KEGG   ENZYME: 2.1.1.281Help
Entry
EC 2.1.1.281                Enzyme                                 

Name
phenylpyruvate C3-methyltransferase;
phenylpyruvate Cbeta-methyltransferase;
phenylpyruvate methyltransferase;
mppJ (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:2-oxo-3-phenylpropanoate C3-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 3-phenylpyruvate = S-adenosyl-L-homocysteine + (3S)-2-oxo-3-phenylbutanoate [RN:R10431]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
3-phenylpyruvate
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(3S)-2-oxo-3-phenylbutanoate [CPD:C20646]
Comment
The enzyme from the bacterium Streptomyces hygroscopicus NRRL3085 is involved in synthesis of the nonproteinogenic amino acid (2S,3S)-beta-methyl-phenylalanine, a building block of the antibiotic mannopeptimycin.
History
EC 2.1.1.281 created 2013
Reference
1  [PMID:19731276]
  Authors
Huang YT, Lyu SY, Chuang PH, Hsu NS, Li YS, Chan HC, Huang CJ, Liu YC, Wu CJ, Yang WB, Li TL
  Title
In vitro characterization of enzymes involved in the synthesis of nonproteinogenic residue (2S,3S)-beta-methylphenylalanine in glycopeptide antibiotic mannopeptimycin.
  Journal
Chembiochem. 10 (2009) 2480-7.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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