KEGG   ENZYME: 2.1.1.272Help
Entry
EC 2.1.1.272                Enzyme                                 

Name
cobalt-factor III methyltransferase;
CbiH60 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:cobalt-factor III 17-methyltransferase (ring contracting)
Reaction(IUBMB)
S-adenosyl-L-methionine + cobalt-factor III + reduced acceptor = S-adenosyl-L-homocysteine + cobalt-precorrin-4 + acceptor
Substrate
S-adenosyl-L-methionine [CPD:C00019];
cobalt-factor III [CPD:C17401];
reduced acceptor [CPD:C00030]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
cobalt-precorrin-4;
acceptor [CPD:C00028]
Comment
Isolated from Bacillus megaterium. The enzyme catalyses both methylation at C-17 and ring contraction. Contains a [4Fe-4S] cluster. It can also convert cobalt-precorrin-3 to cobalt-precorrin-4. The reductant may be thioredoxin.
History
EC 2.1.1.272 created 2013
Reference
1  [PMID:23155054]
  Authors
Moore SJ, Biedendieck R, Lawrence AD, Deery E, Howard MJ, Rigby SE, Warren MJ
  Title
Characterization of the enzyme CbiH60 involved in anaerobic ring contraction of the cobalamin (vitamin B12) biosynthetic pathway.
  Journal
J. Biol. Chem. 288 (2013) 297-305.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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