KEGG   ENZYME: 2.1.1.286Help
Entry
EC 2.1.1.286                Enzyme                                 

Name
25S rRNA (adenine2142-N1)-methyltransferase;
BMT2 (gene name);
25S rRNA m1A2142 methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:25S rRNA (adenine2142-N1)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + adenine2142 in 25S rRNA = S-adenosyl-L-homocysteine + N1-methyladenine2142 in 25S rRNA [RN:R10497]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
adenine2142 in 25S rRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N1-methyladenine2142 in 25S rRNA
Comment
In the yeast Saccharomyces cerevisiae this methylation is important for resistance towards hydrogen peroxide and the antibiotic anisomycin.
History
EC 2.1.1.286 created 2013
Orthology
K18849  
25S rRNA (adenine2142-N1)-methyltransferase
Genes
BFO: 
SPU: 
SKO: 
NVE: 
ADF: 
TAD: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CCP: 
SCE: 
YBR141C(BMT2)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0I02310(NCAS0I02310)
NDI: 
NDAI_0A06890(NDAI0A06890)
TPF: 
TPHA_0M00760(TPHA0M00760)
TBL: 
TBLA_0E03410(TBLA0E03410)
TDL: 
TDEL_0D05000(TDEL0D05000)
KAF: 
KAFR_0G01450(KAFR0G01450)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
NTE: 
NEUTE1DRAFT81366(NEUTE1DRAFT_81366)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
NHE: 
TRE: 
CMT: 
VDA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_1178184(AO090009000697)
ANG: 
ANI_1_320154(An17g02230)
AFV: 
ACT: 
PCS: 
CIM: 
CPW: 
PBL: 
PBN: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
DSQ: 
PCO: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT118273(AGABI1DRAFT_118273)
ABV: 
AGABI2DRAFT199801(AGABI2DRAFT_199801)
CPUT: 
SLA: 
WSE: 
WIC: 
UMA: 
PFP: 
PGR: 
MLR: 
MBR: 
ACAN: 
PTI: 
NGD: 
PIF: 
PSOJ: 
SPAR: 
EHX: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:23558746]
  Authors
Sharma S, Watzinger P, Kotter P, Entian KD
  Title
Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in Saccharomyces cerevisiae.
  Journal
Nucleic. Acids. Res. 41 (2013) 5428-43.
  Sequence
[sce:YBR141C]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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