KEGG   ENZYME: 2.1.1.280Help
Entry
EC 2.1.1.280                Enzyme                                 

Name
selenocysteine Se-methyltransferase;
SMT
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-methyl-L-methionine:L-selenocysteine Se-methyltransferase
Reaction(IUBMB)
S-methyl-L-methionine + L-selenocysteine = L-methionine + Se-methyl-L-selenocysteine [RN:R10430]
Reaction(KEGG)
Substrate
S-methyl-L-methionine [CPD:C03172];
L-selenocysteine [CPD:C05688]
Product
L-methionine [CPD:C00073];
Se-methyl-L-selenocysteine [CPD:C05689]
Comment
The enzyme uses S-adenosyl-L-methionine as methyl donor less actively than S-methyl-L-methionine. The enzyme from broccoli (Brassica oleracea var. italica) also has the activity of EC 2.1.1.10, homocysteine S-methyltransferase [4].
History
EC 2.1.1.280 created 2013
Reference
1  [PMID:8706715]
  Authors
Neuhierl B, Bock A
  Title
On the mechanism of selenium tolerance in selenium-accumulating plants. Purification and characterization of a specific selenocysteine methyltransferase  from cultured cells of Astragalus bisculatus.
  Journal
Eur. J. Biochem. 239 (1996) 235-8.
  Sequence
Reference
2  [PMID:10026151]
  Authors
Neuhierl B, Thanbichler M, Lottspeich F, Bock A
  Title
A family of S-methylmethionine-dependent thiol/selenol methyltransferases. Role in selenium tolerance and evolutionary relation.
  Journal
J. Biol. Chem. 274 (1999) 5407-14.
  Sequence
Reference
3  [PMID:15863700]
  Authors
Lyi SM, Heller LI, Rutzke M, Welch RM, Kochian LV, Li L
  Title
Molecular and biochemical characterization of the selenocysteine Se-methyltransferase gene and Se-methylselenocysteine synthesis in broccoli.
  Journal
Plant. Physiol. 138 (2005) 409-20.
  Sequence
Reference
4  [PMID:17391716]
  Authors
Lyi SM, Zhou X, Kochian LV, Li L
  Title
Biochemical and molecular characterization of the homocysteine S-methyltransferase from broccoli (Brassica oleracea var. italica).
  Journal
Phytochemistry. 68 (2007) 1112-9.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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