KEGG   ENZYME: 2.1.1.293Help
Entry
EC 2.1.1.293                Enzyme                                 

Name
6-hydroxytryprostatin B O-methyltransferase;
ftmD (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:6-hydroxytryprostatin B O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 6-hydroxytryprostatin B = S-adenosyl-L-homocysteine + tryprostatin A [RN:R10588]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
6-hydroxytryprostatin B [CPD:C20513]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
tryprostatin A [CPD:C20607]
Comment
Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, fumitremorgins and verruculogen.
History
EC 2.1.1.293 created 2013
Pathway
Staurosporine biosynthesis
Biosynthesis of antibiotics
Orthology
K18280  
6-hydroxytryprostatin B O-methyltransferase
Genes
NHE: 
AFM: 
AOR: 
AOR_1_72024(AO090010000047)
ANG: 
ANI_1_2036014(An01g15010)
AFV: 
NFI: 
ABE: 
TVE: 
PTE: 
Taxonomy
Reference
1  [PMID:23649274]
  Authors
Kato N, Suzuki H, Okumura H, Takahashi S, Osada H
  Title
A point mutation in ftmD blocks the fumitremorgin biosynthetic pathway in Aspergillus fumigatus strain Af293.
  Journal
Biosci. Biotechnol. Biochem. 77 (2013) 1061-7.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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