KEGG   ENZYME: 2.1.1.284Help
Entry
EC 2.1.1.284                Enzyme                                 

Name
8-demethylnovobiocic acid C8-methyltransferase;
NovO
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:8-demethylnovobiocic acid C8-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 8-demethylnovobiocic acid = S-adenosyl-L-homocysteine + novobiocic acid [RN:R10454]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
8-demethylnovobiocic acid [CPD:C20629]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
novobiocic acid [CPD:C12474]
Comment
The enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin.
History
EC 2.1.1.284 created 2013
Pathway
Novobiocin biosynthesis
Biosynthesis of antibiotics
Orthology
K12705  
8-demethylnovobiocic acid C8-methyltransferase
Reference
1  [PMID:16274243]
  Authors
Pacholec M, Tao J, Walsh CT
  Title
CouO and NovO: C-methyltransferases for tailoring the aminocoumarin scaffold in coumermycin and novobiocin antibiotic biosynthesis.
  Journal
Biochemistry. 44 (2005) 14969-76.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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