529_006360(dmdA)
JAN: Jann_2379
RDE: RD1_2288
RLI: RLO149_c022350
DSH: Dshi_2320(gcvT1)
PGA: PGA1_262p01830
OTM: OSB_12930(dmdA)
LMD: METH_10405(dmdA)
MALG: MALG_05026
LABR: CHH27_18755(dmdA)
TOM: BWR18_06790(dmdA)
RMM: ROSMUCSMR3_03150(dmdA)
 » show all
Taxonomy
Reference
1  [PMID:9396840]
  Authors
Jansen M, Hansen TA
  Title
Tetrahydrofolate serves as a methyl acceptor in the demethylation of dimethylsulfoniopropionate in cell extracts of sulfate-reducing bacteria.
  Journal
Arch. Microbiol. 169 (1998) 84-7.
Reference
2  [PMID:18849431]
  Authors
Reisch CR, Moran MA, Whitman WB
  Title
Dimethylsulfoniopropionate-dependent demethylase (DmdA) from Pelagibacter ubique  and Silicibacter pomeroyi.
  Journal
J. Bacteriol. 190 (2008) 8018-24.
  Sequence
[pub:SAR11_0246] [sil:SPO1913]
Reference
3  [PMID:22162093]
  Authors
Schuller DJ, Reisch CR, Moran MA, Whitman WB, Lanzilotta WN
  Title
Structures of dimethylsulfoniopropionate-dependent demethylase from the marine organism Pelagabacter ubique.
  Journal
Protein. Sci. 21 (2012) 289-98.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.269
IUBMB Enzyme Nomenclature: 2.1.1.269
ExPASy - ENZYME nomenclature database: 2.1.1.269
BRENDA, the Enzyme Database: 2.1.1.269

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