KEGG   ENZYME: 2.1.1.291Help
Entry
EC 2.1.1.291                Enzyme                                 

Name
(R,S)-reticuline 7-O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:(R,S)-reticuline 7-O-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + (S)-reticuline = S-adenosyl-L-homocysteine + (S)-laudanine [RN:R10605];
(2) S-adenosyl-L-methionine + (R)-reticuline = S-adenosyl-L-homocysteine + (R)-laudanine [RN:R10606]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
(S)-reticuline [CPD:C02105];
(R)-reticuline [CPD:C05178]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(S)-laudanine [CPD:C20712];
(R)-laudanine [CPD:C09555]
Comment
The enzyme from the plant Papaver somniferum (opium poppy) methylates (S)- and (R)-reticuline with equal efficiency and is involved in the biosynthesis of tetrahydrobenzylisoquinoline alkaloids.
History
EC 2.1.1.291 created 2013
Pathway
Isoquinoline alkaloid biosynthesis
Orthology
K13390  
(R,S)-reticuline 7-O-methyltransferase
Reference
1  [PMID:14675446]
  Authors
Ounaroon A, Decker G, Schmidt J, Lottspeich F, Kutchan TM.
  Title
(R,S)-Reticuline 7-O-methyltransferase and (R,S)-norcoclaurine 6-O-methyltransferase of Papaver somniferum - cDNA cloning and characterization of methyl transfer enzymes of alkaloid biosynthesis in opium poppy.
  Journal
Plant. J. 36 (2003) 808-19.
  Sequence
Reference
2  [PMID:15353584]
  Authors
Weid M, Ziegler J, Kutchan TM
  Title
The roles of latex and the vascular bundle in morphine biosynthesis in the opium  poppy, Papaver somniferum.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 13957-62.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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